«Cytokine storm» as an immunopathologic reaction in pregnant women in the first trimester

Lyashenko E.N.; Aramyan E.E.; Zinchenko M.S.

doi:https://doi.org/10.17116/rosakush20242405119

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Abstract:

«Cytokine storm» is an immunopathologic reaction in which under the action of certain triggers, among which viruses are of great importance, there is an uncontrolled release of proinflammatory cytokines into the blood, which, in turn, lead to homeostasis disorders and the development of complications of the body during the period of greatest exposure to these peptides. The first trimester of pregnancy is such a period, as it is the time when the main organs and systems of the embryo are being laid and after 8 weeks of pregnancy — of the fetus, in this connection any exo- or endogenous influence can lead to disorders of proliferation and differentiation of cells of the embryo or fetus. Therefore, the study of aspects of the course of “cytokine storm” and methods of its correction in pregnant women in the first trimester occupies a special place in obstetrics at the moment.«cytokine storm» correction.

Keywords:

«cytokine storm»

pregnancy

I trimester

interleukins

COVID-19

correction of the «cytokine storm»

Authors:

Lyashenko E.N.

V.I. Vernadsky Crimean Federal University — S.I. Georgievsky Red Banner Medical Institute

ORCID: 0000-0002-4350-5020

Aramyan E.E.

V.I. Vernadsky Crimean Federal University — S.I. Georgievsky Red Banner Medical Institute

ORCID: 0000-0002-4130-4778

Zinchenko M.S.

V.I. Vernadsky Crimean Federal University — S.I. Georgievsky Red Banner Medical Institute

ORCID: 0000-0002-3720-8644

Received:

22.02.2024

Accepted:

13.03.2024

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References:

Potapnev M.P. Cytokine storm: causes and consequences. Immunologiya. 2021;42:2:175-188. (In Russ.).
Tyulyandina E.V., Piskov D.A. Cytokine storm: Features of pathogenesis, role in the development of viral infection. Ustoichivoe razvitie nauki i obrazovaniya. 2019;1:256-260. (In Russ.).
Kostyuk S.A., Simirskii V.V., Gorbich Yu.L., Anis’ko L.A., Poluyan O.S. Cytokine storm in COVID-19. Meditsinskie novosti. 2020;10:313:4-8.
Sakhautdinova I.V., Zasyadkin I.S., Tayupova I.M., Khaibullina A.R. The effect of the new coronavirus infection COVID-19 on the immunological status of pregnant women. Ural’skii meditsinskii zhurnal. 2022;21:4:72-77. (In Russ.).
Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020;383:23:2255-2273. https://doi.org/10.1056/NEJMra2026131
Tang XD, Ji TT, Dong JR, Feng H, Chen FQ, Chen X, Zhao HY, Chen DK, Ma WT. Pathogenesis and treatment of cytokine storm induced by infectious diseases. Int J Mol Sci. 2021;22:23:13009. https://doi.org/10.3390/ijms222313009
Nile SH, Nile A, Qiu J. Li L, Jia X, Kai G. COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons. Cytokine Growth Factor Rev. 2020;53:66-70. https://doi.org/10.1016/j.cytogfr.2020.05.002
Ye Q, Wang B, Mao J. The pathogenesis and treatment of the `Cytokine Storm’ in COVID-19. J Infect. 2020;80:6:607-613. https://doi.org/10.1016/j.jinf.2020.03.037
Tereshchenko I.V., Kayushev P.E. Tumor necrosis factor α and its role in pathology. RMZh. Meditsinskoe obozrenie. 2022;6:9:523-527. (In Russ.). https://doi.org/10.32364/2587-6821-2022-6-9-523-527
Obstetrics. Ed. G.M. Savel’eva. M.: Meditsina. 2000;83-85. (In Russ.).
Naidu SAG, Clemens RA, Pressman P, Zaigham M, Kadkhoda K, Davies KJA, Naidu AS. COVID-19 during pregnancy and postpartum. J Diet Suppl. 2022;19:1:115-142. https://doi.org/10.1080/19390211.2020.1834049
Obuchowska A, Standyło A, Obuchowska K, Kimber-Trojnar Ż, Leszczyńska-Gorzelak B. Cytokine storms in the course of COVID-19 and haemophagocytic lymphohistiocytosis in pregnant and postpartum women. Biomolecules. 2021;11:8:1202. https://doi.org/10.3390/biom11081202
Figueiredo CP, Fontes-Dantas FL, da Poian AT, Clarke JR. SARS-CoV-2-associated cytokine storm during pregnancy as a possible risk factor for neuropsychiatric disorder development in post-pandemic infants. Neuropharmacology. 2021;201:108841. https://doi.org/10.1016/j.neuropharm.2021.108841
Gashimova N.R., Pankrat’eva L.L., Bitsadze V.O., Khizroeva D.Kh., Makatsariya N.A., Tret’yakova M.V., Shkoda A.S., Grigor’eva K.N., Tsibizova V.I., Gri Zh.K., Yakubova F.E., Blinov D.V., Makatsariya A.D. Intrauterine activation of the fetal immune system in response to COVID-19 in the mother. Akusherstvo, ginekologiya i reproduktsiya. 2023;17:2:188-201. (In Russ.).
Wenling Y, Junchao Q, Xiao Z, Ouyang S. Pregnancy and COVID-19: management and challenges. Rev Inst Med Trop Sao Paulo. 2020;62:e62. https://doi.org/10.1590/s1678-9946202062062
Kumar R, Yeni CM, Utami NA, Masand R, Asrani RK, Patel SK, Kumar A, Yatoo MI, Tiwari R, Natesan S, Vora KS, Nainu F, Bilal M, Dhawan M, Emran TB, Ahmad T, Harapan H, Dhama K. SARS-CoV-2 infection during pregnancy and pregnancy-related conditions: Concerns, challenges, management and mitigation strategies-a narrative review. J Infect Public Health. 2021;14:7:863-875. https://doi.org/10.1016/j.jiph.2021.04.005
Mereke A., Oralkhan Zh., Zhurabekova G. The effectiveness of treatment and CURE OF SARS-COV-2. West Kazakhstan Medical Journal. 2022;1:64:4-8. (In Russ.). https://doi.org/10.24412/2707-6180-2022-64-4-8
Vesce F, Battisti C, Crudo M. The Inflammatory cytokine imbalance for miscarriage, pregnancy loss and COVID-19 pneumonia. Front Immunol. 2022;13:861245. https://doi.org/10.3389/fimmu.2022.861245
Grigor’eva E.V., Tyapkina D.A., Borodai A.A., Blokhin I.S., Kondrashkin I.E., Polidanov M.A., Rebrov A.P. On the effectiveness of COVID-19 treatment in pregnant women. Clinician. 2023;17:2:28-38. (In Russ.).
Tanacan A, Yazihan N, Erol SA, Anuk AT, Yucel Yetiskin FD, Biriken D, Ozgu-Erdinc AS, Keskin HL, Moraloglu Tekin O, Sahin D. The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study. Cytokine. 2021;140:155431. https://doi.org/10.1016/j.cyto.2021.155431
Vukolova V.A., En’kova E.V., Ryzhikov Yu.S., Sokol E.B., Ippolitova L.I., Kiseleva E.V., Korzh E.V. Assessment of the course of pregnancy, childbirth and fetal condition in women with COVID-19. Vestnik novykh meditsinskikh tekhnologii. Electronic Edition. 2020;14:6:56-62. (In Russ.). https://doi.org/10.24411/2075-4094-2020-16778
Lan X, Guo L, Zhu S, Cao Y, Niu Y, Han S, Li Z, Li Y, Yan J. First-trimester serum cytokine profile in pregnancies conceived after assisted reproductive technology (ART) with subsequent pregnancy-induced hypertension. Front Immunol. 2022;13:930582. https://doi.org/10.3389/fimmu.2022.930582
Lyazgiyan K.S. Clinical and immunological features of the new coronavirus infection SARS-CoV-2 in pregnant women. Byulleten’ fisiologii i patologii dykhaniya. 2021;80:91-99. (In Russ.).
Khandaker GM, Cousins L, Deakin J, Lennox BR, Yolken R, Jones PB. Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. Lancet Psychiatry. 2015;2:258-270.
Granja MG, Oliveira ACDR, de Figueiredo CS, Gomes AP, Ferreira EC, Giestal-de-Araujo E, de Castro-Faria-Neto HC. SARS-CoV-2 infection in pregnant women: Neuroimmune-endocrine changes at the maternal-fetal interface. Neuroimmunomodulation. 2021;28:1:1-21. https://doi.org/10.1159/000515556
Thepmankorn P, Bach J, Lasfar A, Zhao X, Souayah S, Chong ZZ, Souayah N. Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations. Cytokine. 2021;138:155404. https://doi.org/10.1016/j.cyto.2020.155404
Veleri S. Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients. Exp Brain Res. 2022;240:1:9-25. https://doi.org/10.1007/s00221-021-06244-z
Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. Am J Obstet Gynecol. 2022;226:2:177-186. https://doi.org/10.1016/j.ajog.2021.08.054
Quincozes-Santos A, Rosa RL, Tureta EF, Bobermin LD, Berger M, Guimarães JA, Santi L, Beys-da-Silva WO. COVID-19 impacts the expression of molecular markers associated with neuropsychiatric disorders. Brain Behav Immun Health. 2021;11:100196. https://doi.org/10.1016/j.bbih.2020.100196
Ayed M, Embaireeg A, Kartam M, More K, Alqallaf M, AlNafisi A, Alsaffar Z, Bahzad Z, Buhamad Y, Alsayegh H., Al-Fouzan W, Alkandari H. Neurodevelopmental outcomes of infants born to mothers with SARS-CoV-2 infections during pregnancy: a national prospective study in Kuwait. BMC Pediatr. 2022;22:1:319. https://doi.org/10.1186/s12887-022-03359-2
Gareeva A.E. Modern view on neurobiological hypotheses of schizophrenia. Zhurnal vysshei nervnoi deyatel’nosti im. I.P. Pavlova. 2019:69:4:437-455. (In Russ.). https://doi.org/10.1134/S0044467719040038
Maksimova N.M., Bulgakova T.S., Uzbekov M.G. The role of cytokines in the pathogenesis and therapy of mental disorders. Sotsial’naya i klinicheskaya psikhiatriya. 2019;29:3:71-77. (In Russ.).
Joma M, Fovet CM, Seddiki N, Gressens P, Laforge M. COVID-19 and pregnancy: Vertical transmission and inflammation impact on newborns. Vaccines (Basel). 2021;9:4:391. https://doi.org/10.3390/vaccines9040391
Kalimatova D.M., Dobrokhotova Yu.E. Features of the course of pregnancy and childbirth in COVID-19 infection. Prakticheskaya meditsina. 2020;18:2:6-11. (In Russ.).
Yuldasheva G.R., Ismoilova Sh.T., Dzhabbarova Yu.K., Musakhodzhaeva D.A. The influence of a new COVID-19 viral infection on a pregnant woman, fetus and newborn. Zhurnal teoreticheskoi i klinicheskoi meditsiny. 2021;4:133-138. (In Russ.).
Jarmund AH, Giskeødegård GF, Ryssdal M, Steinkjer B, Stokkeland LMT, Madssen TS, Stafne SN, Stridsklev S, Moholdt T, Heimstad R, Vanky E, Iversen AC. Cytokine patterns in maternal serum from first trimester to term and beyond. Front Immunol. 2021;12:752660. https://doi.org/10.3389/fimmu.2021.752660
Norooznezhad AH, Shamshirsaz AA, Hantoushzadeh S. Labor could increase systemic inflammation and cause or deteriorate cytokine storm in COVID-19. Iran J Immunol. 2022;19:3:330-336. https://doi.org/10.22034/iji.2022.93951.2267
Trinh IV, Desai SP, Ley SH, Mo Z, Sato R, Pridjian GC, Longo SA, Shaffer JG, Robinson JE, Norton EB, Piedimonte G. Prenatal infection by respiratory viruses is associated with immuno-inflammatory responses in the fetus. Am J Respir Crit Care Med. 2023. https://doi.org/10.1164/rccm.202308-1461OC
Tsvetov V.M., Mirzaev K.B. Clinical and pharmacological aspects of the use of medicines in COVID-19 in pregnant women. Farmateka. 2020;27:14:16-27. (In Russ.). https://doi.org/10.18565/pharmateca.2020.14.16-27
Chen G, Liao Q, Ai J, Yang B, Bai H, Chen J, Liu F, Cao Y, Liu H, Li K. Immune Response to COVID-19 during pregnancy. Front Immunol. 2021;12:675476. https://doi.org/10.3389/fimmu.2021.675476
Ershov A.V., Surova V.D., Dolgikh V.T., Dolgikh T.I. Cytokine storm in a new coronavirus infection and ways to correct it. Antibiotiki i khimioterapiya. 2020;65:11-12:27-37. (In Russ.).
Jiménez-Lozano I, Caro-Teller JM, Fernández-Hidalgo N, Miarons M, Frick MA, Batllori Badia E, Serrano B, Parramon-Teixidó CJ, Camba-Longueira F, Moral-Pumarega MT, San Juan-Garrido R, Cabañas Poy MJ, Suy A, Gorgas Torner MQ. Safety of tocilizumab in COVID-19 pregnant women and their newborn: A retrospective study. J Clin Pharm Ther. 2021;46:4:1062-1070. https://doi.org/10.1111/jcpt.13394
Peng J, Fu M, Mei H, Zheng H. Liang G, She X, Wang Q, Liu W. Efficacy and secondary infection risk of tocilizumab, sarilumab and anakinra in COVID-19 patients: A systematic review and meta-analysis. Rev Med Virol. 2022;32:3:e2295. https://doi.org/10.1002/rmv.2295
Vasilevskii I.V. The role of cytokines in SARS-CoV-2 infection and cytokine storm blockade pathways. Healthcare (Minsk). 2022;3:900:31-41. (In Russ.).