The statistical data available in modern literature demonstrate a steady rise in the incidence of reproductive system cancer in the female population. Ultrasound imaging is of great importance in the diagnosis of this pathology. One of the ultrasound diagnostic techniques is sonohysterosalpingography (SHSG) that is most commonly used in obstetric practice. The available foreign and Russian literature also contains data on the efficiency of its use in gynecology, including in the diagnosis of endometrial cancer. The results of works devoted to the diagnosis of endometrial cancer demonstrate the need for larger-scale studies to reliably assess all the possibilities of this technique. Eight patients with endometrial cancer underwent a pilot examination supplemented with SHSG in the Department of Ultrasound Diagnosis and the Department of Gynecological Oncology of the P.A. Herzen Moscow Oncology Research Institute. The results showed that the technique had good efficiency in determining the depth of endometrial cancer invasion; however, with allowance made for a small number of patients, further investigation is slated.