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Isakova E.V.

International center for reproductive medicine

Savina V.A.

International center for reproductive medicine

Thin endometrium in ART treatment and outcome (literature review , part 2)

Authors:

Isakova E.V., Savina V.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2021;27(2): 65‑75

Read: 6558 times


To cite this article:

Isakova EV, Savina VA. Thin endometrium in ART treatment and outcome (literature review , part 2). Russian Journal of Human Reproduction. 2021;27(2):65‑75. (In Russ.)
https://doi.org/10.17116/repro20212702165

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References:

  1. Edwards RG. Human implantation: the last barrier in assisted reproduction technologies? Reproductive BioMedicine Online. 2006; 13(6):887-904.  https://doi.org/10.1016/s1472-6483(10)61039-5
  2. Wilcox AJ, Baird DD, Weinberg CR. Time of Implantation of the Conceptus and Loss of Pregnancy. New English Journal of Medicine. 1999;340(23):1796-1799. https://doi.org/10.1056/NEJM199906103402304
  3. Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, Broekmans FJ. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Human Reproduction Update. 2014;20(4):530-541.  https://doi.org/10.1093/humupd/dmu011
  4. Mouhayar Y, Sharara FI. Modern management of thin lining. Middle East Fertility Society Journal. 2016;22(1):1-12.  https://doi.org/10.1016/j.mefs.2016.09.001
  5. Mouhayar Y, Sharara FI. G-CSF and stem cell therapy for the treatment of refractory thin lining in assisted reproductive technology. Journal of Assisted Reproduction and Genetics. 2017;34(7):831-837.  https://doi.org/10.1007/s10815-017-0922-6
  6. Qin JB, Sheng XQ, Wu D, Gao SY, You YP, Yang TB, Wang H. Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics. 2017;295(2):285-301.  https://doi.org/10.1007/s00404-016-4250-3
  7. De Geyter C, De Geyter M, Steimann S, Zhang H, Holzgreve W. Comparative birth weights of singletons born after assisted reproduction and natural conception in previously infertile women. Human Reproduction. 2006;21(3):705-712.  https://doi.org/10.1093/humrep/dei378
  8. Mouhayar Y, Franasiak JM, Sharara F.I. Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review. Journal of Assisted Reproduction and Genetics. 2019; 36(4):607-611.  https://doi.org/10.1007/s10815-019-01407-y
  9. Chen S, Wu F, Lou C, Chen X, Shi X, Zheng HY, Ni YP. Combined analysis of endometrial thickness and pattern in predicting outcome of in vitro fertilization and embryo transfer: a retrospective cohort study. Journal of Reproductive Biology and Endocrinology. 2010;8:30.  https://doi.org/10.1186/1477-7827-8-30
  10. Yang W, Zhang T, Li Z, Ren X, Huang B, Zhu G, Jin L. Combined analysis of endometrial thickness and pattern in predicting clinical outcomes of frozen embryo transfer cycles with morphological good-quality blastocyst: a retrospective cohort study. Medicine. 2018; 97(2):e9577. https://doi.org/10.1097/MD.0000000000009577
  11. Liu KE, Hartman M, Hartman A, Luo Z-C, Mahutte N. The impact of a thin endometrial lining on fresh and frozen — thaw IVF outcomes: an analysis of over 40 000 embryo transfers. Human Reproduction. 2018;33(10):1883-1888. https://doi.org/10.1093/humrep/dey281
  12. Yuan X, Saravelos SH,Wang Q, Xu Y, Li TC, Zhou C. Endometrial thickness as a predictor of pregnancy outcomes in 10787 fresh IVF—ICSI cycles. Reproductive BioMedicine Online. 2016;33(2):197-205.  https://doi.org/10.1016/j.rbmo.2016.05.002
  13. Baradwan S, Shafi D, Baradwan A, Bashir MS, Al-Jaroudi D. The effect of endometrial thickness on pregnancy outcome in patients with Asherman’s syndrome post-hysteroscopic adhesiolysis. Internationale Journal of Women’s Health. 2018;10:77-82.  https://doi.org/10.2147/IJWH.S151283
  14. Ma NZ, Chen L, Dai W, Bu ZQ, Hu LL, Sun YP. Influence of endometrial thickness on treatment outcomes following in vitro fertilization/intracytoplasmic sperm injection. Reproductive Biology and Endocrinology. 2017;15(1):5.  https://doi.org/10.1186/s12958-016-0222-5
  15. Kumbak B, Erden HF, Tosun S, Akbas H, Ulug U, Bahçeci M. Outcome of assisted reproduction treatment in patients with endometrial thickness less than 7 mm. Reproductive BioMedicine Online. 2009;18(1):79-84.  https://doi.org/10.1016/s1472-6483(10)60428-2
  16. Mahajan N, Sharma S. The endometrium in assisted reproductive technology: How thin is thin? Journal of Human Reproductive Sciences. 2016;9(1):3-8.  https://doi.org/10.4103/0974-1208.178632
  17. Bu Z, Sun Y. The impact of endometrial thickness on the day of human chorionic gonadotrophin (hCG) administration on ongoing pregnancy rate in patients with different ovarian response. Public Library of Science One. 2015;10(12):e0145703. https://doi.org/10.1371/journal.pone.0145703
  18. Weiss NS, van Vliet MN, Limpens J, Hompes PGA, Lambalk CB, Mochtar MH, van der Veen F, Mol BWJ, van Wely M. Endometrial thickness in women undergoing IUI with ovarian stimulation. How thick is too thin? A systematic review and meta-analysis. Human Reproduction. 2017;32(5):1009-1018. https://doi.org/10.1093/humrep/dex035
  19. Huang J, Lin J, Lu X, Gao H, Song N, Cai R, Kuang Y. Association between endometrial thickness and neonatal outcomes in intrauterine insemination cycles: a retrospective analysis of 1,016 live-born singletons. Reproductive Biology and Endocrinology. 2020; 18(1):48.  https://doi.org/10.1186/s12958-020-00597-w
  20. El-Toukhy T, Coomarasamy A, Khairy M, Sunkara K, Seed P, Khalaf Y, Braude P. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertility and Sterility. 2008;89(4):832-839.  https://doi.org/10.1016/j.fertnstert.2007.04.031
  21. Check JH, Cohen R, Wilson C, Corley D, Dietterich C. Very thin endometria in the late proliferative phase is more associated with poor pregnancy rates following controlled ovarian hyperstimulation than graduated estradiol regimens used for frozen embryo transfer. Fertility and Sterility. 2014;101:e21.  https://doi.org/10.1016/j.fertnstert.2013.11.089
  22. Dain L, Bider D, Levron J, Zinchenko V, Westler S, Dirnfeld M. Thin endometrium in donor oocyte recipients: Enigma or obstacle for implantation? Fertility and Sterility. 2013;100(5):1289-1295. https://doi.org/10.1016/j.fertnstert.2013.07.1966
  23. Gingold JA, Lee JA, Rodriguez-Purata J, Whitehouse MC, Sandler B, Grunfeld L, Mukherjee T, Copperman AB. Endometrial pattern, but not endometrial thickness, affects implantation rates in euploid embryo transfers. Fertility and Sterility. 2015;104(3):620-8.e5.  https://doi.org/10.1016/j.fertnstert.2015.05.036
  24. Zhang T, Li Z, Ren X, Huang B, Zhu G, Yang W, Jin L. Endometrial thickness as a predictor of the reproductive outcomes in fresh and frozen embryo transfer cycles. A retrospective cohort study of 1512 IVF cycles with morphologically good-quality blastocyst. Medicine. 2018;97(4):e9689. https://doi.org/10.1097/MD.0000000000009689
  25. Griesinger G, Trevisan S, Cometti B. Endometrial thickness on the day of embryo transfer is a poor predictor of IVF treatment outcome. Human Reproduction Open. 2018;2018(1):hox031. https://doi.org/10.1093/hropen/hox031
  26. Miwa I, Tamura H, Takasaki A, Yamagata Y, Shimamura K, Sugino N. Pathophysiologic features of «thin» endometrium. Fertility and Sterility. 2009;91(4):998-1004. https://doi.org/10.1016/j.fertnstert.2008.01.029
  27. Schwab KE, Gargett CE. Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium. Human Reproduction. 2007;22(11):2903-2911. https://doi.org/10.1093/humrep/dem265
  28. Gargett CE, Healy DL. Generating receptive endometrium in Asherman’s syndrome. Journal of Human Reproduction Science. 2011; 4(1):49-52. 
  29. Gargett CE, Ye L. Endometrial reconstruction from stem cells. Fertility and Sterility. 2012;98(1):11-20.  https://doi.org/10.1016/j.fertnstert.2012.05.004
  30. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertility and Sterility. 2011;95(6):2123.e13-2123.e2.123E17. https://doi.org/10.1016/j.fertnstert.2011.01.143
  31. Gleicher N, Kim A, Michaeli T, Lee HJ, Shohat-Tal A, Lazzaroni E, Barad DH. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Human Reproduction. 2013;28(1):172-177.  https://doi.org/10.1093/humrep/des370
  32. Kunicki M, Lukaszuk K, Woclawek-Potocka I, Liss J, Kulwikowska P, Szczyptanska J. Evaluation of granulocyte colony-stimulating factor effects on treatment-resistant thin endometrium in women undergoing in vitro fertilization. BioMed Research International. 2014;2014:913235. https://doi.org/10.1155/2014/913235
  33. Check JH, Cohen R, Choe JK. Failure to improve a thin endometrium in the late proliferative phase with uterine infusion of granulocyte-colony stimulating factor. Clinical and Experimental Obstetrics and Gynecology. 2014;41(4):473-475. 
  34. Barad DH, Yu Y, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, Gleicher N. A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: Impact on endometrial thickness and clinical pregnancy rates. Fertility and Sterility. 2014;101(3):710-715.  https://doi.org/10.1016/j.fertnstert.2013.12.016
  35. Obidniak D, Gzgzyan A, Dzhemlikhanova L, Feoktistov A. Effect of colony-stimulating growth factor on outcome of frozen-thawed embryo transfer in patients with repeated implantation failure. Fertility and Sterility. 2016;106(3):134-135.  https://doi.org/10.1016/j.fertnstert.2016.07.401
  36. Würfel W. Approaches to a better implantation. The Journal of Assisted Reproduction and Genetics. 2000;17:473.  https://doi.org/10.1023/A:1017399518757
  37. Aleyasin A, Abediasl Z, Nazari A, Sheikh M. Granulocyte colony-stimulating factor in repeated IVF failure, a randomized trial. Reproduction. 2016;151(6):637-642.  https://doi.org/10.1530/REP-16-0046
  38. Scarpellini F, Sbracia M. G-CSF treatment improves IVF outcome in women with recurrent implantation failure in IVF. The Journal of Reproductive Immunology. 2012;94:103. 
  39. Singh R, Singh M, Jindal A, Jindal PC. A prospective randomized controlled study (RCT) of intra-uterine administration of Granulocyte Colony-Stimulating Factor (G-CSF) before embryo-transfer on resistant thin endometrium in IVF cycles. Human Reproduction. 2015;30:i280. https://doi.org/10.1093/humrep/30.Supplement-1.1
  40. Eftekhar M, Miraj S, Mojtahedi MF, Neghab N. Efficacy of intrauterine infusion of granulocyte colony stimulating factor on patients with history of implantation failure: a randomized control trial. International Journal of Reproductive BioMedicine. 2016;14(11):687-690. 
  41. Davari-Tanha F, Tehraninejad ES, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: a randomized double blind placebo control trial. International Journal of Reproductive BioMedicine. 2016;14(12):737-742. 
  42. Zhang L, Xu WH, Fu X-H, Huang Q-X, Guo X-Y, Zhang L, Li S-S, Zhu J, Shu J. Therapeutic role of granulocyte colony-stimulating factor (G-CSF) for infertile women under in vitro fertilization and embryo transfer (IVF-ET) treatment: a meta-analysis. Archives of Gynecology and Obstetrics. 2018;298:861-871.  https://doi.org/10.1007/s00404-018-4892-4
  43. Chen MJ, Yang JH, Peng FH, Chen SU, Ho HN, Yang YS. Extended estrogen administration for women with thin endometrium in frozen-thawed in-vitro fertilization programs. The Journal of Assisted Reproduction and Genetics. 2006;23(7-8):337-342.  https://doi.org/10.1007/s10815-006-9053-1
  44. Bourdon M, Santulli P, Kefelian F, Vienet-Legue L, Maignien C, Pocate-Cheriet K, de Mouzon J, Marcellin1 L, Chapron C. Prolonged estrogen (E2) treatment prior to frozen-blastocyst transfer decreases the live birth rate. Human Reproduction. 2018;33(5):905-913.  https://doi.org/10.1093/humrep/dey041
  45. Papanikolaou EG, Kyrou D, Zervakakou G, Paggou E, Humaidan P. Follicular HCG endometrium priming for IVF patients experiencing resisting thin endometrium. A proof of concept study. The Journal of Assisted Reproduction and Genetics. 2013;30(10):1341-1345. https://doi.org/10.1007/s10815-013-0076-0
  46. Eftekhar M, Rahmani E, Eftekhar T. Effect of adding human chorionic gonadotropin to the endometrial preparation protocol in frozen embryo transfer cycles. International Journal Fertility and Sterility. 2012;6(3):175-178. 
  47. Santibañez A, García J, Pashkova O, Colín O, Castellanos G, Sánchez AP, De la Jara JF. Effect of intrauterine injection of human chorionic gonadotropin before embryo transfer on clinical pregnancy rates from in vitro fertilization cycles: a prospective study. Reproduction Biology and Endocrinology. 2014;12:9.  https://doi.org/10.1186/1477-7827-12-9
  48. Acharya S, Yasmin E, Balen AH. The use of a combination of pentoxifylline and tocopherol in women with a thin endometrium undergoing assisted conception therapies — A report of 20 cases. Human Fertility (Cambridge). 2009;12(4):198-203.  https://doi.org/10.3109/14647270903377178
  49. Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N. Endometrial growth and uterine blood flow: A pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertility and Sterility. 2010;93(6):1851-1858. https://doi.org/10.1016/j.fertnstert.2008.12.062
  50. Sher G, Fisch JD. Vaginal sildenafil (Viagra): a preliminary report of a novel method to improve uterine artery blood flow and endometrial development in patients undergoing IVF. Human Reproduction. 2000;15(4):806-809.  https://doi.org/10.1093/humrep/15.4.806
  51. Check JH, Graziano V, Lee G, Nazari A, Choe JK, Dietterich C. Neither sildenafil nor vaginal estradiol improves endometrial thickness in women with thin endometria after taking oral estradiol in graduating dosages. Clinical and Experimental Obstetrics and Gynecology. 2004;31(2):99-102. 
  52. Wang L, Huang X, Li X, Lv F, He X, Pan Y, Wang L, Zhang X. Efficacy evaluation of low-dose aspirin in IVF/ICSI patients evidence from 13 RCTs. A systematic review and meta-analysis. Medicine. 2017;96(37):e7720. https://doi.org/10.1097/MD.0000000000007720
  53. Altmäe S, Aghajanova L. Growth Hormone and Endometrial Receptivity. Frontiers in Endocrinology. 2019;10:653.  https://doi.org/10.3389/fendo.2019.00653
  54. Cui N, Li AM, Luo ZY, Zhao ZM, Xu YM, Zhang J, Yang AM, Wang LL, Hao GM, Gao BL. Effects of growth hormone on pregnancy rates of patients with thin endometrium. Journal of Endocrinological Investigation. 2019;42(1):27-35.  https://doi.org/10.1007/s40618-018-0877-1
  55. Li L, Sun X-X, Yang J-Y, Li H, Lu N. Influence of growth hormone supplementation in patients with thin endometrium undergoing frozen embryo transfer. Reproductive and Development Medicine. 2019; 3:49-53.  https://doi.org/10.4103/2096-2924.255983
  56. Wu H, Li L, Li M, Yuan H. Effect of growth hormone on the endometrial and endometrial blood flow in forzen thawed embryo tranfer. Journal of Reproductive Medicine. 2013;22:914-917. 
  57. Yu H, Gao S, Tang H, Chen H, Deng Z, Yang L, Z. Liu, Q. Tang, Ting-ting Tang. Growth hormone intrauterine perfusion combined with replacement cycle in the treatment of non-response thin endometrium: report of 5 cases. International Journal of Clinical and Experimental Medicine. 2016;9:11982-11989.
  58. Xue-Mei W, Hong J, Wen-Xiang Z, Yang L. The effects of growth hormone on clinical outcomes after frozen — thawed embryo transfer. International Journal of Gynecology and Obstetrics. 2016;133:347-350.  https://doi.org/10.1016/j.ijgo.2015.10.020
  59. Chien L-W, Au H-K, Chen P-L, Xiao J, Tzeng C-R. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertility and Sterility. 2002;78(2):245-251.  https://doi.org/10.1016/s0015-0282(02)03223-5
  60. Drago L, Bortolin M, Vassena C, Taschieri S, Del Fabbro M. Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity. BMC Microbiology. 2013;13:47.  https://doi.org/10.1186/1471-2180-13-47
  61. Mazzocca AD, McCarthy BR, Intravia J, Beitzel K, Apostolakos J, Cote MP, Bradley J, Arciero RA. An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone. Arthroscopy. 2013;29(4):675-683.  https://doi.org/10.1016/j.arthro.2012.12.005
  62. Panteleev MA, Sveshnikova AN. Platelets and hemostasis. Onkogematologiya. 2014;9(2):65-73. (In Russ.). https://doi.org/10.17650/1818-8346-2014-9-2-65-73
  63. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood. 2004;103(6):2096-104.  https://doi.org/10.1182/blood-2003-08-2804
  64. Galindo MP, Avila OG, Torrecillas ML, Fernández Barbero JE, O’Valle Ravassa F, Wang HL.Composition of platelet-rich plasma gel: A Western blot analysis. Journal Oral Science and Reabilitation. 2016;2(2):42-48. 
  65. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, Liang X. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. International Journal of Clinical and Experimental Medicine. 2015;8(1):1286-1290.
  66. Maleki-Hajiagha A, Razavi M, Rouholamin S, Rezaeinejad M, Maroufizadeh S, Sepidarkish M. Intrauterine infusion of autologous platelet-rich plasma in women undergoing assisted reproduction: A systematic review and meta-analysis. Journal of Reproductive Immunology. 2020;137:103078. https://doi.org/10.1016/j.jri.2019.103078
  67. Alves R, Grimalt R. A Review of Platelet Rich Plasma: History, Biology, Mechanism of Action, and Classification. Skin Appendage Disorders. 2018;4(1):18-24.  https://doi.org/10.1159/000477353
  68. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assisted Reproduction. 2017;21(1):54-56.  https://doi.org/10.5935/1518-0557.20170013
  69. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwan Journal Obstetrics and Gynecology. 2018; 57(6):810-813.  https://doi.org/10.1016/j.tjog.2018.10.00
  70. Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Ajori L. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Internationale Journal of Reproductive Biomedicine (Yazd). 2016;14(10):625-628.  https://doi.org/10.1016/j.tjog.2018.10.007
  71. Aghajanzadeh F, Esmaeilzadeh S, Basirat Z, Mahouti T, Heidari FN, Golsorkhtabaramiri M. Using autologous intrauterine platelet-rich plasma to improve the reproductive outcomes of women with recurrent implantation failure. JBRA Assisted Reproduction. 2020; 24(1):30-33.  https://doi.org/10.5935/1518-0557.20190055
  72. Du J, Lu H, Yu X, Dong L, Mi L, Wang J, Zheng X, Feng K. The effect of icariin for infertile women with thin endometrium: A protocol for systematic review. Medicine. 2020;99:12.  https://doi.org/10.1097/md.0000000000019111
  73. Tao Z, Liu J, Jiang Y, Gong L, Yang B. Synthesis of prenylated flavonols and their potents as estrogen receptor modulator. Science Reports. 2017;7(1):12445. https://doi.org/10.1038/s41598-017-12640-9
  74. Le AW, Shan L, Wang ZH, Dai XY, Xiaon TH, Zuo R. Effects of icariin on the expression of ER, VEGF, and KDR in the endometrial cells of thin endometrium. The Genetics and Molecular Research Journal. 2015;14(3):11250-11258. https://doi.org/10.4238/2015.September.22.19
  75. Tang Y, Jacobi A, Vater C, Zou L, Zou X, Stiehler M. Icariin promotes angiogenic differentiation and prevents oxidative stress-induced autophagy in endothelial progenitor cells. Stem Cells. 2015; 33(6):1863-1877. https://doi.org/10.1002/stem.2005
  76. Chen B, Niu SP, Wang ZY, Yin X, Han N, Kou Y, Jiang B. Local administration of icariin contributes to peripheral nerve regeneration. Neural Regeneration Research. 2005;10(20):84-89.  https://doi.org/10.4103/1673-5374.150711
  77. Qublah H, Amarin Z, Al-Quda M, Diab F, Nawasreh M, Malkawi S, Balawneh M. Luteal phase support with GnRHa improves implantation and pregnancy rates in IVF cycles with endometrium of 7 mm on day of egg retrieval. Human Fertility (Cambridge). 2008; 11(1):43-47.  https://doi.org/10.1080/14647270701704768
  78. A new non-hormonal method of treating the thin endometrium in the process of preparing patients for the in vitro fertilization program (draft newsletter). Ginekologiya. 2014;16(4): 32-33 (In Russ.).
  79. Habarov SV. Sposob lecheniya «tonkogo» endometriya. Patent na izobretenie. 2019; MPK A61N7/00, RU2709229C1. (In Russ.).
  80. Tersoglio AE, Tersoglio S, Salatino DR, Castro M, Gonzalez A, Hinojosa M, Castellano O. Regenerative therapy by endometrial mesenchymal stem cells in thin endometrium with repeated implantation failure. A novel strategy. JBRA Assisted Reproduction. 2020; 24(2):118-127.  https://doi.org/10.5935/1518-0557.20190061
  81. Motovilova TM, Kachalina TS, Zinovieva OS, Bogatova ME, Chikalova KI, Kozlova NA. The place of endometriopathy in the problem of reproductive failure and options for its correction. Meditsinskii almanakh. 2017;51(6):80-83. (In Russ.). https://doi.org/10.21145/2499-9954-2017-6-80-83
  82. Zhong Y, Zeng F, Liu W, Ma J, Guan Y, Song Y. Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis. BMC Complementary and Alternative Medicine. 2019; 19(1):61.  https://doi.org/10.1186/s12906-019-2472-1
  83. Liu KE, Hartman M, Hartman A. Management of thin endometrium in assisted reproduction: a clinical practice guideline from the Canadian Fertility and Andrology Society. Reproductive BioMedicine Online. 2019;39(1):49-62.  https://doi.org/10.1016/j.rbmo.2019.02.013

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