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Kotel'nikova N.A.

Samara State Medical University

Balter R.B.

Samara State Medical University

Tselkovich L.S.

Samara State Medical University

Ivanova T.V.

Samara State Medical University

Il'chenko O.A.

Samara State Medical University

Medvedchikova-Ardiya L.K.

Samara State Medical University

Prognosis and prevention of recurrent and atypical endometrial hyperplasia in women of reproductive age

Authors:

Kotel'nikova N.A., Balter R.B., Tselkovich L.S., Ivanova T.V., Il'chenko O.A., Medvedchikova-Ardiya L.K.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2024;24(6): 59‑65

DOI: 10.17116/rosakush20242406159

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Table of contents

PROGNOSIS AND PREVENTION OF RECURRENT AND ATYPICAL ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE
PROGNOSIS AND PREVENTION OF RECURRENT AND ATYPICAL ENDOMETRIAL HYPERPLASIA IN WOMEN OF REPRODUCTIVE AGE

To cite this article:

Kotel'nikova NA, Balter RB, Tselkovich LS, Ivanova TV, Il'chenko OA, Medvedchikova-Ardiya LK. Prognosis and prevention of recurrent and atypical endometrial hyperplasia in women of reproductive age. Russian Bulletin of Obstetrician-Gynecologist. 2024;24(6):59‑65. (In Russ.)
https://doi.org/10.17116/rosakush20242406159

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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Based on the analytical review of the literature, the approaches to the issues of prognosis and prevention of recurrent and atypical endometrial hyperplasia were systematized by identifying the main markers of cellular regulatory activity. Preoncological lesions of the endometrium can be predicted using the main diagnostic �tools�: hormonal background studies, since hyperestrogen-ism is the main element of the mechanism of endometrial hyperplasia development; ultrasound diagnostics; magnetic resonance imaging, immunohistochemical studies, biomarker studies, com-puter morphometry, etc. However, a complete diagnosis is possible only with a morphological study that establishes the criteria for cellular and tissue pathological changes. Histological exami-nation of chronic endometritis in women of reproductive age reveals disorders of proliferation and secretion of the endometrium, provoking the development of endometrial hyperplasia. The necessary measures aimed at preventing recurrence of endometrial hyperplasia and reducing the risk of developing atypical endometrial hyperplasia in women of reproductive age are in time di-agnosis and treatment of inflammatory diseases of the pelvic organs, correction of hormonal dis-orders, control over body weight and its correction, annual examinations by a gynecologist, ultra-sound of the pelvic organs, observation by a general practitioner and endocrinologist in the pres-ence of risk factors for the development of endometrial hyperplasia.

Keywords:

atypical endometrial hyperplasia
endometrial cancer
biomarkers
malignancy
female reproductive age
recurrence of endometrial hyperplasia
hormonal background
pathomorpholog-ical processes
immunohistochemical studies

Authors:

Kotel'nikova N.A.

Samara State Medical University

Balter R.B.

Samara State Medical University

Tselkovich L.S.

Samara State Medical University

Ivanova T.V.

Samara State Medical University

Il'chenko O.A.

Samara State Medical University

Medvedchikova-Ardiya L.K.

Samara State Medical University

Received:

18.09.2024

Accepted:

25.09.2024

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