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Brovkina A.F.

Russian Medical Academy of Continuous Professional Education;
Botkin Hospital

Kabardikova L.A.

Russian Medical Academy of Continuous Professional Education;
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin

Shcherbakov P.A.

Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin

Bure I.V.

Russian Medical Academy of Continuous Professional Education

Mirzaev K.B.

Russian Medical Academy of Continuous Postgraduate Education

Uveal melanoma and its local inflammation — good or bad for the patient?

Authors:

Brovkina A.F., Kabardikova L.A., Shcherbakov P.A., Bure I.V., Mirzaev K.B.

More about the authors

Journal: Russian Annals of Ophthalmology. 2025;141(1): 5‑12

DOI: 10.17116/oftalma20251410115

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Table of contents

UVEAL MELANOMA AND ITS LOCAL INFLAMMATION — GOOD OR BAD FOR THE PATIENT?
UVEAL MELANOMA AND ITS LOCAL INFLAMMATION — GOOD OR BAD FOR THE PATIENT?

To cite this article:

Brovkina AF, Kabardikova LA, Shcherbakov PA, Bure IV, Mirzaev KB. Uveal melanoma and its local inflammation — good or bad for the patient? Russian Annals of Ophthalmology. 2025;141(1):5‑12. (In Russ.)
https://doi.org/10.17116/oftalma20251410115

Подписка 2025-2 (Russian Annals of Ophthalmology)
 
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The 21st century is characterized by the study of the features of malignant tumor infiltration by cellular components of the immune system. While some findings suggest a favorable role of lymphoid infiltration in tumors and its positive impact on survival due to immune defense, the opposite is observed in uveal melanoma (UM): lymphoid infiltration significantly worsens the patient’s prognosis. Research on this topic is limited, with some studies confined to experimental models.

PURPOSE

This study investigated the correlation between microRNA-155 expression in the plasma of UM patients after primary enucleation and with pathomorphological inflammatory changes.

MATERIAL AND METHODS

Eighty-three patients with UM were examined, in 21 cases lymphoid infiltration of the primary tumor was detected, in 6 cases accompanied by a microenvironment. The degree of tumor infiltration with lymphocytes was estimated as a percentage of the total number of cells in the analyzed field, ranging from 1% to 25%. Real-time polymerase chain reaction was used to determine microRNA-155 expression in the plasma of all patients before and after enucleation, and its correlation with the level of lymphoid infiltration was analyzed. Postoperative follow-up lasted 6 to 53 months (mean 21.5±14.9 months). In two cases, in the presence of a tumor microenvironment, metastases to the liver were detected 6 and 10 months after enucleation. MicroRNA-155 levels in a volunteer group were used as the control baseline, set at 100% for clarity and convenience.

RESULTS

MicroRNA-155 expression levels were higher in patients with lymphoid infiltration (p<0.05) and tended to increase with the degree of primary tumor infiltration (p<0.001), which in itself, with the appearance of a perifocal lymphoid environment, indicated a poor prognosis.

CONCLUSION

Monitoring microRNA-155 expression levels in the plasma of UM patients may help predict occult metastasis prior to enucleation. This is not only crucial for clinical follow-up but may also play a significant role in the development of targeted therapies.

Keywords:

uveal melanoma
microRNA-155
biomarker
lymphoid infiltration

Authors:

Brovkina A.F.

Russian Medical Academy of Continuous Professional Education;
Botkin Hospital

Kabardikova L.A.

Russian Medical Academy of Continuous Professional Education;
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin

Shcherbakov P.A.

Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin

Bure I.V.

Russian Medical Academy of Continuous Professional Education

Mirzaev K.B.

Russian Medical Academy of Continuous Postgraduate Education

Received:

16.09.2024

Accepted:

06.10.2024

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