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Lyadov V.K.

Clinical Oncology Hospital No. 1

Nersesova T.A.

City Clinical Oncology Hospital One of the Moscow Healthcare Department

Pokataev I.A.

City Clinical Oncology Hospital One of the Moscow Healthcare Department

Lyadova M.A.

City Clinical Oncology Hospital One of the Moscow Healthcare Department

Predictors for the development of immune-mediated adverse events during treatment with immune checkpoint inhibitors

Authors:

Lyadov V.K., Nersesova T.A., Pokataev I.A., Lyadova M.A.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2021;10(2): 55‑61

DOI: 10.17116/onkolog20211002155

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Table of contents

PREDICTORS FOR THE DEVELOPMENT OF IMMUNE-MEDIATED ADVERSE EVENTS DURING TREATMENT WITH IMMUNE CHECKPOINT INHIBITORS
PREDICTORS FOR THE DEVELOPMENT OF IMMUNE-MEDIATED ADVERSE EVENTS DURING TREATMENT WITH IMMUNE CHECKPOINT INHIBITORS

To cite this article:

Lyadov VK, Nersesova TA, Pokataev IA, Lyadova MA. Predictors for the development of immune-mediated adverse events during treatment with immune checkpoint inhibitors. P.A. Herzen Journal of Oncology. 2021;10(2):55‑61. (In Russ.)
https://doi.org/10.17116/onkolog20211002155

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
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Abstract:

The use of immune check-point inhibitors has led to a paradigm shift in drug therapy in oncology. The use of anti-CTLA-4 and anti-PD-1/PD-L1 antibodies could achieve a significant increase in objective response and overall survival rates in a number of malignant tumor localizations. Exerting an effect on the immune system, the drugs in this group often lead to the development of immune-mediated adverse toxic reactions, including severe and even fatal ones. The gastrointestinal tract, skin, endocrine glands, liver, and lung are most commonly affected, although any tissue can be a potential target for the development of these autoimmune processes. Searching for the predictors of undesirable adverse reactions is required for the early detection and successful relief of complications of therapy with immune checkpoint inhibitors, as well as for further personalization of therapy for patients with common types of cancer.

Keywords:

immunotherapy
immune-mediated adverse events
sarcopenia

Authors:

Lyadov V.K.

Clinical Oncology Hospital No. 1

Nersesova T.A.

City Clinical Oncology Hospital One of the Moscow Healthcare Department

Pokataev I.A.

City Clinical Oncology Hospital One of the Moscow Healthcare Department

Lyadova M.A.

City Clinical Oncology Hospital One of the Moscow Healthcare Department

Received:

14.10.2020

Accepted:

18.12.2020

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