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Ilina I.Yu.

Pirogov Russian National Research Medical University

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Burdin D.V.

Features of the course of pregnancy and childbirth in patients with uterine fibroids after treatment and without it

Authors:

Ilina I.Yu., Dobrokhotova Yu.E., Burdin D.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2023;29(3): 61‑69

DOI: 10.17116/repro20232903161

Views: 3103

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To cite this article:

Ilina IYu, Dobrokhotova YuE, Burdin DV. Features of the course of pregnancy and childbirth in patients with uterine fibroids after treatment and without it. Russian Journal of Human Reproduction. 2023;29(3):61‑69. (In Russ.)
https://doi.org/10.17116/repro20232903161

Подписка 2025 (Russian Journal of Human Reproduction)
 
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Uterine fibroids are a common disease that is found in almost 80—90% of women under the age of 50, observed according to various sources in 20—70% of women of reproductive age, and occurs in 0.5—6% of cases during pregnancy. In some cases, uterine fibroids do not prevent the onset of pregnancy and fetal development, however, they can increase the frequency of complications of pregnancy and childbirth, in addition, they can cause infertility. The effect of fibroids on the onset of pregnancy is determined by the localization, size and number of nodes. The modern view of the treatment of uterine fibroids includes wait-and-see tactics, medical and surgical treatment, as well as interventional radiological manipulations. Since currently the age of women planning pregnancy is generally increasing, there is a growing need for minimally invasive and sparing methods of surgical treatment of uterine fibroids. The main direction of modern organ-preserving surgical methods for the treatment of fibroids is tumor enucleation with subsequent closure of the incision of the uterus. Currently, a fairly large number of studies are being conducted aimed at determining the presence or absence of advantages of laparoscopic, hysteroscopic and laparotomic myomectomy. For women who want to preserve their uterus and who have not had a response to medication, relapses after myomectomy, embolization of the uterine arteries may be recommended. Each method has its advantages, but also possible complications. What kind of treatment can lead to the optimal result, ensure the highest quality of life, the least number of complications, reduction of symptoms and the least likelihood of intervention, has not been established to date and may depend on many factors and careful selection of patients.

Keywords:

uterine fibroids
myomectomy
uterine artery embolization
pregnancy
uterine rupture
pregnancy complications

Authors:

Ilina I.Yu.

Pirogov Russian National Research Medical University

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Burdin D.V.

Received:

28.09.2022

Accepted:

06.10.2022

List of references:

  1. Adamyan LV, Serov VN, Suhih GT. Obstetrics and gynecology: Clinical recommendations. Problemy reprodukcii. 2017;23(S3):466-515. (In Russ.).
  2. Yarmolinskaya MI, Ivashchenko TE, Kusevickaya MB, Osinovskaya NS. Analysis of the polymorphism of the MMR1 gene depending on the clinical features of the course of uterine fibroids. Problemy reprodukcii. 2020;26(1):73-82. (In Russ.). https://doi.org/10.17116/repro20202601173
  3. Kashani BN, Centini G, Morelli SS, Weiss G, Petraglia F. Role of Medical Management for Uterine Leiomyomas. Best Practice and Research. Clinical Obstetrics and Gynaecology. 2016;34:85-103.  https://doi.org/10.1016/j.bpobgyn.2015.11.016
  4. Marsh EE, Al-Hendy A, Kappus D, Galitsky A, Stewart EA, Kerolous M. Burden, Prevalence, and Treatment of Uterine Fibroids: A Survey of U.S. Women. Journal of Womens Health. 2018;27(11): 1359-1367. https://doi.org/10.1089/jwh.2018.7076
  5. Kozachenko AV, Buyanova SN, Krasnova IA. Pregnancy and uterine fibroids. Akusherstvo i ginekologiya. Novosti. Mneniya. Obucheniye. 2015;2(8):61-66. (In Russ.).
  6. Mioma matki. Klinicheskie rekomendacii. 2020. (In Russ.).
  7. Yashchuk AG, Musin II, Gumerova IA. Modern aspects in the study of the etiology of uterine fibroids. Rossijskij vestnik akushera-ginekologa. 2019;19(3):49-56. (In Russ.). https://doi.org/10.17116/rosakush20191903149
  8. Donnez J, Dolmans MM. Uterine fibroid management: from the present to the future. Human Reproduction Update. 2016;22:665-686.  https://doi.org/10.1093/humupd/dmw023
  9. Grube M, Neis F, Brucker SY, Kommoss S, Andress J, Weiss M, Hoffmann S, Taran FA, Krämer B. Uterine Fibroids — Current Trends and Strategies. Surgical Technology International. 2019;15(34): 257-263. 
  10. Stewart EA, Cookson CL, Gandolfo RA, Schulze-Rath R. Epidemiology of uterine fibroids: a systematic review. BJOG International Journal of Obstetrics and Gynecology. 2017;124(10):1501-1512. https://doi.org/10.1111/1471-0528.14640
  11. Levakov SA, Azadova GYa, Mamedova AE, Il’ina OV, Luchin IA Sovremennyj vzglyad na etiopatogenez miomy matki. Nauka Rossii: celi i zadachi. Sbornik nauchnyh trudov po materialam XXVIII mezhdunarodnoj nauchnoj konferencii. Chast’ 1. Ekaterinburg: NIC «L-ZHurnal»; 2021;18-23. (In Russ.). https://doi.org/10.18411/sr-10-08-2021-03
  12. De La Cruz MS, Buchanan EM. Uterine Fibroids: Diagnosis and Treatment. American Family Physician. 2017;95(2):100-107. 
  13. Giuliani E, As-Sanie S, Marsh EE. Epidemiology and management of uterine fibroids. International Journal of Gynaecology and Obstetrics. 2020;149(1):3-9.  https://doi.org/10.1002/ijgo.13102
  14. Middelkoop MA, Harmsen MJ, Manyonda I, Mara M, Ruuskanen A, Daniels J, Mol BWJ, Moss J, Hehenkamp WJK, Wu O. Uterine artery embolization versus surgical treatment in patients with symptomatic uterine fibroids: Protocol for a systematic review and meta-analysis of individual participant data. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2021;256:179-183.  https://doi.org/10.1016/j.ejogrb.2020.11.027
  15. Pogorelova TN, Gun’ko VO, Ermolova NV, Kartashova AV, Durnicyea OA, Allilueva IA. The importance of proteolytic and oxidative destruction of proteins in the development of uterine fibroids. Rossijskij vestnik akushera-ginekologa. 2019;19(2):42-46. (In Russ.). https://doi.org/10.17116/rosakush20191902142
  16. Kubik-Huch RA, Weston M, Nougaret S, Leonhardt H, Thomassin-Naggara I, Horta M, Cunha TM, Maciel C, Rockall A, Forstner R. European Society of Urogenital Radiology (ESUR) guidelines: MR imaging of leiomyomas. European Radiology. 2018;28(8): 3125-3137. https://doi.org/10.1007/s00330-017-5157-5
  17. Suzuki A, Aoki M, Miyagawa C, Murakami K, Takaya H, Kotani Y, Nakai H, Matsumura N. Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma Using Magnetic Resonance Images: A Literature Review. Healthcare. Multidisciplinary Digital Publishing Institute. 2019;7(4):158.  https://doi.org/10.3390/healthcare7040158
  18. Levine DJ, Berman JM, Harris M, Chudnoff SG, Whaley FS, Palmer SL. Sensitivity of myoma imaging using laparoscopic ultrasound compared with magnetic resonance imaging and transvaginal ultrasound. Journal of Minimally Invasive Gynecology. 2013;20(6):770-774.  https://doi.org/10.1016/j.jmig.2013.04.015
  19. Babunashvili EL, Shchukina NA, Buyanova SN, Budykina TS, Tihomirova EV, Glebov TA, Son DYu, Kocuba DR. Possibilities of rehabilitation of patients of reproductive age after myomectomy. Rossijskij vestnik akushera-ginekologa. 2022;22(3):93-99. (In Russ.). https://doi.org/10.17116/rosakush20222203193
  20. McWilliams MM, Chennathukuzhi VM. Recent advances in uterine fibroid etiology. Seminars in Reproductive Medicine. 2017;35(2): 181-189.  https://doi.org/10.1055/s-0037-1599090
  21. Patel A, Malik M, Britten J, Cox J, Catherino WH. Mifepristone inhibits extracellular matrix formation in uterine leiomyoma. Fertility and Sterility. 2016;105(4):1102-1110. https://doi.org/10.1016/j.fertnstert.2015.12.021
  22. Revazova ZV, Manukyan LM, Arslanyan KN, Loginova ON. Modern tactics of preoperative preparation of patients before laparoscopic myomectomy. Colloquium-journal. 2019;(3)51:59-63. (In Russ.).
  23. Dobrohotova YuE, Il’ina IYu. Uterine fibroids in premenopausal patients. Medicinskij sovet. 2019;13:123-128. (In Russ). https://doi.org/10.21518/2079-701X-2019-13-123-128
  24. Dobrohotova YuE, Il’ina IYu, Ibragimova DM, Narimanova MR. Uterine fibroids: alternative methods of treatment. Problemy reprodukcii. 2018;24(2):83-87. (In Russ.). https://doi.org/10.17116/repro201824283-87
  25. Buyanova SN, Shchukina NA, CHechneva MA, Babunashvili EL, Yudina NV, Gukasyan SA. Atypical uterine fibroids in young women: diagnosis, treatment, rehabilitation. Rossijskij vestnik akushera-ginekologa. 2019;19(6):77-83. (In Russ.). https://doi.org/10.17116/rosakush20191906177
  26. Tinelli A, Malvasi A. Uterine myoma, myomectomy and Minimally invasive treatments. Luxembourg: Springer International Publishing; 2014. https://doi.org/10.1007/978-3-319-10305-1
  27. Jefferys A, Akande V. Modern management of fibroids. Gynaecology and Obstetrics. Reproductive Medicine. 2016;26(5):127-132.  https://doi.org/10.1016/j.ogrm.2016.02.004
  28. Hashukoeva AZ, Suhova TN, Rzaeva RA, Moseshvili GG. A new method of conservative treatment of uterine fibroids. Lechashhij vrach. 2017;3:30-34. (In Russ.).
  29. Badmaev SZh, Ckhaj VB, Kaplunov VA, Narkevich AN. Comparative analysis of the effectiveness of various types of drug prevention of recurrent uterine fibroids in patients of reproductive age who underwent myomectomy. Sibirskoe medicinskoe obozrenie. 2020;4(124): 77-83. (In Russ.). https://doi.org/10.20333/2500136-2020-4-77-83
  30. Zajdieva YaZ, Gulieva LN. Treatment of patients with uterine fibroids during menopausal transition. Rossijskij vestnik akushera-ginekologa. 2020;4(124):77-83. (In Russ.). https://doi.org/10.17116/rosakush20202001132
  31. Krasnopol’skij VI, Buyanova SN, Shchukina NA, Popov AA. Operativnaya ginekologiya. M.: MEDpress-inform; 2018. (In Russ).
  32. Kotami Y, Tobiume T, Fujishima R, Matsumura N. Recurrence of uterine myoma after myomectomy: Open myomectomy versus laparoscopic myomectomy: Recurrence after laparotomy vs LM. Journal of Obstetrics and Gynaecology Research. 2018;44:2:298-302.  https://doi.org/10.1111/jog.13519
  33. Islam MS, Ciavattini A, Petraglia F. Extracellular matrix in uterine leiomyoma pathogenesis: a potential target for future therapeutics. Human Reproduction Update. 2018;24:1:59-85.  https://doi.org/10.1093/humupd/dmx032
  34. Zupi E, Centini G, Sabbioni L, Lazzeri L, Argay IM, Petraglia F. Nonsurgical alternatives for uterine fibroids. Best Practice and Research. Clinical Obstetrics and Gynaecology. 2016;34:122-131.  https://doi.org/10.1016/j.bpobgyn.2015.11.013
  35. Andreeva EN, Ryabinkina TS, Ryzhova TE. The Ministry of Health strongly recommends. Review of a new clinical protocol for the diagnosis and treatment of uterine fibroids. Status Praesens. 2016;2: 31:1-50. (In Russ).
  36. Zeghal D, Ayachi A, Mahjoub S, Boulahya G, Zakraoui A, Ben Hmid R, Zouari F. Fibroids and pregnancy: complications. La Tunisie Medicale. 2012;90(4):286-290. 
  37. Bojko VI, Terekhov VA. Differentiated approach to surgical treatment of large uterine fibroids. Zdorov’e zhenshhiny. 2016;7(113):57. (In Russ).
  38. Karavaev YuE, Arslanyan KN, Loginova ON. Features of the course of pregnancy and childbirth in patients with a scar on the uterus after reconstructive plastic surgery performed by different approaches. Lechashhij vrach. 2019;8:68. (In Russ).
  39. Davydov AI, SHahlamova MN, Pashkov VM. Uterine leiomyoma in the reproductive period. Treatment strategy. Voprosy` ginekologii, akusherstva i perinatologii. 2020;19(1):143-150.  https://doi.org/10.20953/1726-1678-2020-1-143-150
  40. Iavazzo C, Mamais I, Gkegkes ID. Robotic assisted vs laparoscopic and/or open myomectomy: systematic review and meta-analysis of the clinical evidence. Archives of Gynecology and Obstetrics. 2016; 294(1):5-17.  https://doi.org/10.1007/s00404-016-4061-6
  41. Gumerova IA. Retrospective analysis of pregnancy outcomes in women with uterine fibroids. Tribuna uchenogo. 2020;9:407-413. (In Russ).
  42. Ahmad G, O’Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. The Cochrane Database of Systematic Reviews. 2015;4:CD000475. https://doi.org/10.1002/14651858.CD000475.pub3
  43. Dubin AK, Wei J, Sullivan S, Udaltsova N, Zaritsky E, Yamamoto MP. Minilaparotomy Versus Laparoscopic Myomectomy After Cessation of Power Morcellation: Rate of Wound Complications. Journal of Minimally Invasive Gynecology. 2017;24(6):946-953.  https://doi.org/10.1016/j.jmig.2017.05.010
  44. Tomczyk KM, Wilczak M, Rzymski P. Uterine rupture at 28 weeks of gestation after laparoscopic myomectomy — a case report. Menopause Review. 2018;17(2):101-104.  https://doi.org/10.5114/pm.2018.77314
  45. Kira EF, Politova AK, Gudebskaya VA, Kuz’michev VS. The role of laparoscopic robot-assisted myomectomy in restoring fertility in patients with uterine fibroids in the reproductive period. Akusherstvo i ginekologiya. 2016;3:58-63. (In Russ). https://doi.org/10.18565/aig.2016.3.58-63
  46. Gil Y, Badeghiesh A, Suarthana E, Mansour F, Capmas P, Volodarsky-Perel A, Tulandi T. Risk of uterine rupture after myomectomy by laparoscopy or laparotomy. Journal of Gynecology Obstetrics and Human Reproduction. 2020;49(8):101843. https://doi.org/10.1016/j.jogoh.2020.101843
  47. Mitichkin AE, Dobrohotova YuE, Ivannikov NYu, Dimitrova VI. Improvement of reproductive outcomes after surgical treatment of uterine fibroids. Medicinskij sovet. 2019;7:110-118. (In Russ). https://doi.org/10.21518/2079-701X-2019-7-110-118
  48. Daniels J, Middleton LJ, Cheed V, McKinnon W, Rana D. Uterine artery embolisation versus myomectomy for premenopausal women with uterine fibroids wishing to avoid hysterectomy: the FEMME RCT. Health Technology Assessment. 2022;26(22):1-74.  https://doi.org/10.3310/ZDEG6110
  49. Sharafutdinov BM, Antropova EYu, Ryzhkin SA, Mazitova MI, Abdul’yanov IV, Klyucharov IV. The effect of radiation load on ovarian ovarian reserve after uterine artery embolization. Voprosy’ ginekologii, akusherstva i perinatologii. 2020;19(3):22-29. (In Russ). https://doi.org/10.20953/1726-1678-2020-3-22-29
  50. Czuczwar P, Stepniak A, Milart P, Paszkowski T, Wozniak S. Comparison of the influence of three fibroid treatment options: Supracervical hysterectomy, ulipristal acetate and uterine artery embolization on ovarian reserve — an observational study. Journal of Ovarian Research. 2018;11:45.  https://doi.org/10.1186/s13048-018-0420-1
  51. Ghanaati H, Sanaati M, Shakiba M, Bakhshandeh H, Ghavami N, Aro S, Jalali AH, Firouznia K. Pregnancy and its Outcomes in Patients after Uterine Fibroid Embolization: A Systematic Review and Meta-Analysis. Cardiovascular and Interventional Radiology. 2020; 43(8):1122-1133. https://doi.org/10.1007/s00270-020-02521-6
  52. Ludwig PE, Huff TJ, Shanahan MM, Stavas JM. Pregnancy success and outcomes after uterine fibroid embolization: updated review of published literature. British Journal of Radiology. 2020; 93(1105):20190551. https://doi.org/10.1259/bjr.20190551
  53. Oleksik T.P., Pluta K., Issat T., Jakimiuk A., Wierzba W. The use of super-selective uterine artery branch embolization and methotrexate in cervical pregnancy — case reports and literature review. Annals of Agricultural and Environmental Medicine. 2021;28(3):521-524.  https://doi.org/10.26444/aaem/127926
  54. Mas A, Tarazona M, Dasí Carrasco J, Estaca G, Cristóbal I, Monleón J. Updated approaches for management of uterine fibroids. International Journal of Women’s Health. 2017;9:607-617.  https://doi.org/10.2147/IJWH.S138982
  55. Bradley LD, Pasic RP, Miller LE. Clinical Performance of Radiofrequency Ablation for Treatment of Uterine Fibroids: Systematic Review and Meta-Analysis of Prospective Studies. Journal of Laparoendoscopic and Advanced Surgical Techniques — Part A. 2019; 29(12):1507-1517. https://doi.org/10.1089/lap.2019.0550
  56. Jeldu M, Asres T, Arusi T, Gutulo MG. Pregnancy rate after myomectomy and associated factors among reproductive age women who had myomectomy at Saint Paul’s Hospital Millennium Medical College, Addis Ababa: retrospective cross-sectional study. International Journal of Reproductive Medicine. 2021;6680112. https://doi.org/10.1155/2021/6680112
  57. El Shamy T, Amer SA, Mohamed AA, James C, Jayaprakasan K. The impact of uterine artery embolization on ovarian reserve: A systematic review and meta-analysis. Acta Obstetricia et Gynecologica Scandinavica. 2020;99(1):16-23.  https://doi.org/10.1111/aogs.13698
  58. Savel’eva GM, Kurcer MA, Breslav IYu. Rupture of the uterus after a myomectomy performed outside of pregnancy. Voprosy ginekologii, akusherstva i perinatologii. 2021;20(6):5-11. (In Russ). https://doi.org/10.20953/1726-1678-2021-6-5-11
  59. Fox NS. Pregnancy Outcomes in Patients with Prior Uterine Rupture or Dehiscence: A 5-Year Update. Obstetrics and Gynaecology. 2020;135(1):211-212.  https://doi.org/10.1097/AOG.0000000000003622
  60. Gambacorti-Passerini Z, Penati C, Carli A, Accordino F, Ferrari L, Berghella V, Locatelli A. Vaginal birth after prior myomectomy. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2018;231:198-203.  https://doi.org/10.1016/j.ejogrb.2018.10.007

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