In the XXth —XXIst centuries, the vast majority of deaths in Russia and worldwide have been caused by chronic noncommunicable diseases (CNCDs) that include cardiovascular disease (CVD), cancer, chronic bronchopulmonary diseases, and diabetes. CNCDs are responsible for over 75% of all deaths in Russia. The leading noncommunicable diseases (NCDs) in many countries are CVD and their events, which prevail in the structure of death causes. In the Russian Federation, CVD is the main cause of adult mortality. Increasing attention has been recently paid to male health because CVD morbidity and mortality rates are 3—5 times greater in men than in women. The International Society for the Study of the Aging Males (ISSAM) points out that the priority diseases in men aged over 50 years are CVD, cancer, benign prostatic hyperplasia (BPH), erectile dysfunction, and depression. They often develop at the same time and have similar clinical and social implications, requiring a unified multidisciplinary approach when choosing the strategy and tactics of their treatment. BPH is one of the most common diseases occurring in men aged 40—50 years and older. Recent studies indicate that there is a relationship between BPH and metabolic syndrome components. The high frequency of BPH in patients with vascular diseases proves that this condition is now a multidisciplinary problem that necessitates a comprehensive approach to both the prevention and treatment of this disease. Thus, when choosing a treatment option for a patient with CVD, particularly with hypertension and BPH, some possible interactions of drugs used in the treatment of both diseases should be kept in mind.