Immunological aspects of reccurent pregnancy loss

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Reccurent pregnancy loss remains an unsolved problem of modern medicine. This complication affects 2—5% of married couples and has serious physical and psychological consequences for women and their family members. The difficulty in carrying out preventive measures and treatment of patients consists in the polyetiology of habitual miscarriage. In half of the cases, disorders of immune mechanisms play a key role. It is the immune processes of the formation of this complication that have been widely reflected in the domestic and foreign literature, but most of them remain unsystematic. In this regard, the analysis of available data on changes in the immune response in women with habitual miscarriage, in comparison with patients whose pregnancy proceeded physiologically, was carried out. It is considered how the ratio of the main cells of the placental bed changes throughout pregnancy. Changes in the number and function of immune cells at both the systemic and local levels are presented. Data on the state of innate immunity in women with habitual miscarriage, including changes in the process of apoptosis, are presented. The most important mechanisms of cytokine regulation of pregnancy progression are considered.

Keywords:

pregnancy

recurrent pregnancy loss

monocytes

Authors:

Malyshkina A.I.

Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical Academy

SPIN RSCI: 7937-9125
Scopus AuthorID: 7801326390
ResearcherID: B-5680-2017
ORCID: 0000-0002-1145-0563

Sotnikova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical Academy

SPIN RSCI: 9156-4925
Scopus AuthorID: 7003525779
ResearcherID: A-9987-2017
ORCID: 0000-0002-0608-0692

Talanova I.E.

Ivanovo State Medical Academy

ORCID: 0000-0003-4950-8174

Kolesnikova A.M.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

ORCID: 0000-0001-8032-4635

Received:

10.03.2023

Accepted:

04.05.2023

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