Antifungal immunity in patients with chronic rhinosinusitis with nasal polyps

Pestova R.M.; Aznabaeva L.F.; Savelieva E.E.; Samorodov A.V.

doi:https://doi.org/10.17116/otorino20248906140

Pestova R.M.

Bashkir State Medical University

ORCID: 0000-0001-5402-273X

Aznabaeva L.F.

Bashkir State Medical University;
Kuvatov Republican Clinical Hospital

ORCID: 0000-0002-8764-2334

Savelieva E.E.

Bashkir State Medical University

ORCID: 0000-0002-2009-8469

Samorodov A.V.

Bashkir State Medical University

ORCID: 0000-0001-9302-499X

Antifungal immunity in patients with chronic rhinosinusitis with nasal polyps

Authors:

Pestova R.M., Aznabaeva L.F., Savelieva E.E., Samorodov A.V.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2024;89(6): 40‑45

DOI: 10.17116/otorino20248906140

Read: 1368 times

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To cite this article:

Pestova RM, Aznabaeva LF, Savelieva EE, Samorodov AV. Antifungal immunity in patients with chronic rhinosinusitis with nasal polyps. Russian Bulletin of Otorhinolaryngology. 2024;89(6):40‑45. (In Russ.)
https://doi.org/10.17116/otorino20248906140

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

OBJECTIVE

To evaluate the characteristics of antifungal immunity in patients with bilateral chronic rhinosinusitis with nasal polyps.

MATERIAL AND METHODS

The study included 74 patients with bilateral chronic rhinosinusitis with nasal polyps and a control group consisting of 30 almost healthy individuals. All patients underwent surgery and were divided into two groups: Group I — with liquid secretion (n=39), Group II — with thick secretion in the paranasal sinuses (n=35). All participants underwent mycological examination, levels of specific antifungal antibodies IgG and IgE in the serum were assessed by ELISA, and rhinocytograms of the middle nasal meatus were analyzed.

RESULTS

The results demonstrated that fungal growth in the swabs was detected in all groups within acceptable limits (<10⁵ CFU/mL). The incidence was comparable between groups. The spectrum of fungal flora differed significantly: Candida species predominated in the control group and among patients with thick mucin, while the Aspergillus genus was more prevalent among patients with liquid mucin (p<0.05). In carriers of Candida fungi in the group of patients with thick mucin, the concentration of specific antibodies was higher — IgE (p<0.05) and IgG (p>0.05). Carriage of Aspergillus species was not accompanied by the development of an antibody-mediated immune response. According to the rhinocytogram data, all patients with polypoid rhinosinusitis exhibited reduced neutrophil content. In the group with thick mucin, low neutrophil content was accompanied by eosinophilia in the mucosal lining (p<0.05).

CONCLUSION

The study of antifungal immunity in patients with chronic rhinosinusitis with nasal polyps revealed the formation of an immune response predominantly to Candida species, which was more pronounced in patients with thick mucus. Specific immunoglobulins of classes G and E were formed even in individuals with low fungal colonization and were accompanied by eosinophilia in the nasal mucosa. Aspergillus carriage was not accompanied by activation of a specific antibody response.

Keywords:

chronic rhinosinusitis with nasal polyps

immunity

mucin

fungi

inflammation

Authors:

Pestova R.M.

Bashkir State Medical University

ORCID: 0000-0001-5402-273X

Aznabaeva L.F.

Bashkir State Medical University;
Kuvatov Republican Clinical Hospital

ORCID: 0000-0002-8764-2334

Savelieva E.E.

Bashkir State Medical University

ORCID: 0000-0002-2009-8469

Samorodov A.V.

Bashkir State Medical University

ORCID: 0000-0001-9302-499X

Received:

15.05.2024

Accepted:

13.08.2024

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References:

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