
Revision breast reconstruction with autologous tissue following failed immediate implant-based reconstruction
Журнал: Пластическая хирургия и эстетическая медицина. 2026;(3):16-25.
DOI: 10.17116/plast.hirurgia202603116
Read: 384 раза
Abstract
OBJECTIVE
To analyze the outcomes of redo breast reconstruction using autologous flaps in patients with unsatisfactory results after previous implant-based reconstruction.
MATERIAL AND METHODS
Between September 2020 and March 2025, we retrospectively analyzed 40 patients who underwent redo breast reconstruction with autologous flaps. All patients were divided into two groups: group 1 (n=19) — previous implant-based reconstruction and subsequent redo reconstruction with thoracodorsal (latissimus dorsi) flap; group 2 (n=21) — obese patients with excess subcutaneous fat in the lower abdominal region and large contralateral breast after primary implant-based reconstruction and clear indications for redo reconstruction using a DIEP flap.
RESULTS. M
Ean follow-up period was 37±1.8 months (range 3—57), age of patients — 49.3±7.8 years, body mass index — 26.1±3.4 kg/m². Comorbidities were observed in 37.5% (n=15) of patients. Mean duration of redo reconstruction with autologous tissue was 7.9±1.1 hours, mean hospital-stay — 7.1±2.6 days. No flap loss was observed after redo reconstruction. Mean satisfaction score after autologous flap grafting was 85.2±3.2 (high patient satisfaction).
CONCLUSION
Autologous breast reconstruction is effective after previous implant-based reconstruction with unsatisfactory outcomes. Modern strategies in this field are aimed at reducing donor site morbidity, optimizing recipient vessel preparation, shortening rehabilitation and achieving the most natural aesthetic results.
Keywords
- thoracodorsal flap
- DIEP flap
- radiotherapy
- breast cancer
- immediate breast reconstruction
Дата поступления: 06.06.2025
Дата принятия в печать: 24.08.2025
Дата публикации: 21.09.2026
- Kim J, Harper A, McCormack V, Sung H, Houssami N, Morgan E, Mutebi M, Garvey G, Soerjomataram I, Fidler-Benaoudia MM. Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nature Medicine. 2025 Apr;31(4):1154-1162. Epub 2025 Feb 24. PMID: 39994475. https://doi.org/10.1038/s41591-025-03502-3
- Harcourt D, Rumsey N. Psychological aspects of breast reconstruction: a review of the literature. J Adv Nurs. 2001 Aug;35(4):477-487. PMID: 11529946. https://doi.org/10.1046/j.1365-2648.2001.01865.x
- Xu Y, Gong M, Wang Y, Yang Y, Liu S, Zeng Q. Global Trends and Forecasts of Breast Cancer Incidence and Deaths. Scientific Data. 2023;10(1):334. https://doi.org/10.1038/s41597-023-02253-5
- Golubeva TS, Todua NG, Belova EV. Epidemiology and diagnosis of breast cancer at the present stage (literature review). Universum: Medicine and Pharmacology. 2025;1(118). (In Russ.). Accessed May 02, 2025. https://7universum.com/ru/med/archive/item/19071
- Ginsburg O, Yip CH, Brooks A, Cabanes A, Caleffi M, Dunstan Yataco JA, Gyawali B, McCormack V, McLaughlin de Anderson M, Mehrotra R, Mohar A, Murillo R, Pace LE, Paskett ED, Romanoff A, Rositch AF, Scheel JR, Schneidman M, Unger-Saldaña K, Vanderpuye V, Wu TY, Yuma S, Dvaladze A, Duggan C, Anderson BO. Breast cancer early detection: A phased approach to implementation. Cancer. 2020 May 15;126(Suppl 10):2379-2393. PMID: 32348566; PMCID: PMC7237065. https://doi.org/10.1002/cncr.32887
- Duggan C, Dvaladze A, Rositch AF, Ginsburg O, Yip CH, Horton S, Camacho Rodriguez R, Eniu A, Mutebi M, Bourque JM, Masood S, Unger-Saldaña K, Cabanes A, Carlson RW, Gralow JR, Anderson BO. The Breast Health Global Initiative 2018 Global Summit on Improving Breast Healthcare Through Resource-Stratified Phased Implementation: Methods and overview. Cancer. 2020 May 15;126(Suppl 10):2339-2352. PMID: 32348573; PMCID: PMC7482869. https://doi.org/10.1002/cncr.32891
- Ryu H, Shin KH, Chang JH, Jang BS. A nationwide study of breast reconstruction after mastectomy in patients with breast cancer receiving postmastectomy radiotherapy: comparison of complications according to radiotherapy fractionation and reconstruction procedures. British Journal of Cancer. 2024 July;131(2):290-298. Epub 2024 June 05. PMID: 38840031; PMCID: PMC11263609. https://doi.org/10.1038/s41416-024-02741-4
- Ghazal ID, Eleweke C, Aladesanwa FO, Onabajo BO. Post-Mastectomy Breast Reconstruction: An Overview of the State of the Art, Challenges, and Prospects. International Surgery Journal. 2023;10(2):348-354. https://doi.org/10.18203/2349-2902.isj20230283
- Hong SE, Kang D. Navigating the Pandemic: Shifts in Breast Reconstruction Trends and Surgical Decision-Making in the United States. Journal of Clinical Medicine. 2024;13(14):4168. https://doi.org/10.3390/jcm13144168
- Liu D. New plastic surgery statistics and breast reconstruction trends. American Society of Plastic Surgeons. Accessed May 02, 2025. https://www.plasticsurgery.org/news/blog/new-plastic-surgery-statistics-and-breast-reconstruction-trends?utm_source=chatgpt.com
- Galimberti V, Vicini E, Corso G, Morigi C, Fontana S, Sacchini V, Veronesi P. Nipple-sparing and skin-sparing mastectomy: Review of aims, oncological safety and contraindications. Breast. 2017 Aug;34(Suppl 1):S82-S84. Epub 2017 June 30. PMID: 28673535; PMCID: PMC5837802. https://doi.org/10.1016/j.breast.2017.06.034
- van Verschuer VM, Maijers MC, van Deurzen CH, Koppert LB. Oncological safety of prophylactic breast surgery: skin-sparing and nipple-sparing versus total mastectomy. Gland Surg. 2015 Dec;4(6):467-475. PMID: 26645001; PMCID: PMC4647001. https://doi.org/10.3978/j.issn.2227-684X.2015.02.01
- Matar DY, Wu M, Haug V, Orgill DP, Panayi AC. Surgical complications in immediate and delayed breast reconstruction: A systematic review and meta-analysis. Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 2022 Nov;75(11):4085-4095. Epub 2022 Aug 22. PMID: 36202732. https://doi.org/10.1016/j.bjps.2022.08.029
- Elmore LC, Dietz JR, Myckatyn TM, Margenthaler JA. The Landmark Series: Mastectomy Trials (Skin-Sparing and Nipple-Sparing and Reconstruction Landmark Trials). Annals of Surgical Oncology. 2021 Jan;28(1):273-280. Epub 2020 Sep 4. PMID: 32886286. https://doi.org/10.1245/s10434-020-09052-x
- Johnson L, White P, Jeevan R, Browne J, Gulliver-Clarke C, O’Donoghue J, Mohiuddin S, Hollingworth W, Fairbrother P, MacKenzie M, Holcombe C, Potter S. Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: population-based cohort study. Br J Surg. 2023 Nov 09;110(12):1815-1823. PMID: 37766501; PMCID: PMC10638530. https://doi.org/10.1093/bjs/znad276
- Park S-H, Han W, Yoo T-K, Lee H-B, Jin US, Chang H, Minn KW, Noh D-Y. Oncologic Safety of Immediate Breast Reconstruction for Invasive Breast Cancer Patients: A Matched Case Control Study. J Breast Cancer. 2016 Mar;19(1):68-75. Epub 2016 Mar 25. PMID: 27064557; PMCID: PMC4822109. https://doi.org/10.4048/jbc.2016.19.1.68
- Barry M, Kell MR. Radiotherapy and breast reconstruction: a meta-analysis. Breast Cancer Res Treat. 2011 May;127(1):15-22. Epub 2011 Feb 20. PMID: 21336948. https://doi.org/10.1007/s10549-011-1401-x
- Zikiryahodzhaev AD, Shirokikh IM, Ablitsova NV, Ermoshenkova MV, Khakimova ShG, Khakimova GG, Tukmakov AYu. Effect of radiation therapy on breast immediate reconstruction in breast cancer patients. Voprosy onkologii. 2019;65(3):374-385. (In Russ.).
- Sekiguchi K, Kawamori J, Yamauchi H. Breast Reconstruction and Postmastectomy Radiotherapy: Complications by Type and Timing and Other Problems in Radiation Oncology. Breast Cancer. 2017;24 (4):511-520. https://doi.org/10.1007/s12282-017-0754-3
- Vinsensia M, Schaub R, Meixner E, Hoegen P, Arians N, Forster T, Hoeltgen L, Köhler C, Uzun-Lang K, Batista V, König L, Zivanovic O, Hennigs A, Golatta M, Heil J, Debus J, Hörner-Rieber J. Incidence and Risk Assessment of Capsular Contracture in Breast Cancer Patients following Post-Mastectomy Radiotherapy and Implant-Based Reconstruction. Cancers (Basel). 2024 Jan 07;16(2):265. PMID: 38254756; PMCID: PMC10813520. https://doi.org/10.3390/cancers16020265
- Kazaryan SG, Startseva OI, Ermoshenkova MV. Repeat surgeries using anterior abdominal wall flaps after single-stage breast reconstruction (literature review). Issues of Reconstructive and Plastic Surgery. 2024;27(3):30-39. (In Russ.). https://doi.org/10.52581/1814-1471/90/03
- Terao Y, Taniguchi K, Fujii M, Moriyama S. Postmastectomy radiation therapy and breast reconstruction with autologous tissue. Breast Cancer. 2017 July;24(4):505-510. Epub 2017 Feb 22. PMID: 28229358. https://doi.org/10.1007/s12282-017-0760-5
- Ostapenko E. The Impact of Adjuvant Radiotherapy on Immediate Prepectoral Implant-Based Breast Reconstruction. European Journal of Cancer. 2024;200:113961. https://doi.org/10.1016/j.ejca.2024.113961
- Mishra A, Kapoor R, Sharma DN, Saini SK. Implant-Based Immediate Breast Reconstruction and Adjuvant Radiotherapy. Journal of Cancer Research and Therapeutics. 2024;20(6):1669-1670. https://doi.org/10.4103/jcrt.jcrt_1627_24
- Zugasti A, Hontanilla B. The Impact of Adjuvant Radiotherapy on Immediate Implant-Based Breast Reconstruction Surgical and Satisfaction Outcomes: A Systematic Review and Meta-Analysis. Plastic and Reconstructive Surgery — Global Open. 2021;9(11):e3910. https://doi.org/10.1097/gox.0000000000003910
- Duadze IS, Zikiryakhodzhaev AD, Sukhotko AS, Starkova MV, Usov FN, Bagdasarova DV, Dzhabrailova DSh, Khakimova ShG. Breast reconstruction with deep inferior epigastric artery perforator flap (DIEP-flap). History of development. Research’n Practical Medicine Journal. 2021;8(3):108-117. (In Russ.). https://doi.org/10.17709/2410-1893-2021-8-3-10
- Sinnott CJ, Persing SM, Pronovost M, Hodyl C, McConnell D, Ott Young A. Impact of Postmastectomy Radiation Therapy in Prepectoral Versus Subpectoral Implant-Based Breast Reconstruction. Ann Surg Oncol. 2018 Oct;25(10):2899-2908. Epub 2018 July 05. PMID: 29978367. https://doi.org/10.1245/s10434-018-6602-7
- Johnson L, White P, Jeevan R, Browne J, Gulliver-Clarke C, O’Donoghue J, Mohiuddin S, Hollingworth W, Fairbrother P, MacKenzie M, Holcombe C, Potter S. Long-term patient-reported outcomes of immediate breast reconstruction after mastectomy for breast cancer: population-based cohort study. Br J Surg. 2023 Nov 09;110(12):1815-1823. PMID: 37766501; PMCID: PMC10638530. https://doi.org/10.1093/bjs/znad276
- Lee C-C, Perng C-K, Ma H, Wu S-H, Hsiao F-Y, Tseng L-M, Tsai Y-F, Lin Y-S, Lien P-J, Feng C-J. Long-Term Complications and Patient-Reported Outcomes After Alloplastic Breast Reconstruction. Annals of Plastic Surgery. 2022 Mar 01;88(1s Suppl 1):S78-S84. PMID: 35225852. https://doi.org/10.1097/sap.0000000000003114
- Escandón JM, Escandón L, Ahmed A, Weiss A, Nazerali R, Ciudad P, Langstein HN, Manrique OJ. Breast Reconstruction Using the Latissimus Dorsi Flap and Immediate Fat Transfer (LIFT): A Systematic Review and Meta-Analysis. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2022; 75(11):4106-4116. https://doi.org/10.1016/j.bjps.2022.08.025
- Panchal H, Matros E. Current Trends in Postmastectomy Breast Reconstruction. Plastic and Reconstructive Surgery. 2017 Nov;140(5S Advances in Breast Reconstruction):7S-13S. PMID: 29064917; PMCID: PMC5722225.. https://doi.org/10.1097/PRS.0000000000003941
- Hamdi M, Andrades P, Thiessen F, Stillaert F, Roche N, Van Landuyt K, Monstrey S. Is a second free flap still an option in a failed free flap breast reconstruction? Plast Reconstr Surg. 2010 Aug;126(2):375-384. PMID: 20679823. https://doi.org/10.1097/PRS.0b013e3181de22f3
- Namnoum JD. Commentary on: Patient-Reported Outcomes of Aesthetics and Satisfaction in Immediate Breast Reconstruction After Nipple-Sparing Mastectomy With Implants and Fat Grafting. Aesthet Surg J. 2017 Oct 01; 37(9):1009-1011. PMID: 29025228. https://doi.org/10.1093/asj/sjx083
- Demiri EC, Dionyssiou DD, Tsimponis A, Goula C-O, Pavlidis LC, Spyropoulou G-A. Outcomes of Fat-Augmented Latissimus Dorsi (FALD) Flap versus Implant-Based Latissimus Dorsi Flap for Delayed Post-Radiation Breast Reconstruction. Aesthetic Plastic Surgery. 2018;42(3):692-701. https://doi.org/10.1007/s00266-018-1081-6
- Laporta R, Sorotos M, Longo B, Santanelli di Pompeo F. Tips and Tricks to Improve Clinical and Aesthetic Outcomes in Latissimus Dorsi Flap Breast Reconstruction. J Reconstr Microsurg. 2017 Sept;33(7):455-465. Epub 2017 Apr 03. PMID: 28371964. https://doi.org/10.1055/s-0037-1601379
- Shah HR, Deshpande A, Bipte S. Simultaneous, Immediate and Delayed Breast Reconstruction. Indian Journal of Surgery. 2023;86(1):191-194. https://doi.org/10.1007/s12262-023-03822-z
- Rautalin M, Jahkola T, Roine RP. Breast Reconstruction-Prospective Follow up on Breast Cancer Patients’ Health-Related Quality of Life. World Journal of Surgery. 2022 Apr;46(4):836-844. Epub 2022 Jan 09. PMID: 35001140; PMCID: PMC8885544. https://doi.org/10.1007/s00268-021-06426-4
- Musmann RJ, Andree C, Munder B, Hagouan M, Janku D, Daniels M, Aufmesser-Freyhardt B, Becker K, Oramary A, Bromba A, Stockhausen N, Wolter A, Fertsch S. Secondary solution for breast reconstruction following total DIEP flap loss: A single-center experience after 3270 DIEP flaps. Journal of Plastic Reconstructive & Aesthetic Surgery. 2024 May;92:11-25. Epub 2024 Feb 28. PMID: 38489983. https://doi.org/10.1016/j.bjps.2024.02.059
- Ali SR, Holmes WJM, Quinn M, Emam AT, Prousskaia E, Wilson SM. Tertiary Breast Reconstruction for Salvage of the Failed Implant-Based Reconstruction Using the Deep Inferior Epigastric Perforator Flap. Journal of Reconstructive Microsurgery. 2018 Nov;34(9):e1-e2. Epub 2019 Feb 21. PMID: 30791061. https://doi.org/10.1055/s-0039-1679885
- Chawla A, Kachnic LA, Taghian AG, Niemierko A, Zapton DT, Powell SN. Radiotherapy and Breast Reconstruction: Complications and Cosmesis with TRAM versus Tissue Expander/Implant. International Journal of Radiation Oncology Biology Physics. 2002;54(2):520-526. https://doi.org/10.1016/s0360-3016(02)02951-6
Recommended articles:
Modern surgical approaches to prevention of upper limb lymphedema after treatment of breast cancer.Plastic Surgery and Aesthetic Medicine. 2026;(3):43-49
Evolution of integrated morphological prognostic indices in breast cancer diagnosis. Total malignancy score and nottingham prognostic index.Russian Journal of Archive of Pathology. 2026;88(3):92-97
Prescription of menopausal hormone therapy during and after completion of treatment for malignant tumors of the woman’s reproductive system: a systematic review of current clinical guidelines.P.A. Herzen Journal of Oncology. 2026;15(3):99-111
Routing in breast cancer as a factor in timely provision of medical care.P.A. Herzen Journal of Oncology. 2026;15(3):62-67
The use of botulinum toxin type A in the conservative treatment of capsular contracture grades II—III according to Baker.P.A. Herzen Journal of Oncology. 2026;15(3):50-55
Strategies to overcome endocrine resistance in HR+/HER2- metastatic breast cancer: a real-world data.P.A. Herzen Journal of Oncology. 2026;15(3):34-42
Day-case surgery for breast cancer. Myth or reality?Pirogov Russian Journal of Surgery. 2026;(5):67-74
Pharmacoeconomic analysis of the use of capivasertib plus fulvestrant versus alpelisib plus fulvestrant for patients with locally advanced or metastatic HR-positive, HER2-negative breast cancer in the Russian Federation.P.A. Herzen Journal of Oncology. 2026;15(2):51-58
The role of nutritional components in the breast cancer prevention and treatment.Russian Journal of Preventive Medicine. 2026;29(4):76-82
Incidence of regional lymph node metastases in patients with early prognostically unfavorable molecular biological breast cancer.Pirogov Russian Journal of Surgery. 2025;(7):11-15


