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Belysheva T.S.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia;
Central state medical academy of department of presidential affairs, Moscow, Russia

Krivova E.V.

Central state medical academy of department of presidential affairs, Moscow, Russia

Baranova N.P.

St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

Neznakhina M.S.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Shlivko I.L.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Sagoyan G.B.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kruglova L.S.

Central state medical academy of department of presidential affairs, Moscow, Russia

Polyakov V.G.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia;
«Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Romantsova O.M.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Rubanskaya M.V.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kerimov P.A.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kirgizov K.I.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Varfolomeeva S.R.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia;
«Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia

Prevention and background therapy of skin toxic reactions in children receiving antitumor drug therapy. Part 2 (results of prospective cohort study)

Authors:

Belysheva T.S., Krivova E.V., Baranova N.P., Neznakhina M.S., Shlivko I.L., Sagoyan G.B., Kruglova L.S., Polyakov V.G., Romantsova O.M., Rubanskaya M.V., Kerimov P.A., Kirgizov K.I., Varfolomeeva S.R.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2026;25(1): 113‑120

DOI: 10.17116/klinderma202625011113

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Table of contents

PREVENTION AND BACKGROUND THERAPY OF SKIN TOXIC REACTIONS IN CHILDREN RECEIVING ANTITUMOR DRUG THERAPY. PART 2 (RESULTS OF PROSPECTIVE COHORT STUDY)
PREVENTION AND BACKGROUND THERAPY OF SKIN TOXIC REACTIONS IN CHILDREN RECEIVING ANTITUMOR DRUG THERAPY. PART 2 (RESULTS OF PROSPECTIVE COHORT STUDY)

To cite this article:

Belysheva TS, Krivova EV, Baranova NP, et al. Prevention and background therapy of skin toxic reactions in children receiving antitumor drug therapy. Part 2 (results of prospective cohort study). Russian Journal of Clinical Dermatology and Venereology. 2026;25(1):113‑120. (In Russ.)
https://doi.org/10.17116/klinderma202625011113

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The success of treatment of childhood malignant tumors is related to the improvement of antitumor drug treatment protocols. However, these agents cause toxicity, most often — skin toxic reactions. Prevention and treatment of dermal toxicity are evolving with emergence of new knowledge about the mechanisms of action of antitumor drugs and understanding of the pathogenesis of drug-induced cutaneous reactions.

OBJECTIVE

To prove the efficacy and safety of the use of background therapy and moisturizers in children receiving systemic drug antitumor treatment.

MATERIAL AND METHODS

A multicenter prospective observational study, which included 60 patients, was implemented in the L.A. Durnova Research Institute of Children’s Oncology and Hematology of the N.N. Blokhin National Medical Research Center of Oncology for 3 years (October 2022 — October 2025). Patients were divided into 2 groups: receiving background therapy for skin toxic reactions (the 1st group) and combination of background therapy with moisturizing agents (the 2nd group). Median age was 8 years in the 1st group, 9 years in the 2nd. Gender distribution in the 1st group — 43.5% were boys and 56.5% were girls; in the 2nd group — 54.5% and 45.5%, respectively.

RESULTS

Statistically significant differences were not found (p=0.16) when comparing functional indicators of the skin in the 1st and 2nd groups, but there was a tendency to a more pronounced improvement in the dynamics of the indicators (reduction of itching, pain sensation and skin dryness) in the 2nd group. Patients of the 2nd group reported a faster regression of skin toxic reactions and a high level of comfort.

CONCLUSION

Prevention and timely monitoring of skin toxic reactions is an integral part of the comprehensive management of patients receiving antitumor therapy. The use of background therapy and moisturizers depending on the severity, as well as the multidisciplinary interaction of oncologist and dermatologist, allow to control the skin toxicity without the need to interrupt vital antitumor treatment.

Keywords:

chemotherapy
skin toxic reactions
hand-foot syndrome
xerosis
acne-like rash
maculopapular rash
children

Authors:

Belysheva T.S.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia;
Central state medical academy of department of presidential affairs, Moscow, Russia

Krivova E.V.

Central state medical academy of department of presidential affairs, Moscow, Russia

Baranova N.P.

St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

Neznakhina M.S.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Shlivko I.L.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Sagoyan G.B.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kruglova L.S.

Central state medical academy of department of presidential affairs, Moscow, Russia

Polyakov V.G.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia;
«Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia;
Pirogov Russian National Research Medical University, Moscow, Russia

Romantsova O.M.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Rubanskaya M.V.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kerimov P.A.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Kirgizov K.I.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia

Varfolomeeva S.R.

«N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation, Moscow, Russia;
«Russian Medical Academy of Continuous Professional Education» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia

Received:

13.01.2026

Accepted:

31.01.2026

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References:

  1. Leonardi MC, et al. A Double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis. Eur J Dermatol. 2008;18(3):317-321. 
  2. Aries MF, et al. Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract in in vitro models. Clin Cosmet Investig Dermatol. 2016;9:421-434.  https://doi.org/10.2147/CCID.S113180
  3. Martin H, et al. Aquaphilus dolomiae extract counteracts the CD4+ T cell activation of S. aureus cutaneous secretome from atopic children. Pharm Biol. 2016;54(11):2782-2785. https://doi.org/10.3109/13880209.2016.1173069
  4. Bianchi P, et al. Effects of a new emollient-based treatment on skin microflora balance and barrier function in children with mild Atopic Dermatitis. Pediatr Dermatol. 2016;33(2):165-171.  https://doi.org/10.1111/pde.12786
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