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Khadorych M.A.

National Medical Research Center for Therapy and Preventive Medicine

Gumanova N.G.

National Medical Research Center for Therapy and Preventive Medicine

Vasilyev D.K.

National Medical Research Center for Therapy and Preventive Medicine

Glutathione-S-transferase in the context of antioxidant protection against cardiovascular diseases

Authors:

Khadorych M.A., Gumanova N.G., Vasilyev D.K.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(12): 124‑129

DOI: 10.17116/profmed202528121124

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Table of contents

GLUTATHIONE-S-TRANSFERASE IN THE CONTEXT OF ANTIOXIDANT PROTECTION AGAINST CARDIOVASCULAR DISEASES
GLUTATHIONE-S-TRANSFERASE IN THE CONTEXT OF ANTIOXIDANT PROTECTION AGAINST CARDIOVASCULAR DISEASES

To cite this article:

Khadorych MA, Gumanova NG, Vasilyev DK. Glutathione-S-transferase in the context of antioxidant protection against cardiovascular diseases. Russian Journal of Preventive Medicine. 2025;28(12):124‑129. (In Russ.)
https://doi.org/10.17116/profmed202528121124

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Cardiovascular diseases (CVDs) still impact mortality rates worldwide, despite significant advances in their diagnosis and treatment. Oxidative stress plays a crucial role in the pathogenesis and development of CVDs. The function of some antioxidant enzymes across biological species is well understood; however, the contribution of the glutathione S-transferase (GST) family to the pathogenesis of CVDs, which is an important link in detoxification and antioxidant protection, is not well studied. Understanding the role of GST in maintaining normal cardiovascular function may open new opportunities to develop more effective approaches to treating CVD.

OBJECTIVE

To summarize the available data on the role of glutathione S-transferases, in particular Mu class glutathione S-transferase, in the antioxidant protection of the human body, including in cardiovascular diseases associated with atherosclerosis, and identify promising areas for further research.

MATERIALS AND METHODS

The PubMed and eLibrary (Science Index) databases were searched using the following keywords: «atherosclerosis», «cardiovascular diseases», «glutathione S-transferase», «oxidative stress», and «antioxidant defense», with a 25-year search depth. In addition, the review includes individual archival publications of fundamental scientific significance.

RESULTS

In the development of cardiovascular diseases associated with atherosclerosis, several initial conditions are distinguished, including dyslipidemia, insulin resistance, endothelial dysfunction, and oxidative stress, a companion of acute and chronic inflammation. Virtually all of these conditions are associated with a weakening of the body’s antioxidant defenses. Since GSTs are key participants in the antioxidant system, the review considers the enzymatic and non-enzymatic antioxidant systems and the role of GST, in particular GSTmu, in atherosclerosis.

CONCLUSION

Glutathione S-transferases play an important role in protecting the body against cardiovascular disease by reducing oxidative stress and inflammation. Genetic variations in glutathione S-transferases can significantly affect the body’s predisposition to atherosclerosis. The development of methods to control the activity of these enzymes may represent a promising direction in the treatment and prevention of cardiovascular diseases.

Keywords:

glutathione S-transferase
GST
GSTmu
oxidative stress
antioxidant defense
cardiovascular diseases
atherosclerosis

Authors:

Khadorych M.A.

National Medical Research Center for Therapy and Preventive Medicine

Gumanova N.G.

National Medical Research Center for Therapy and Preventive Medicine

Vasilyev D.K.

National Medical Research Center for Therapy and Preventive Medicine

Received:

25.07.2025

Accepted:

13.10.2025

Close metadata

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