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Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Budnevsky A.V.

N.N. Burdenko Voronezh State Medical University

Ovsyannikov E.S.

N.N. Burdenko Voronezh State Medical University

Kontsevaya A.V.

National Medical Research Center for Therapy and Preventive Medicine

Drobysheva E.S.

N.N. Burdenko Voronezh State Medical University

Sarcopenic obesity: patterns and paradoxes

Authors:

Drapkina O.M., Budnevsky A.V., Ovsyannikov E.S., Kontsevaya A.V., Drobysheva E.S.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2021;24(1): 73‑78

DOI: 10.17116/profmed20212401173

Read: 7900 times

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Table of contents

SARCOPENIC OBESITY: PATTERNS AND PARADOXES
SARCOPENIC OBESITY: PATTERNS AND PARADOXES

To cite this article:

Drapkina OM, Budnevsky AV, Ovsyannikov ES, Kontsevaya AV, Drobysheva ES. Sarcopenic obesity: patterns and paradoxes. Russian Journal of Preventive Medicine. 2021;24(1):73‑78. (In Russ.)
https://doi.org/10.17116/profmed20212401173

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Sarcopenic obesity combines the signs of sarcopenia and obesity. It seems appropriate to differentiate the phenotypes of visceral and subcutaneous obesity in the context of sarcopenia. As the main methods of diagnosing sarcopenic obesity, most authors prefer dual-energy X-ray absorptiometry or bioelectrical impedance analysis with the determination of the percentage of fat mass and lean mass. The research results highlight the possible role of pro-inflammatory cytokines secreted by metabolically active adipocytes in the mechanism of development and progression of sarcopenic obesity, as well as imbalance of cytokines and myokines. The phenotype of visceral sarcopenic obesity is associated with inflammation, an unfavorable metabolic profile, while patients with excessive accumulation of subcutaneous fat have a lower mortality rate — the so-called “obesity paradox”. The review also provides data on the clinical consequences and associations of sarcopenic obesity with overall mortality, the outcome of cancer, cardiovascular diseases, and diabetes mellitus.

Keywords:

obesity
sarcopenia
obesity paradox
inflammation
adipocytes

Authors:

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Budnevsky A.V.

N.N. Burdenko Voronezh State Medical University

Ovsyannikov E.S.

N.N. Burdenko Voronezh State Medical University

Kontsevaya A.V.

National Medical Research Center for Therapy and Preventive Medicine

Drobysheva E.S.

N.N. Burdenko Voronezh State Medical University

Received:

23.03.2020

Accepted:

02.11.2020

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