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Kononova I.N.

Interregional Center for Continuing Professional Education

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Bebneva T.N.

Medical Institute of the Russian State University of People;
National Medical Research Center of Endocrinology of the Ministry of Health of Russia

Kareva E.N.

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;
First Moscow State Medical University of the Ministry of Health of the Russian Federation

A Shmakova N.

Ural Research Institute of Motherhood and Infancy

The value of local antiviral therapy for HPV-associated grade I cervical intraepithelial neoplasias during pregnancy

Authors:

Kononova I.N., Dobrokhotova Yu.E., Bebneva T.N., Kareva E.N., A Shmakova N.

More about the authors

Journal: Russian Journal of Human Reproduction. 2020;26(6): 108‑113

DOI: 10.17116/repro202026061108

Views: 515

Downloaded: 5

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Table of contents

THE VALUE OF LOCAL ANTIVIRAL THERAPY FOR HPV-ASSOCIATED GRADE I CERVICAL INTRAEPITHELIAL NEOPLASIAS DURING PREGNANCY
THE VALUE OF LOCAL ANTIVIRAL THERAPY FOR HPV-ASSOCIATED GRADE I CERVICAL INTRAEPITHELIAL NEOPLASIAS DURING PREGNANCY

To cite this article:

Kononova IN, Dobrokhotova YuE, Bebneva TN, Kareva EN, A Shmakova N. The value of local antiviral therapy for HPV-associated grade I cervical intraepithelial neoplasias during pregnancy. Russian Journal of Human Reproduction. 2020;26(6):108‑113. (In Russ.)
https://doi.org/10.17116/repro202026061108

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
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BACKGRAUND

The high incidence of CIN I during pregnancy (25-32%), contributing to the development of complications of the gestational period, having a negative impact on the development of the fetus and newborn, has actualized the search for new safe methods of treating CIN I to prevent complications of the gestational period and improve perinatal outcomes.

OBJECTIVE

To study the clinical efficacy of the antiviral drug PANAVIR in the treatment of HPV-associated grade I cervical intraepithelial neoplasias during pregnancy.

MATERIAL AND METHODS

A comparative analysis of the results of treatment of 50 pregnant women with HPV-associated CIN I was carried out. The 1st group included 25 patients who received Panavir 1 suppository once a day No. 10 intravaginally, 25 pregnant women of the 2nd group were not prescribed CIN I treatment according to the Protocol.

RESULTS

It was found that in 82% of patients with CIN I pregnancy was accompanied by maladjustment of the vaginal ecosystem with the active participation of anaerobic microflora. The inclusion of Panavir in the treatment of CIN I promotes the elimination of the human papillomavirus in 68% of pregnant women, the transition of CIN I to the metaplasia stage with acceleration of reparative processes on the cervix in 80% of cases, the prevention of obstetric pathology and perinatal outcomes.

CONCLUSIONS

The results obtained allow Panavir to be recommended for the treatment of HPV-associated CIN I in pregnancy to improve perinatal outcomes.

Keywords:

HPV
cervical intraepithelial neoplasia
pregnancy
Panavir

Authors:

Kononova I.N.

Interregional Center for Continuing Professional Education

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Bebneva T.N.

Medical Institute of the Russian State University of People;
National Medical Research Center of Endocrinology of the Ministry of Health of Russia

Kareva E.N.

Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation;
First Moscow State Medical University of the Ministry of Health of the Russian Federation

A Shmakova N.

Ural Research Institute of Motherhood and Infancy

Received:

29.08.2020

Accepted:

11.10.2020

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