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Danilova N.V.
Lomonosov Moscow State University
Claudin-18.2 and gastric cancer: from physiology to carcinogenesis
Journal: Russian Journal of Archive of Pathology. 2024;86(6): 92‑99
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To cite this article:
Bunga OD, Danilova NV. Claudin-18.2 and gastric cancer: from physiology to carcinogenesis. Russian Journal of Archive of Pathology.
2024;86(6):92‑99. (In Russ.)
https://doi.org/10.17116/patol20248606192
Today a global problem for humanity is represented by cancer, in particular gastric cancer, which is characterized by high mortality and aggressive course. In this regard, there is a search for new approaches to the diagnosis and therapy of gastric cancer, one of these areas is the study of the expression level of the intercellular adhesion molecule claudin-18.2 in tumor tissue and its use as a target molecule. In the case of various pathological processes, including tumors, the expression profile of claudin-18.2 changes, which indicates its possible role in the initiation and progression of cancer. The aim of this review is to systematize the data on claudin-18.2, its role in normal cell physiology and embryology, as well as in the development of pathological processes in the stomach, its relation to the clinical and morphological characteristics of gastric cancer and importance in biological therapy.
Keywords:
Authors:
Danilova N.V.
Lomonosov Moscow State University
Received:
08.05.2024
Accepted:
26.06.2024
List of references:
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