Over the years, psoriasis has been an important medical problem from the earliest times. Psoriasis is not only limited to skin manifestations, but often affects internal organs and is aggravated by polymorbid pathology. Psoriasis is associated with significant deterioration in the quality and duration of life. An evolution of the processes of diagnosis, study of pathogenesis and treatment of this disease is observed. Psoriasis treatment regimens are constantly being improved. External treatment methods and systemic drugs are known. The patient’s therapeutic regimen should include individual approach, depending on the severity of psoriasis, presence of extracutaneous manifestations and concomitant pathology. It is difficult to determine the right individual treatment for each patient with psoriasis, therefore researchers are striving to find faster and more effective, but at the same time safe and precise methods. Psoriasis treatment methods, which have been used over the past 100 years, are considered in the review. Many treatments have become a part of history, some are still used today. Current therapeutic recommendations are focused on the implementation of the «treat-to-target» (T2T) strategy and are aimed at increasing patient adherence, that is of paramount importance for achieving therapeutic success.