The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Brovkina A.F.
Russian Medical Academy of Continuous Professional Education;
Botkin Hospital
Kabardikova L.A.
Russian Medical Academy of Continuous Professional Education;
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin
Shcherbakov P.A.
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin
Mirzaev K.B.
Russian Medical Academy of Continuous Postgraduate Education
Uveal melanoma and its local inflammation — good or bad for the patient?
Journal: Russian Annals of Ophthalmology. 2025;141(1): 5‑12
Views: 482
Downloaded: 2
To cite this article:
Brovkina AF, Kabardikova LA, Shcherbakov PA, Bure IV, Mirzaev KB. Uveal melanoma and its local inflammation — good or bad for the patient? Russian Annals of Ophthalmology.
2025;141(1):5‑12. (In Russ.)
https://doi.org/10.17116/oftalma20251410115
The 21st century is characterized by the study of the features of malignant tumor infiltration by cellular components of the immune system. While some findings suggest a favorable role of lymphoid infiltration in tumors and its positive impact on survival due to immune defense, the opposite is observed in uveal melanoma (UM): lymphoid infiltration significantly worsens the patient’s prognosis. Research on this topic is limited, with some studies confined to experimental models.
This study investigated the correlation between microRNA-155 expression in the plasma of UM patients after primary enucleation and with pathomorphological inflammatory changes.
Eighty-three patients with UM were examined, in 21 cases lymphoid infiltration of the primary tumor was detected, in 6 cases accompanied by a microenvironment. The degree of tumor infiltration with lymphocytes was estimated as a percentage of the total number of cells in the analyzed field, ranging from 1% to 25%. Real-time polymerase chain reaction was used to determine microRNA-155 expression in the plasma of all patients before and after enucleation, and its correlation with the level of lymphoid infiltration was analyzed. Postoperative follow-up lasted 6 to 53 months (mean 21.5±14.9 months). In two cases, in the presence of a tumor microenvironment, metastases to the liver were detected 6 and 10 months after enucleation. MicroRNA-155 levels in a volunteer group were used as the control baseline, set at 100% for clarity and convenience.
MicroRNA-155 expression levels were higher in patients with lymphoid infiltration (p<0.05) and tended to increase with the degree of primary tumor infiltration (p<0.001), which in itself, with the appearance of a perifocal lymphoid environment, indicated a poor prognosis.
Monitoring microRNA-155 expression levels in the plasma of UM patients may help predict occult metastasis prior to enucleation. This is not only crucial for clinical follow-up but may also play a significant role in the development of targeted therapies.
Authors:
Brovkina A.F.
Russian Medical Academy of Continuous Professional Education;
Botkin Hospital
Kabardikova L.A.
Russian Medical Academy of Continuous Professional Education;
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin
Shcherbakov P.A.
Moscow Multidisciplinary Scientific and Clinical Center named after S.P. Botkin
Mirzaev K.B.
Russian Medical Academy of Continuous Postgraduate Education
Received:
16.09.2024
Accepted:
06.10.2024
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.