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Shtina I.E.

Federal Research Center for Medical and Preventive Technologies for Managing Public Health Risks

Ustinova O.Yu.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Zenina M.T.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»

Boltacheva A.N.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Mamykina N.I.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»

Structural and functional characteristic of thyroid gland in children and adolescents with alopecia areata by data of laboratory and ultrasound examination

Authors:

Shtina I.E., Ustinova O.Yu., Zenina M.T., Boltacheva A.N., Mamykina N.I.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(2): 214‑220

DOI: 10.17116/klinderma202423021214

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To cite this article:

Shtina IE, Ustinova OYu, Zenina MT, Boltacheva AN, Mamykina NI. Structural and functional characteristic of thyroid gland in children and adolescents with alopecia areata by data of laboratory and ultrasound examination. Russian Journal of Clinical Dermatology and Venereology. 2024;23(2):214‑220. (In Russ.)
https://doi.org/10.17116/klinderma202423021214

Подписка 2025 (Russian Journal of Clinical Dermatology and Venereology)
 
МСФ на ЯМ
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BACKGROUND

One of the most common comorbid conditions of alopecia in adults s diseases of thyroid gland (TG). The relevant literature data on TG disorders in children are limited. The evaluation of thyroid status requires further researches according to the guidelines on alopecia areata.

OBJECTIVE

To study structural and functional characteristic of thyroid gland in children and adolescents with alopecia areata by data of laboratory and ultrasound examination.

MATERIAL AND METHODS

The study group consisted of 123 children with «alopecia» diagnosis (local, subtotal and total types), mean age was 10.8±3.4 years, comparison group included 250 children without alopecia aged 10.4±3.2 years. All children were tested to determine TSH, free T4, antibodies to TPO and TG, ultrasound of TG.

RESULTS

Alopecia in children and adolescents was diagnosed in equal proportion among females and males (p=0.471). The children of study group have a statistically significantly greater median of free T4, antibodies to TPO and TG with lower value of median of TSH (p<0.001–0.031) and without intergroup difference in the incidence of detected findings. At the same time, the increase in the TG volume, diffuse alterations of structure in the form of autoimmune thyroiditis, focal and minimal changes of TG structure, as well as the presence of lymph nodes near the lower pole of TG lobe were found statistically significantly more often during ultrasound. The correlation analysis showed statistically significant direct correlations between the mild and moderate intensity of baldness volume with the presence of an increase in volume, different types of changes in the TG structure and lymph nodes near the lower pole of TG lobe.

CONCLUSION

Morphometric disorders of TG by data of ultrasound without laboratory changes of thyroid status have been statistically significantly more often registered in children and adolescents with alopecia areata.

Keywords:

alopecia
thyroid gland
children
adolescents
ultrasound
hormonal status

Authors:

Shtina I.E.

Federal Research Center for Medical and Preventive Technologies for Managing Public Health Risks

Ustinova O.Yu.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Zenina M.T.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»

Boltacheva A.N.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Mamykina N.I.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies»

Received:

17.10.2023

Accepted:

29.01.2024

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