Morphological structure of the placenta as a result of its increment

Omarova Kh.M.; Omarova R.G.; Khashaeva T.Kh-M.; Magomedova I.Kh.; Rasulov M.T.

doi:https://doi.org/10.17116/repro202228011142

Omarova Kh.M.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Omarova R.G.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Khashaeva T.Kh-M.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Magomedova I.Kh.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Rasulov M.T.

Dagestan State Medical University

Morphological structure of the placenta as a result of its increment

Authors:

Omarova Kh.M., Omarova R.G., Khashaeva T.Kh-M., Magomedova I.Kh., Rasulov M.T.

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Journal: Russian Journal of Human Reproduction. 2022;28(1): 142‑148

DOI: 10.17116/repro202228011142

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To cite this article:

Omarova KhM, Omarova RG, Khashaeva TKh-M, Magomedova IKh, Rasulov MT. Morphological structure of the placenta as a result of its increment. Russian Journal of Human Reproduction. 2022;28(1):142‑148. (In Russ.)
https://doi.org/10.17116/repro202228011142

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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OBJECTIVE

To identify the histological features of placental tissue with an increment in pregnant women.

MATERIAL AND METHODS

A retrospective single-center cohort study was conducted on the basis of the Dagestan State Medical University. The results of the study of 43 sequels were analyzed: the 1st group consisted of 23 pregnant women with placenta increment, the 2nd control group was a group of 20 women with a physiologically occurring pregnancy.

RESULTS

All women of the 1st group were of the late reproductive period and 60% of them had varicose veins of the genitals. In the 1st group, smaller placenta sizes and weights were significantly more common than in the 2nd group. Adaptive changes are noted in the chorial tissue against the background of chronic circulatory disorders in the form of the development of ischemic infarcts in the placental tissue and fullness of chorionic villi in patients of the 1st group. Signs of placental dystrophy in the form of necrotized villi and a massive interstitial fibrinoid (with obliteration of the interstitial space) were visualized in the 1st group and were completely absent in the 2nd group. Sclerosis of the villi stroma was recorded in every second woman of the 1st group and very rarely in the 2nd group. Moderate involutive-dystrophic changes in the form of foci of fibrin deposition, syncytial kidneys, calcinates were statistically significantly more often observed in women of the 1st and less often in the 2nd group of the study.

CONCLUSION

It is shown that along with damage to the placenta structure in pregnant women, microcirculation disorders occur in the chorionic villi during increment, compensatory and adaptive reactions develop with hypervascularization phenomena and an increase in the area of the microcirculatory bed. It is possible that changes in the hormonal background of late reproductive age that occur in this category of women and disorders in the endothelial system with varicose veins confirm the participation of these factors in the formation of placental increment. However, further scientific research is necessary.

Keywords:

pregnancy

placenta

increment

varicose veins of the genitals

Authors:

Omarova Kh.M.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Omarova R.G.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Khashaeva T.Kh-M.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Magomedova I.Kh.

Dagestan State Medical University of the Ministry of Health of the Russian Federation

Rasulov M.T.

Dagestan State Medical University

Received:

05.09.2021

Accepted:

20.12.2021

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References:

Asankulov EK, Subanov DM, Teppeeva TKh, Omurbekova MM. Anomalies of placental attachment as a risk factor for obstetric bleeding. Vestnik KGMA im. I.K. Akhunbaeva. 2017;3:118-122. (In Russ.).
Korolev AYu, Pyregov AV, Fedorova TA, Shmakov RG, Gerasimov YuA, Shpilyuk MA, Medvedeva AA. Safety of regional anesthesia during delivery of pregnant women with placenta accrete. Akusherstvo i ginekologiya. 2019;1:92-97. (In Russ.). https://doi.org/10.18565/aig.2019.l.92-97
O’Brien B, Smoleneic J. Cervical varicosities and placenta praevia. The Australian and New Zealand Journal of Obstetrics and Gynaecology. 2013;53(5):451-454. https://doi.org/10.1111/ajo.12127
Kolchina VV, Azarova LV. The relationship of anomalies of the placenta location with factors of infectious genesis. Fundamental’nye issledovaniya. 2014;7(4):723-727. (In Russ.).
Silver RM. Abnormal Placentation: Placenta Previa, Vasa Previa, and Placenta Accreta. Obstetrics and Gynecology. 2015;126(3):654-668. https://doi.org/10.1097/AOG.0000000000001005
Chistyakova GN, Remizova II, Grishkina AA, Kayumova AV. Morphological and immunohistochemical features of placental tissue in anomalies of placental attachment. Rossijskij vestnik akushera-ginekologa. 2019;19(2):34-41. (In Russ.). https://doi.org/10.17116/rosakush20191902134
Khasanov AA. Diagnostics, prevention and organ-preserving methods of delivery of pregnant women with placenta accreta. Kazanskij meditsinskij zhurnal. 2016;97(4):477-485. (In Russ.). https://doi.org/10.17750/KMJ2015-477
Kurtser MA, Lukashina MV, Panin AV, Shtabnitsky AM, Alekseeva TV, Breusenko LE, Breslav IYu. True placenta regrowth. Organ-preserving operations. Voprosy ginekologii, akusherstva i perinatalogii. 2009;8(5):31-35. (In Russ.).
Kim SM, Kim JS. A Review of Mechanisms of Implantation. Development and Reproduction. 2017;21(4):351-359. https://doi.org/10.12717/DR.2017.21.4.351
Bilban M, Ghaffari-Tabrizi N, Hintermann E, Bauer S, Molzer S, Zoratti C, Malli R, Sharabi A, Hiden U, Graier W, Knöfler M, Andreae F, Wagner O, Quaranta V, Desoye G. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. Journal of Cell Science. 2004;117(Pt 8):1319-1328. https://doi.org/10.1242/jcs.00971
Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411(6837):613-617. https://doi.org/10.1038/35079135
Stoyko YuM, Gudymovich VG, Trifonov SI, Nikitina AM, Nikitin MN. Endothelial dysfunction in patients with chronic venous insufficiency of the lower extremities and the possibility of its correction. Novosti khirurgii. 2010;18(4):57-65. (In Russ.).
Gereikhanova EG, Omarova KhM, Khashaeva TKh-M, Ibragimova ES-A, Magomedova IKh, Omarova RG. Morphological features of the placenta of maternity hospitals with varicose veins of the genitals. Morfologiya. 2020;158(4-5):72-77. (In Russ.). https://doi.org/10.34922/AE.2020.158.4.011
Omarova KhM. The state of the fetoplacental complex in patients with varicose veins who have become very expensive. Zhurnal akusherstva i zhenskikh boleznej. 2008;LVII(2):68-72. (In Russ.).