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Pestova T.I.
GBUZ «OPTS»
Koloda Yu.A.
OOO «Reproduction Center «Line of Life»;
Russian Medical Academy of Continuous Professional Education
Boyarskij K.Yu.
North-Western State Medical University named after I.I. Mechnikov;
Center of Human Reproduction «Genesis»
Denisova Yu.V.
Russian Medical Academy of Continuous Professional Education;
Pletnev City Clinical Hospital
Regulatory control of gestagens use in Russia in the era of individualized luteal phase support for assisted reproduction cycles
Journal: Russian Journal of Human Reproduction. 2024;30(4): 59‑70
Views: 550
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To cite this article:
Pestova TI, Koloda YuA, Smirnova AA, L’vova AG, Boyarskij KYu, Denisova YuV. Regulatory control of gestagens use in Russia in the era of individualized luteal phase support for assisted reproduction cycles. Russian Journal of Human Reproduction.
2024;30(4):59‑70. (In Russ.)
https://doi.org/10.17116/repro20243004159
Approximately 12-18% of couples are infertile, according to WHO for the last 20 or 30 years. The most effective approach in the infertility treatment is assisted reproductive technology (ART). Despite the active development of this area and the constant improvement of the existing protocols, the gap between the pregnancy rate and the live birth rate reaches almost 30%. One of the serious difficulties standing in the way of the achieving a better reproductive outcome is the lag of the regulatory framework from the amount for some aspect’s elaboration, for example, the gestagens use for ART in Russia. The purpose of this review is to accumulate the latest data on the luteal phase support individualization in the post-transfer period based on biomarker — serum progesterone level, to analyze possible ways to overcome insurance and expert risks when using unregulated progesterone doses and dosage regimens, to emphasize the need for continuity in luteal phase support and pregnancy after ART to ensure the increase in the main criterion of ART effectiveness — live birth.
Keywords:
Authors:
Pestova T.I.
GBUZ «OPTS»
Koloda Yu.A.
OOO «Reproduction Center «Line of Life»;
Russian Medical Academy of Continuous Professional Education
Boyarskij K.Yu.
North-Western State Medical University named after I.I. Mechnikov;
Center of Human Reproduction «Genesis»
Denisova Yu.V.
Russian Medical Academy of Continuous Professional Education;
Pletnev City Clinical Hospital
Received:
29.05.2024
Accepted:
30.07.2024
List of references:
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