Proton beam therapy and photodynamic therapy in organ-preserving treatment of uveal melanoma

Panova I.E.

S. Fyodorov Eye Microsurgery Federal State Institution the St. Petersburg Branch;
St. Petersburg State University

ORCID: 0000-0001-7443-4555

Vorobyov N.A.

St. Petersburg State University;
Medical and Diagnostic Center of International Institute of Biological Systems named after Berezin Sergei

ORCID: 0000-0002-6998-5771

Samkovich E.V.

S. Fyodorov Eye Microsurgery Federal State Institution the St. Petersburg Branch

ORCID: 0000-0002-5573-5712

Svistunova E.M.

S. Fyodorov Eye Microsurgery Federal State Institution the St. Petersburg Branch

ORCID: 0009-0000-2126-4345

Proton beam therapy and photodynamic therapy in organ-preserving treatment of uveal melanoma

Authors:

Panova I.E., Vorobyov N.A., Samkovich E.V., Svistunova E.M.

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Journal: P.A. Herzen Journal of Oncology. 2024;13(4): 59‑65

DOI: 10.17116/onkolog20241304159

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To cite this article:

Panova IE, Vorobyov NA, Samkovich EV, Svistunova EM. Proton beam therapy and photodynamic therapy in organ-preserving treatment of uveal melanoma. P.A. Herzen Journal of Oncology. 2024;13(4):59‑65. (In Russ.)
https://doi.org/10.17116/onkolog20241304159

Подписка 2025 (P.A. Herzen Journal of Oncology)

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The article is devoted to the issue of organ-preserving combined treatment of large uveal melanoma (UM) with locally advanced lesions using proton beam therapy (PT) and photodynamic therapy (PDT). In this clinical case study, the technologies of PT using a pencil beam scanning and PDT in hybrid mode are considered. Preliminary results of application of the above-mentioned methods in combined organ-preserving treatment of UM are very encouraging, they allow to preserve the eyeball not only cosmetically, but also functionally, even at locally advanced stages of the process, thus providing social adaptation of patients. It seems promising to further study the possibilities of photodynamic therapy as a potentiating method of treatment to accelerate the rate of tumor regression due to direct cytotoxic action, as well as indirect effects in the form of thrombosis of feeding intratumoral vessels and activation of immune response.

Keywords:

choroid melanoma

proton beam therapy

photodynamic therapy

uveal melanoma

ophthalmo-oncology

choroid melanoma treatment

Authors:

Panova I.E.

S. Fyodorov Eye Microsurgery Federal State Institution the St. Petersburg Branch;
St. Petersburg State University

ORCID: 0000-0001-7443-4555

Vorobyov N.A.

St. Petersburg State University;
Medical and Diagnostic Center of International Institute of Biological Systems named after Berezin Sergei

ORCID: 0000-0002-6998-5771

Samkovich E.V.

S. Fyodorov Eye Microsurgery Federal State Institution the St. Petersburg Branch

ORCID: 0000-0002-5573-5712

Svistunova E.M.

S. Fyodorov Eye Microsurgery Federal State Institution the St. Petersburg Branch

ORCID: 0009-0000-2126-4345

Received:

03.08.2023

Accepted:

03.11.2023

List of references:

Grishina EE, Lerner MYu, Gemdzhyan EG. Epidemiology of uveal melanomas in Moscow. Almanac of Clinical Medicine. 2007;45(4):321-325. (In Russ.). https://doi.org/10.18786/2072-0505-2017-45-4-321-325
Brovkina AF, ed. Ophtalmooncology. Manual for physicians. Moscow: Meditsina; 2002;424. (In Russian).
Brovkina AF. Current aspects of treatment for choroidal melanomas: problems, controversial questions. Vestnik Oftal’mologii. 2006;122(1):13-16. (In Russ.).
Kujala E, Mäkitie T, Kivelä T. Very long-term prognosis of patients with malignant uveal melanoma. Invest Ophthalmol Vis Sci. 2003;44(11):4651-4659. https://doi.org/10.1167/iovs.03-0538
Klinicheskie rekomendatsii. Uveal’naya melanoma. 2020. Available at: https://oncology-association.ru/wp-content/uploads/2020/09/uvealnaja_melanoma.pdf(InRuss.).
Wilson RR. Radiological use of fast protons. Radiology. 1946;47(5):487-491. https://doi.org/10.1148/47.5.487
van Beek JGM, Ramdas WD, Angi M, et al. Local tumour control and radiation side effects for fractionated stereotactic photon beam radiotherapy compared to proton beam radiotherapy in uveal melanoma. Radiother Oncol. 2021;157:219-224. https://doi.org/10.1016/j.radonc.2021.01.030
Smith BR, Hyer DE, Hill PM, Culberson WS. Secondary neutron dose from a dynamic collimation system during intracranial pencil beam scanning proton therapy: a Monte Carlo investigation. Int J Radiat Oncol Biol Phys. 2019;103(1):241-250. https://doi.org/10.1016/j.ijrobp.2018.08.012
Sutherland K, Miyajima S, Date H, et al. A parameter study of pencil beam proton dose distributions for the treatment of ocular melanoma utilizing spot scanning. Radiol Phys Technol. 2010;3(1):16-22. https://doi.org/10.1007/s12194-009-0071-4
Hérault J, Gérard A, Carnicer A, Aloi D, et al. 30 years of ocular proton therapy, the Nice view. Cancer Radiother. 2022;26(8):1016-1026. https://doi.org/10.1016/j.canrad.2022.03.004
Gerard A, Peyrichon ML, Vidal M, et al. Ocular proton therapy, pencil beam scanning high energy proton therapy or stereotactic radiotherapy for uveal melanoma; an in silico study. Cancer Radiother. 2022;26(8):1027-1033. https://doi.org/10.1016/j.canrad.2022.03.003
Belyi YuA, Tereshhenko AV, Volodin PL, Kaplan MA. Fotodinamicheskaya terapiya s fotosensibilizatorom «Fotoditazin» v oftal’mologii. Kaluga: MNTK «Mikrokhirurgiya glaza»; 2008;288. (In Russ.).
Avetisov SE, Budzinskaya MV, Likhvantseva VG. Photodynamic therapy: perspectives of its use in ophthalmology. Vestnik Oftal’mologii. 2005;(5):3-6. (In Russ.).
Barbazetto IA, Lee TC, Rollins IS, et al. Treatment of choroidal melanoma using photodynamic therapy. Am J Ophthalmol. 2003;135(6):898-899. https://doi.org/10.1016/s0002-9394(02)02222-5
Li XY, Tan LC, Dong LW, et al. Susceptibility and resistance mechanisms during photodynamic therapy of melanoma. Front Oncol. 2020;10:597. https://doi.org/10.3389/fonc.2020.00597
Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3(5):380-387. https://doi.org/10.1038/nrc1071
Zharkov VV, Pristupa DV, Mal’kevich VT. Photodynamic therapy in oncology. Photodynamic therapy for lung cancer. Oncology Journal. 2015;9(1):84-93. (In Russ.).
Abakushina EV, Romanko YuS, Kaplan MA, Kaprin AD. Anticancer immune response and photodynamic therapy. Radiation and Risk. 2014;23(4):92-98. (In Russ.).
Panova IE, Boiko EV, Samkovich EV. Melanoma horioidei: kliniko-instrumental’naja diagnostika. St. Petersburg: FGAU NMITs «MNTK «Mikrokhirurgiya glaza» im. akad. S.N. Fedorova» Minzdrava Rossii, SPb filial; 2022;152. (In Russ.).
Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228-247. https://doi.org/10.1016/j.ejca.2008.10.026
Boiko EV, Panova IE, Samkovich EV. Sposob organosokhranyayushchego lecheniya melanomy horioidei na osnove primeneniya gibridnoi fotodinamicheskoi terapii. Patent RU 2 785 609 C1. 09.12.2022. Byulleten’ №34. (In Russ.).
Brovkina AF, Zarubei GD. Ciliochoroidal melanomas treated with a narrow medical proton beam. Arch Ophthalmol. 1986;104(3):402-404. https://doi.org/10.1001/archopht.1986.01050150102037
Damato B. Developments in the management of uveal melanoma. Clin Exp Ophthalmol. 2004;32(6):639-647. https://doi.org/10.1111/j.1442-9071.2004.00917.x
Saakyan SV, Borodin YuI, Shirina TV. Otsenka effektivnosti lecheniya i vyzhivaemosti bol’nykh uveal’noi melanomoi posle lecheniya uzkim meditsinskim protonnym puchkom. In: V Rossiiskii obshchenatsional’nyi oftal’mologicheskii forum. Sbornik nauchnykh trudov. Vol. 2. Moscow; 2012;516-520. (In Russ.).
Regmi R, Maes D, Nevitt A, et al. Treatment of ocular tumors through a novel applicator on a conventional proton pencil beam scanning beamline. Sci Rep. 2022;12(1):4648. https://doi.org/10.1038/s41598-022-08440-5
Jaarsma-Coes MG, Ferreira TA, Marinkovic M, et al. Comparison of magnetic resonance imaging-based and conventional measurements for proton beam therapy of uveal melanoma. Ophthalmol Retina. 2023;7(2):178-188. https://doi.org/10.1016/j.oret.2022.06.019
Foti PV, Inì C, Travali M, et al. MR imaging-pathologic correlation of uveal melanomas undergoing secondary enucleation after proton beam radiotherapy. Appl Sci (Basel). 2021;11(9):4310. https://doi.org/10.3390/app11094310
Toutée A, Angi M, Dureau S, et al. Long-term visual outcomes for small uveal melanoma Staged T1 treated by proton beam radiotherapy. Cancers (Basel). 2019;11(8):1047. https://doi.org/10.3390/cancers11081047
Seibel I, Cordini D, Hager A, et al. Predictive risk factors for radiation retinopathy and optic neuropathy after proton beam therapy for uveal melanoma. Graefes Arch Clin Exp Ophthalmol. 2016;254(9):1787-1792. https://doi.org/10.1007/s00417-016-3429-4

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