The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Panova I.E.

S. Fyodorov Eye Microsurgery Federal State Institution, the St. Petersburg Branch;
North-Western State Medical University named after I.I. Mechnikov;
Saint-Petersburg State University”

Svistunova E.M.

S. Fyodorov Eye Microsurgery Federal State Institution, the St. Petersburg Branch

Samkovich E.V.

S. Fyodorov Eye Microsurgery Federal State Institution, the St. Petersburg Branch

Vorobyev S.L.

National Center for Clinical Morphological Diagnostics

Shatskih A.V.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Kalashnikova E.S.

National Center for Clinical Morphological Diagnostics

Shamanova A.Yu.

Chelyabinsk Regional Clinical Center for Oncology and Nuclear Medicine;
South Ural State Medical University of the Ministry of Health of Russia

Post-radiation choroidal melanoma pathomorphosis assessment in clinical practice

Authors:

Panova I.E., Svistunova E.M., Samkovich E.V., Vorobyev S.L., Shatskih A.V., Kalashnikova E.S., Shamanova A.Yu.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(3): 33‑39

DOI: 10.17116/patol20258703133

Read: 1000 times

Buy for 300₽
Contact the author
Table of contents

POST-RADIATION CHOROIDAL MELANOMA PATHOMORPHOSIS ASSESSMENT IN CLINICAL PRACTICE
POST-RADIATION CHOROIDAL MELANOMA PATHOMORPHOSIS ASSESSMENT IN CLINICAL PRACTICE

To cite this article:

Panova IE, Svistunova EM, Samkovich EV, Vorobyev SL, Shatskih AV, Kalashnikova ES, Shamanova AYu. Post-radiation choroidal melanoma pathomorphosis assessment in clinical practice. Russian Journal of Archive of Pathology. 2025;87(3):33‑39. (In Russ.)
https://doi.org/10.17116/patol20258703133

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Remote resu­lts of treatment of patients with prostate cancer who unde­rwent radiation therapy in a combined version. P.A. Herzen Journal of Onco­logy. 2025;(3):14-19
OCT patterns as a source of errors in the diagnosis of intraocular tumors. Russian Annals of Ophthalmology. 2025;(3):63-70
Proton therapy of skull base chordoma. P.A. Herzen Journal of Onco­logy. 2025;(5):64-67
Abstract:

OBJECTIVE

To study the pathomorphological changes in eyes that underwent secondary enucleation following various types of organ-preserving treatments for choroidal melanoma (CM).

MATERIAL AND METHODS

The study included 22 enucleated eyes with CM. Secondary enucleation was performed between 2 and 120 months after isolated and combined brachytherapy with Ru-106 and Rh-106 radioisotopes, proton therapy, and Gamma Knife treatment. The reasons for enucleation included progressive tumor growth in 12 patients and complications in 10 patients. Pathomorphological examinations were conducted at the National Center for Clinical Morphological Diagnostics, Saint Petersburg.

RESULTS

The majority of the enucleated eyes showed spindle-cell tumors with varying degrees of pigmentation, scleral invasion (95.5%), Bruch’s membrane rupture (90.5%), peri- and intratumoral lymphocytic infiltration (85.7%), signs of perineural invasion (22.7%), and involvement of the optic nerve in the tumor process (28.6%). In the study group, signs of vascular invasion in the tumor parenchyma were observed in only 4.8% of the enucleated eyes. Therapeutic pathomorphosis was evaluated according to Mandard et al. (1994), where TRG4 (60.0%) was frequently diagnosed, and Becker et al. (2003), where TRG3 (65.0%) predominated. The mitotic activity ranged from 1.0 to 5.0 mitoses per 1 mm², with an average of 1.6±1.5.

CONCLUSIONS

The presence of viable tumor cells and their mitotic activity, regardless of the organ-preserving treatment, reflects the absence of the so-called “devitalization” of the tumor and determines the high risk of continued tumor growth and its possible metastasis.

Keywords:

choroidal melanoma
secondary enucleation
post-radiation pathomorphosis
brachytherapy
proton therapy
Gamma Knife

Authors:

Panova I.E.

S. Fyodorov Eye Microsurgery Federal State Institution, the St. Petersburg Branch;
North-Western State Medical University named after I.I. Mechnikov;
Saint-Petersburg State University”

Svistunova E.M.

S. Fyodorov Eye Microsurgery Federal State Institution, the St. Petersburg Branch

Samkovich E.V.

S. Fyodorov Eye Microsurgery Federal State Institution, the St. Petersburg Branch

Vorobyev S.L.

National Center for Clinical Morphological Diagnostics

Shatskih A.V.

S.N. Fedorov National Medical Research Center “MINK “Eye Microsurgery”

Kalashnikova E.S.

National Center for Clinical Morphological Diagnostics

Shamanova A.Yu.

Chelyabinsk Regional Clinical Center for Oncology and Nuclear Medicine;
South Ural State Medical University of the Ministry of Health of Russia

Received:

05.11.2024

Accepted:

26.02.2025

Close metadata

References:

  1. Brovkina AF. Local treatment of choroidal melanoma: possibilities and limitations. Russian Annals of Ophthalmology. (In Russ.). https://doi.org/10.17116/oftalma201813404152
  2. Saakyan SV, Amiryan AG, Val’skii VV, Mironova IS, Tsygankov AYu. Indications for enucleation after uveal melanoma brachytherapy. Russian Ophthalmological Journal. 2016;9(4):46-51. (In Russ.). https://doi.org/10.21516/2072-0076-2016-9-4-46-51
  3. Pham CM, Custer PL, Couch SM. Comparison of primary and secondary enucleation for uveal melanoma. Orbit. 2017;36(6):422-427.  https://doi.org/10.1080/01676830.2017.1337183
  4. Zahorjanová P, Sekáč J, Babál P, Štubňa M. Enucleation after stereotactic radiosurgery in patients with uveal melanoma. Cesk Slov Oftalmol. 2020;76(1):46-51.  https://doi.org/10.31348/2020/6
  5. Fili M, Astrahan M, Stålhammar G. Long-term outcomes after enucleation or plaque brachytherapy of choroidal melanomas touching the optic disc. Brachytherapy. 2021;20(6):1245-1256. https://doi.org/10.1016/j.brachy.2021.05.162
  6. Fabian ID, Tomkins-Netzer O, Stoker I, Arora AK, Sagoo MS, Cohen VM. Secondary enucleation for uveal melanoma: a 7-year retrospective analysis. Am J Ophthalmol. 2015;160(6):1104-1110.e1.  https://doi.org/10.1016/j.ajo.2015.08.034
  7. Roelofsen CD, Wierenga AP, van Duinen S, Verdijk RM, Bleeker J, Marinkovic M, Luyten GPM, Jager MJ. Five decades of enucleations for uveal melanoma in one center: more tumors with high risk factors, no improvement in survival over time. Ocul Oncol Pathol. 2021;7(2):133-141.  https://doi.org/10.1159/000509918
  8. Gill V, Herrspiegel C, Sabazade S, Fili M, Bergman L, Damato B, Seregard S, Stålhammar G. Trends in uveal melanoma presentation and survival during five decades: a nationwide survey of 3898 Swedish patients. Front Med (Lausanne). 2022;9:926034. https://doi.org/10.3389/fmed.2022.926034
  9. Foti PV, Travali M, Farina R, Palmucci S, Spatola C, Liardo RLE, Milazzotto R, Raffaele L, Salamone V, Caltabiano R, et al. Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging — Part II: treatment indications and complications. Insights Imaging. 2021;12(1):67.  https://doi.org/10.1186/s13244-021-01001-w
  10. Fallico M, Raciti G, Longo A, Reibaldi M, Bonfiglio V, Russo A, Caltabiano R, Gattuso G, Falzone L, Avitabile T. Current molecular and clinical insights into uveal melanoma (Review). Int J Oncol. 2021;58(4):10.  https://doi.org/10.3892/ijo.2021.5190
  11. Rapoport YaL. The problem of pathomorphosis. Arkhiv Patologii. 1962;24(2):3-11. (In Russ.).
  12. Lushnikov EF, Abrosimov AYu, Dvinskikh NYu. Pathomorphosis of human tumors. Moscow: SIMK; 2021. 224p. (In Russ.).
  13. Petrovich Z, McDonnell JM, Palmer D, Langholz BM, Liggett PE. Histopathologic changes following irradiation for uveal tract melanoma. Am J Clin Oncol. 1994;17(4):298-306.  https://doi.org/10.1097/00000421-199408000-00004
  14. Magaramov DA, Yarovoi AA, Shatskikh AV, Bulgakova ES. Combined treatment of large choroidal melanoma with ru-106 brachytherapy and transpupillary thermotherapy: morphological changes. Ophthalmosurgery. 2010;(5):38-41. (In Russ.).
  15. Mandard AM, Dalibard F, Mandard JC, Marnay J, Henry-Amar M, Petiot JF, Roussel A, Jacob JH, Segol P, Samama G, et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations. Cancer. 1994;73(11):2680-2686. https://doi.org/10.1002/1097-0142(19940601)73:11<2680::aid-cncr2820731105>3.0.co;2-c
  16. Becker K, Mueller JD, Schulmacher C, Ott K, Fink U, Busch R, Böttcher K, Siewert JR, Höfler H. Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy. Cancer. 2003;98(7):1521-1530. https://doi.org/10.1002/cncr.11660
  17. Zhidkova AS, Kurenkov EL, Panova IE, Brokhman SE. The characteristics of histological structure of uveal melanomas. Morphological Newsletter. 2008;(1-2):236-239. (In Russ.).
  18. Saakyan SV, Amiryan AG, Tsygankov AYu, Sklyarov NV, Zaletaev DV. Clinical, pathomorphological and molecular genetic aspects of uveal melanoma with high metastatic risk. Rossiiskii Oftal’mologicheskii Zhurnal. 2015;8(2):47-52. (In Russ.).
  19. Panova IE, Vlasova OS, Gyuntner EI, Samkovich EV, Shamanova AYu. Determining the risk of metastasis of choroidal melanoma: clinical and instrumental criteria. Russian Ophthalmological Journal. 2019;12(3):30-36. (In Russ.). https://doi.org/10.21516/2072-0076-2019-12-3-30-36
  20. Yarovaya VA, Shatskikh AV, Zaretskii AR, Levashov IA, Volodin DP, Yarovoi AA. Prognostic value of the cell type of uveal melanoma. Russian Journal of Archive of Pathology. 2021;83(4):14-21. (In Russ.). https://doi.org/10.17116/patol20218304114
  21. Brovkina AF, Stoyukhina AS, Chesalin IP. Choroidal melanoma brachytherapy and secondary enucleation. Oftal’mologicheskie Vedomosti. 2014;7(2):69-77. (In Russ.).
  22. Amiryan AG, Brovkina AF, Lelyuk VG. Angioarchitectonics of uveal melanomas. Ophthalmology. 2005;2(1):37-40. (In Russ.).
  23. Panova IE, Samkovich EV, Melikhova MV, Grigor’eva NN. Indocyanine green angiography in the diagnostics of choroidal tumors. Vestnik Oftal’mologii. 2020;136(5):5-13. (in Russian). https://doi.org/10.17116/oftalma20201360515
  24. Shamanova AYu, Kazachkov EL, Panova IE, Vazhenin AV, Shamaeva TN, Alymov TA. Features of the lymphocytic microenvironment in metastatic uveal melanoma. Ural Medical Journal. 2021;20(2): 36-42. (In Russ.). https://doi.org/10.52420/2071-5943-2021-20-2-36-42
  25. Lavnikova GA. Some regularities of radiation pathomorphosis of human tumors and their practical use. Vestnik AMN SSSR. 1976;(6):13-19. (In Russ.).
  26. Glushchenko ES, Slesarvev SM, Moskovkin AA, Plotcev VM, Saenko YV. Differential gene expression and activation of signaling pathways in radioresistant and radiosensitive cancer cell lines. Sovremennye Tekhnologii v Medicine. 2016;8(2):14-20. (In English). https://doi.org/10.17691/stm2016.8.2.02
  27. Avery RB, Diener-West M, Reynolds SM, Grossniklaus HE, Green WR, Albert DM. Histopathologic characteristics of choroidal melanoma in eyes enucleated after iodine 125 brachytherapy in the collaborative ocular melanoma study. Arch Ophthalmol. 2008;126(2):207-212.  https://doi.org/10.1001/archophthalmol.2007.50
  28. Gragoudas ES, Egan KM, Saornil MA, Walsh SM, Albert DM, Seddon JM. The time course of irradiation changes in proton beam-treated uveal melanomas. Ophthalmology. 1993;100(10): 1555-1559; discussion 1560. https://doi.org/10.1016/s0161-6420(93)31445-4
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.