The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Nenasheva V.V.

National Research Centre “Kurchatov Institute”

Tarantul V.Z.

National Research Center «Kurchatov Institute»

The role of the TRIM gene superfamily in the estrogen receptor alpha signaling pathway in the development of hormone-dependent breast cancer

Authors:

Nenasheva V.V., Tarantul V.Z.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2025;43(4‑2): 64‑67

DOI: 10.17116/molgen20254304264

Read: 349 times

Contact the author
Table of contents

THE ROLE OF THE TRIM GENE SUPERFAMILY IN THE ESTROGEN RECEPTOR ALPHA SIGNALING PATHWAY IN THE DEVELOPMENT OF HORMONE-DEPENDENT BREAST CANCER
THE ROLE OF THE TRIM GENE SUPERFAMILY IN THE ESTROGEN RECEPTOR ALPHA SIGNALING PATHWAY IN THE DEVELOPMENT OF HORMONE-DEPENDENT BREAST CANCER

To cite this article:

Nenasheva VV, Tarantul VZ. The role of the TRIM gene superfamily in the estrogen receptor alpha signaling pathway in the development of hormone-dependent breast cancer. Molecular Genetics, Microbiology and Virology. 2025;43(4‑2):64‑67. (In Russ.)
https://doi.org/10.17116/molgen20254304264

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Guidelines for asse­ssing the quality of mammographic images. Russian Journal of Preventive Medi­cine. 2025;(6):21-32
Hema­tological indi­cators of the systemic inflammatory response in the prognosis of lumi­nal HER2-negative breast cancer patients unde­rgoing surgery followed by adju­vant therapy. P.A. Herzen Journal of Onco­logy. 2025;(3):31-38
Hemo­stasis diso­rders during neoadjuvant therapy in patients with breast cancer. P.A. Herzen Journal of Onco­logy. 2025;(3):39-44
Inci­dence of regional lymph node meta­stases in patients with early prognostically unfa­vorable mole­cular biological breast cancer. Piro­gov Russian Journal of Surgery. 2025;(7):11-15
Auto­logous fat transplantation into post-lymphadenectomy cavity for prevention of lymphorrhea after total mastectomy. Piro­gov Russian Journal of Surgery. 2025;(7):24-35
Biopsy of the sentinel lymph node and the possibility of performing breast-conserving surgery for the non-inflammatory inva­sive breast cancers with edema. P.A. Herzen Journal of Onco­logy. 2025;(4):96-101
Radiation damage to the lungs and heart in a patient after radiation therapy for breast cancer. Journal of Respiratory Medi­cine. 2025;(3):79-84
Modern diagnosis of lymphedema. Plastic Surgery and Aesthetic Medi­cine. 2025;(3-2):104-109
Multidisciplinary aspe­cts of pregnancy mana­gement in mate­rnal cancer and fetal malformations. Russian Bulletin of Obstetrician-Gynecologist. 2025;(6):69-76
Abstract:

Breast cancer (BC) is the most frequently diagnosed cancer and the second leading cause of cancer death among women worldwide. Decades of research into the molecular mechanisms of BC development have identified numerous genes involved in this pathological process. In this review, we describe new data on the important role of the TRIM gene superfamily, encoding proteins containing a TRIpartite Motif, in BC pathogenesis. Extensive data has accumulated on the functioning of TRIMs in hormone-dependent BC, and new insights are being gained every day. Particular attention is paid to the diverse mechanisms by which TRIM proteins influence the estrogen receptor alpha (ERα) signaling pathway during the development of ER-positive BC and the development of chemoresistance during chemotherapy in this tumor type.

Keywords:

TRIM multifamily proteins
breast cancer
estrogen receptor alpha signaling pathway
chemoresistance/

Authors:

Nenasheva V.V.

National Research Centre “Kurchatov Institute”

Tarantul V.Z.

National Research Center «Kurchatov Institute»

Received:

30.09.2025

Accepted:

17.10.2025

Close metadata

References:

  1. Key T, Appleby P, Barnes I, Reeves G. Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J. Natl. Cancer Inst. 2002;94(8):606-16.  https://doi.org/10.1093/jnci/94.8.606
  2. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet. 2002;360(9328):187-95.  https://doi.org/10.1016/S0140-6736(02)09454-0
  3. Lamb CA, Vanzulli SI, Lanari C. Hormone receptors in breast cancer: more than estrogen receptors. Medicina (B Aires). 2019;79(Spec 6/1):540-545. 
  4. Bai X, Tang J. TRIM proteins in breast cancer: Function and mechanism. Biochem Biophys Res Commun. 2023;640:26-31.  https://doi.org/10.1016/j.bbrc.2022.11.103
  5. Cao J, Yang M, Guo D, Tao Z, Hu X. Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer. Cancer Med. 2024;13(14):e7472. https://doi.org/10.1002/cam4.7472
  6. Hatakeyama S. TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis. Trends Biochem Sci. 2017;42(4):297-311.  https://doi.org/10.1016/j.tibs.2017.01.002
  7. Venuto S, Merla G. E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis. Cells. 2019;8(5):510.  https://doi.org/10.3390/cells8050510
  8. Nenasheva VV, Tarantul VZ. Many Faces of TRIM Proteins on the Road from Pluripotency to Neurogenesis. Stem Cells Dev. 2020;29(1):1-14.  https://doi.org/10.1089/scd.2019.0152
  9. Sardiello M, Cairo S, Fontanella B, Ballabio A, Meroni G. Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. BMC Evol Biol. 2008;8:225.  https://doi.org/10.1186/1471-2148-8-225
  10. Esposito D, Koliopoulos MG, Rittinger K. Structural determinants of TRIM protein function. Biochem Soc Trans. 2017;45(1):183-191.  https://doi.org/10.1042/BST20160325
  11. Voutsadakis IA. Breast Cancers With Intermediate Estrogen Receptor Expression: Characteristics, Prognosis and Treatment. Clin Breast Cancer. 2025;25(3):214-222.  https://doi.org/10.1016/j.clbc.2024.11.020
  12. Siersbæk R, Kumar S, Carroll JS. Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer. Genes Dev. 2018;32(17-18):1141-1154. https://doi.org/10.1101/gad.316646.118
  13. Rusidzé M, Adlanmérini M, Chantalat E, Raymond-Letron I, Cayre S, Arnal JF, et al. Estrogen receptor-α signaling in post-natal mammary development and breast cancers. Cell Mol Life Sci. 2021;78(15):5681-5705. https://doi.org/10.1007/s00018-021-03860-4
  14. Ye R, AiErken N, Kuang X, Zeng H, Shao N, Lin Y, et al. Tripartite motif-containing 3 (TRIM3) enhances ER signaling and confers tamoxifen resistance in breast cancer. Oncogenesis. 2021;10(9):60.  https://doi.org/10.1038/s41389-021-00350-x
  15. Zhuang T, Wang B, Tan X, Wu L, Li X, Li Z, et al. TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression. Cell Commun Signal. 2022;20(1):45.  https://doi.org/10.1186/s12964-022-00861-z
  16. Tang J, Luo Y, Tian Z, Liao X, Cui Q, Yang Q, et al. TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α. Neoplasia. 2020;22(9):343-351.  https://doi.org/10.1016/j.neo.2020.06.003
  17. Xue M, Zhang K, Mu K, Xu J, Yang H, Liu Y, et al. Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56. Oncogenesis. 2019;8(5):30.  https://doi.org/10.1038/s41389-019-0139-x
  18. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, et al. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010; 468(7326):927-932.  https://doi.org/10.1038/nature09542
  19. Fu L, Ma B, Zhang L, Xu H, Chen W, Wu D, et al. ERα Coregulator TRIM28 Promotes Breast Cancer Progression by Activating the AKT/GSK3β Pathway. Environ Toxicol. 2024;39(11):5162-5172. https://doi.org/10.1002/tox.24373
  20. Romo BA, Karakyriakou B, Cressey L, Brauer BL, Yang H, Warren A, et al. TRIM33 Is a Co-Regulator of Estrogen Receptor Alpha. Cancers (Basel). 2024;16(5):845.  https://doi.org/10.3390/cancers16050845
  21. Padrão N, Gregoricchio S, Eickhoff N, Dong J, Luzietti L, Bossi D, et al. TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer. Proc Natl Acad Sci U S A. 2025;122(33):e2507571122. https://doi.org/10.1073/pnas.2507571122
  22. Tian Z, Tang J, Liao X, Gong Y, Yang Q, Wu Y, et al. TRIM8 inhibits breast cancer proliferation by regulating estrogen signaling. Am J Cancer Res. 2020;10(10):3440-3457.
  23. Das N, Datta N, Chatterjee U, Ghosh MK. Estrogen receptor alpha transcriptionally activates casein kinase 2 alpha: A pivotal regulator of promyelocytic leukaemia protein (PML) and AKT in oncogenesis. Cell Signal. 2016;28(6):675-687.  https://doi.org/10.1016/j.cellsig.2016.03.007
  24. Zhou Y, Liu X. The role of estrogen receptor beta in breast cancer. Biomark Res. 2020;8:39.  https://doi.org/10.1186/s40364-020-00223-2
  25. Datta N, Islam S, Chatterjee U, Chatterjee S, Panda CK, Ghosh MK. Promyelocytic Leukemia (PML) gene regulation: implication towards curbing oncogenesis. Cell Death Dis. 2019;10(9):656.  https://doi.org/10.1038/s41419-019-1889-2
  26. Liu J, Welm B, Boucher KM, Ebbert MT, Bernard PS. TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer. Am J Pathol. 2012;180(2):839-847.  https://doi.org/10.1016/j.ajpath.2011.10.020
  27. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett. 2000;472(1):9-13.  https://doi.org/10.1016/s0014-5793(00)01421-6
  28. Nakajima A, Maruyama S, Bohgaki M, Miyajima N, Tsukiyama T, Sakuragi N, et al. Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP. Biochem Biophys Res Commun. 2007;357(1):245-251.  https://doi.org/10.1016/j.bbrc.2007.03.134
  29. Dong XY, Fu X, Fan S, Guo P, Su D, Dong JT. Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. Biochem J. 2012;444(3):581-590.  https://doi.org/10.1042/BJ20111890
  30. Belachew EB, Sewasew DT. Molecular mechanisms of endocrine resistance in estrogen-positive breast cancer. Front Endocrinol. 2021;12:599586. https://doi.org/10.3389/fendo.2021.599586.
  31. Han D, Wang L, Long L, Su P, Luo D, Zhang H, et al. The E3 Ligase TRIM4 Facilitates SET Ubiquitin-Mediated Degradation to Enhance ER-α Action in Breast Cancer. Adv Sci (Weinh). 2022;9(25):e2201701. https://doi.org/10.1002/advs.202201701
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.