INTRODUCTION

Chronic endometritis, which occupies a leading place in the structure of chronic inflammatory diseases of the pelvic organs in women, significantly reduces the effectiveness of assisted reproductive technologies (ART) programs. It is known that a violation of the local immune response of the endometrium, plays an important role in the pathogenesis of this disease.

PURPOSE

The aim of this study was to explore the effectiveness of ART programs (cryoprotocols) in women with chronic endometritis after normalization of the local expression of innate immunity factors in the endometrium. For this purpose, the drug superlimph was used, which is a complex of natural stimulants of the immune system.

MATERIAL AND METHODS

The study included 83 women under the age of 38 years with infertility, chronic endometritis and unsuccessful attempts at IVF with embryo transfer in history. According to the treatment, two groups of patients were identified: group 1 consisted of 45 women, who used superlimph 25 IU daily — 1 suppository per rectum or per vaginae for 20 days from the second day in the previous of the cryotransfer cycle. Group 2 included 38 women who used superlimph 25 IU daily, 1 suppository per rectum or per vaginae for 10 days from the 5th day of the menstrual cycle directly in the cryotransfer protocol. All women underwent a cryoprotocol with hormone replacement therapy. The diagnosis of chronic endometritis was histologically confirmed.

RESULTS

It was found, that pregnancy was twice as likely to occur in group 2 (44.7%) as compared to group 1 (17.7%).

CONCLUSIONS

Normalization of local expression endometrium innate immunity factors in the women with chronic endometritis directly in the embryo transfer cycle, seems to be a very promising stage of pregravid preparation in ART protocols.