Diabetes mellitus and pregnancy (literature review)

Sibirskaya E.V.; Blinnikova E.S.

doi:https://doi.org/10.17116/repro202026061122

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Abstract:

Diabetes is associated with high risks of maternal and perinatal mortality, birth injuries, and long-term consequences for the mother and fetus. This article discusses the causes and mechanisms of development of pregestational and GSD, classification, comparison of diagnostic criteria and treatment tactics in different countries. The features of metabolism in pregnant women, risks for pregnant women with diabetes, as well as preconception care of patients are discussed.

Keywords:

diabetes

pregnancy

gestational diabetes mellitus

Authors:

Sibirskaya E.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;
Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health;
Pirogov Russian National Research Medical University

SPIN RSCI: 1356-9252
ORCID: 0000-0002-4540-6341

Blinnikova E.S.

Clinical hospital No. 1

Received:

14.05.2020

Accepted:

16.07.2020

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References:

Algoritmy specializirovannoj medicinskoj pomoshchi bol’nym saharnym diabetom. Pod red. Dedova I.I., Shestakovoj M.V., Majorova A.Yu. 9-j vypusk. M.: UP PRINT; 2019. (In Russ.).
Dedov II, Shestakova MV, Vikulova OK. Epidemiology of diabetes in the Russian Federation: Clinical and statistical analysis according to the Federal register of diabetes. Saharnyj diabet. 2017;20(1):13-41. (In Russ.). https://doi.org/10.14341/DM8664
International Diabetes Federation — Gestational diabetes. Accessed July 28, 2020. https://www.idf.org/our-activities/care-prevention/gdm
Agarwal MM. Gestational diabetes mellitus: An update on the current international diagnostic criteria. World Journal of Diabetes. 2015;6(6):782-791. https://doi.org/10.4239/wjd.v6.i6.782
Mackin ST, Nelson SM, Kerssens JJ, Wood R, Wild S, Colhoun HM, Leese GP, Philip S, Lindsay RS; SDRN Epidemiology Group. Diabetes and pregnancy: national trends over a 15-year period. Diabetologia. 2018;61(5):1081-1088. https://doi.org/10.1007/s00125-017-4529-3
Hod M, Kapur A, Sacks DA, Hadar E, Agarwal M, Di Renzo GC, Cabero Roura L, McIntyre HD, Morris JL, Divakar H. The International Federation of Gynecology and Obstetrics (FIGO) Initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care. International Journal of Gynaecology and Obstetrics. 2015;131(suppl 3):173-211. https://doi.org/10.1016/S0020-7292(15)30033-3
Mastrogiannis DS, Igwe E, Homko CJ. The role of telemedicine in the management of the pregnancy complicated by diabetes. Current Diabetes Reports. 2013;13(1):1-5. https://doi.org/10.1007/s11892-012-0352-x
Guariguata L, Linnenkamp U, Beagley J, Whiting DR, Cho NH. Global estimates of the prevalence of hyperglycaemia in pregnancy. Diabetes Research and Clinical Practice. 2014;103(2):176185. https://doi.org/10.1016/j.diabres.2013.11.003
American Diabetes Association. Standards of Medical Care in Diabetes — 2018. Diabetes Care. 2018;41(suppl 1):1-2. https://doi.org/10.2337/dc18-Sint01
Pincus G, White P. On the Inheritance of Diabetes Mellitus. Proceedings of the National Academy of Sciences of the United States of America. 1933;19(6):631-635. https://doi.org/10.1073/pnas.19.6.631
Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The Pathophysiology of Gestational Diabetes Mellitus. International Journal of Molecular Sciences. 2018;19(11):3342. https://doi.org/10.3390/ijms19113342
Rajput R, Vohra S, Nanda S, Rajput M. Severe 25(OH)vitamin-D deficiency: A risk factor for development of gestational diabetes mellitus. Diabetes and Metabolic Syndrome. 2019;13(2):985-987. https://doi.org/10.1016/j.dsx.2019.01.004
Kautzky-Willer A, Harreiter J, Pacini G. Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocrine Reviews. 2016;37(3):278-316. https://doi.org/10.1210/er.2015-1137
Vasileva AA. Gestational diabetes mellitus in the structure of obstetric complications of pregnancy in women after cryoprotocol in art programs. Zhurnal akusherstva i zhenskih boleznej. 2019;68(5):18. (In Russ.).
Pergialiotis V, Bellos I, Hatziagelaki E, Antsaklis A, Loutradis D, Daskalakis G. Progestogens for the prevention of preterm birth and risk of developing gestational diabetes mellitus: a meta-analysis. American Journal of Obstetrics and Gynecology. 2019;221(5):429-436.e5. https://doi.org/10.1016/j.ajog.2019.05.033
Popova PV, Gerasimov AS, Kravchuk EN, Shelepova ES, Ryazantseva EM, Tsoi UA, Zazerskaya IE, Grineva EN. The Relationship of high blood pressure in the first trimester of pregnancy and the risk of gestational diabetes. Arterial’naya gipertenziya. 2012;18(1):67-72. (In Russ.).
Zubkova NA, Burumkulova FF, Petrukhin VA, Plekhanova MA, Panov AE, Vasiliev EV, Petrov VM, Makretskaya NA, Tulpakov AN. Mutations in the genes of nuclear factors of hepatocytes as a rare cause of diabetes in pregnant women. Saharnyj diabet. 2019;22(3): 274-280. (In Russ.). https://doi.org/10.14341/DM9945
Kleinberger JW, Pollin TI. Undiagnosed MODY: Time for Action. Current Diabetes Reports. 2015;15(12):110. https://doi.org/10.1007/s11892-015-0681-7
Schaefer-Graf U, Napoli A, Nolan CJ; Diabetic Pregnancy Study Group. Diabetes in pregnancy: a new decade of challenges ahead. Diabetologia. 2018;61(5):1012-1021. https://doi.org/10.1007/s00125-018-4545-y
Jones LV, Ray A, Moy F, Buckley BS. Techniques of monitoring blood glucose during pregnancy for women with pre-existing diabetes. The Cochrane Database of Systematic Reviews. 2019;5CD009613. https://doi.org/10.1002/14651858.CD009613.pub4
Shpakov AO. The Role of disorders in hormonal signaling systems in the etiology and pathogenesis of diabetes mellitus. Zhurnal evolyucionnoj biohimii i fiziologii. 2014;50(6):482-486. (In Russ.).
Shpakov AO, Derkach KV. Adenylate Cyclase system in the liver and pancreas in normal and diabetic pathology. Rossijskij fiziologicheskij zhurnal im. I.M. Sechenova. 2016;102(9):1030-1050. (In Russ.).
Petruhin VV. Saharnyj diabet i beremennost’. Accessed July 28, 2020. (In Russ.). https://present5.com/saxarnyj-diabet-i-beremennost-v-a-petruxin-d/
Kapustin RV, Arzhanova ON, Tselko AV. Oxidative stress in pregnant women with diabetes. Saharnyj diabet. 2017;20(6):461-471. (In Russ.). https://doi.org/10.14341/DM8669
Berger H, Gagnon R, Sermer M, Basso M, Bos H, Brown RN, Bujold E, Cooper SL, Gagnon R, Gouin K, McLeod NL, Menticoglou SM, Mundle WR, Roggensack A, Sanderson FL, Walsh JD. Diabetes in Pregnancy. Journal of Obstetrics and Gynaecology Canada: JOGC. 2016;38(7):667-679. https://doi.org/10.1016/j.jogc.2016.04.002
McCance DR. Diabetes in pregnancy. Best Practice and Research. Clinical Obstetrics and Gynaecology. 2015;29(5):685-699. https://doi.org/10.1016/j.bpobgyn.2015.04.009
Egan AM, Hod M, Mahmood T, Dunne FP. Perspectives on diagnostic strategies for hyperglycaemia in pregnancy — dealing with the barriers and challenges: Europe. Diabetes Research and Clinical Practice. 2018;145:67-72. https://doi.org/10.1016/j.diabres.2018.06.001
Huhn EA, Rossi SW, Hoesli I, Göbl CS. Controversies in Screening and Diagnostic Criteria for Gestational Diabetes in Early and Late Pregnancy. Frontiers in Endocrinology. 2018;9:696. https://doi.org/10.3389/fendo.2018.00696
Gestacionnyj saharnyj diabet. Diagnostika, lechenie, poslerodovoe nablyudenie. Klinicheskie rekomendacii. Accessed July 20, 2020. https://mosgorzdrav.ru/uploads/imperavi/ru-RU/014_2014.pdf
Savvidou M, Syngelaki A, Muhaisen M, Emelyanenko E, Nicolaides K. First trimester maternal serum free β-human chorionic gonadotropin and pregnancy-associated plasma protein A in pregnancies complicated by diabetes mellitus. BJOG: An International Journal of Obstetrics and Gynaecology. 2012;119(4):410416. https://doi.org/10.1111/j.1471-0528.2011.03253.x
Krasnopolsky VI, Petrukhin VA, Chechneva MA, Lysenko SN, Ermakova LB. Antenatal ultrasound diagnostics of diabetic fetopathy and macrosomia. Arhiv akusherstva i ginekologii im. V.F. Snegireva. 2014;1(1):51-53. (In Russ.).
Burumkulova FF. Gestacionnyj saharnyj diabet (endokrinologicheskie, akusherskie i perinatal’nye aspekty): Dis. ... d-ra med. nauk. M. 2011. (In Russ.).
Lysenko SN, Chechneva MA, Petrukhin VA, Aksenov AN, Ermakova LB. Possibilities of determining fetal maturity in ultrasound diagnostics. Al’manah klinicheskoj mediciny. 2015;37:41-46. (In Russ.).
Lebedeva MA, Gagaev ChG. Diameter of the fetal umbilical cord in normal pregnancy and pregnancy complicated by diabetes mellitus. Trudnyj pacient. 2019;17(1-2):25-27. (In Russ.). https://doi.org/10.24411/2074-1995--2019-10004
Lysenko SN, Petrukhin VA, Chechneva MA, Burumkulova FF, Ermakova LB. Fetal pancreas in the normal and complicated course of pregnancy with diabetes mellitus. Vrach. 2013;8:62-64. (In Russ.).
Lysenko SN, Burumkulova FF, Chechneva MA, Petrukhin VA, Gurieva VM, Panov AE, Yablokova ME. Clinical significance of assessment of hemodynamics in the fetal umbilical artery for the diagnosis of diabetic fetopathy. Lechenie i profiaktika. 2018;8(2):5-8. (In Russ.).
Sibirskaya EV, Adamyan LV, Koltunov IE, Petryaikina EE, Smal TA. Menstrual function of girls with type 1 diabetes. Problemy reprodukcii. 2015;21(3)84-88. (In Russ.).
Gurieva VM, Burumkulova FF, Budykina TS, Morokhotova LS, Buyvalo TA. Pregnancy complications in women with diabetes and the possibility of their correction. Al’manah klinicheskoj mediciny. 2015;37:32-31. (In Russ.).
Sibirskaya EV, Koltunov IE, Petryaikina EE, Smal TA, Shutkova AYu. The Role of antiovarial antibodies in the pathogenesis of menstrual cycle disorders in girls and girls with type 1 diabetes. Problemy reprodukcii. 2015;21(6):85-89. (In Russ.).
Su Y, Wu J, He J, Liu X, Chen X, Ding Y, Zhang C, Chen W, Wang Y, Gao R. High insulin impaired ovarian function in early pregnant mice and the role of autophagy in this process. Endocrine Journal. 2017;64(6):613-621. https://doi.org/10.1507/endocrj.EJ16-0494
Kamalakannan D, Baskar V, Barton DM, Abdu TA. Diabetic ketoacidosis in pregnancy. Postgraduate Medical Journal. 2003;79(934): 454-457. https://doi.org/10.1136/pmj.79.934.454
Yablokova ME, Gur’eva VM, Shojbonov BB. Nekotorye aspekty patogeneza gipertenzivnyh oslozhnenij u beremennyh s razlichnymi tipami saharnogo diabeta. Saharnyj diabet — pandemiya XXI veka. Sbornik tezisov VIII (XXV) Vserossijskogo diabetologicheskogo kongressa s mezhdunarodnym uchastiem. FGBU «NMIC endokrinologii» Minzrava Rossii; OO «Rossijskaya associaciya endokrinologov»; 2018;557-558. (In Russ.).
Kovalev VV, Putilova TA, Tretyakova TB, Deryabina EG. Association of polymorphisms of blood pressure regulating genes with hypertensive pregnancy complications in patients with gestational diabetes mellitus. Akusherstvo i ginekologiya. 2013;3:58-62. (In Russ.).
Zisser HC, Biersmith MA, Jovanovič LB, Yogev Y, Hod M, Kovatchev BP. Fetal risk assessment in pregnancies complicated by diabetes mellitus. Journal of Diabetes Science and Technology. 2010; 4(6):1368-1373. https://doi.org/10.1177/193229681000400610
O’Neill SM, Kenny LC, Khashan AS, West HM, Smyth RMD, Kearney PM. Different insulin types and regimens for pregnant women with pre-existing diabetes. The Cochrane Database of Systematic Reviews. 2017;2(2):CD011880. https://doi.org/10.1002/14651858.CD011880.pub2
Tiselco AV. Risk Factors for development of abnormal glucose variability in pregnant women with diabetes mellitus of the first type. Zhurnal akusherstva i zhenskih boleznej. 2019;68(3):41-50. (In Russ.). https://doi. org/10.17816/JOWD68341-50
Pankratova OA, Rimashevsky VV. Analysis of the condition of newborn children depending on the method of insulin administration in pregnant women with type 1 diabetes. Reproduktivnoe zdorov’e. Vostochnaya Evropa. 2012;5(23):542-544. (In Russ.).
Kazimova AU, Huseynova GA, Abdullayeva RM. Phytotherapy of pregnancy diabetes. Problemy sovremennoj nauki i obrazovaniya. 2018;8(128):89-95. (In Russ.).
Shikh EV, Grebenshchikova LYu. Correction of vitamin and mineral status in pregnant women with a high risk of fetal macrosom. Voprosy ginekologii, akusherstva i perinatologii. 2013;12(4):17-23. (In Russ.).
Dodd JM, Grivell RM, Deussen AR, Hague WM. Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes. The Cochrane Database of Systematic Reviews. 7(7):CD010564. https://doi.org/10.1002/14651858.CD010564.pub2
Sazonova AI, Esayan RM, Kolegaeva OI, Gardanova ZhR. Effectiveness and safety of Metformin in pregnancy for the treatment of gestational diabetes mellitus: a modern view of the problem. Saharnyj diabet. 2016;19(2):164-170. (In Russ.). https://doi.org/10.14341/DM2004126-29
Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. American Journal of Obstetrics and Gynecology. 2017;216(2):110-120.e116. https://doi.org/10.1016/j.ajog.2016.09.076