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Stepanov I.A.

Irkutsk State Medical University

beloborodov V.A.

Irkutsk State Medical University

Shameeva M.A.

Irkutsk State Medical University

Overcoming the blood-brain barrier as a factor for increasing the efficiency of drug therapy for glioblastoma

Authors:

Stepanov I.A., beloborodov V.A., Shameeva M.A.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2023;12(2): 56‑65

DOI: 10.17116/onkolog20231202156

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To cite this article:

Stepanov IA, beloborodov VA, Shameeva MA. Overcoming the blood-brain barrier as a factor for increasing the efficiency of drug therapy for glioblastoma. P.A. Herzen Journal of Oncology. 2023;12(2):56‑65. (In Russ.)
https://doi.org/10.17116/onkolog20231202156

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Gliomas are the most common group of primary brain tumors, accounting for at least 80% of all types of central nervous system neoplasias. High-grade gliomas deserve particular attention due to the unfavorable prognosis of patient survival. Despite the use of the standard treatment protocol for patients with glioblastoma, which is based on surgical treatment, by achieving the maximum degree of tumor tissue resection, on radiation therapy and chemotherapy, only 5% of the patients reach the 5-year survival threshold. One of the main problems of modern fundamental oncology is to overcome the blood-brain barrier (BBB) using various drugs used in patients with central nervous system neoplasias. Literature searching in the Russian and foreign databases has demonstrated that there are several studies of ways to overcome the BBB with various anticancer drugs that are used for high-grade gliomas, including glioblastoma. Combining the results of these studies has been an impetus for writing this literature review.

Keywords:

high-grade gliomas
glioblastoma
blood-brain barrier
blood-brain-tumor barrier
drug delivery

Authors:

Stepanov I.A.

Irkutsk State Medical University

beloborodov V.A.

Irkutsk State Medical University

Shameeva M.A.

Irkutsk State Medical University

Received:

10.05.2022

Accepted:

20.06.2022

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