The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Abramov D.S.

Dmitry Rogachev National Medical Research Center of pediatric hematology, oncology and immunology

Fedorova A.S.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Tuzova E.A.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Myakova N.V.

Dmitry Rogachev National Medical Research Center of pediatric hematology, oncology and immunology

Konovalov D.M.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology;
Russian Medical Academy of Continuous Professional Education

ALK-positive anaplastic large cell lymphoma of paranasal sinuses: two cases report and literature review

Authors:

Abramov D.S., Fedorova A.S., Tuzova E.A., Myakova N.V., Konovalov D.M.

More about the authors

Read: 1935 times


To cite this article:

Abramov DS, Fedorova AS, Tuzova EA, Myakova NV, Konovalov DM. ALK-positive anaplastic large cell lymphoma of paranasal sinuses: two cases report and literature review. Russian Journal of Archive of Pathology. 2024;86(4):42‑47. (In Russ.)
https://doi.org/10.17116/patol20248604142

Recommended articles:
Autoimmune diseases of central nervous system and respiratory viral infe­ctions in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):39-46
Foreign body of ethmoidal air cells. Russian Rhinology. 2025;(1):72-75
On the issue of classification of vomer defo­rmities in children. Russian Bulletin of Otorhinolaryngology. 2025;(1):35-42
Surgical treatment of pulmonary tube­rculosis in children and adolescents. Piro­gov Russian Journal of Surgery. 2025;(3):16-23

References:

  1. Falini B, Lamant L, Campo E, Jaffe ES, Gascoyne RD, Stein H et al. Anaplastic large cell lymphoma, alk positive. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, eds. Who Classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon (France): IARC; 2017;413-418. 
  2. Chiarle R, Voena C, Ambrogio C, Piva R, Inghirami G. The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer. 2008;8(1):11-23.  https://doi.org/10.1038/NRC2291
  3. Stein H, Foss HD, Durkop H, Marafioti T, Delsol G, Pulford K et al. CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood. 2000;96(12):3681-3695. https://doi.org/10.1182/BLOOD.V96.12.3681
  4. Greer JP, Kinney MC, Collins RD, Salhany KE, Wolff SN, Hainsworth JD et al. Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma. J Clin Oncol. 2016;9(4):539-547.  https://doi.org/10.1200/JCO.1991.9.4.539
  5. Falini B, Pileri S, Zinzani PL, Carbone A, Zagonel V, Wolf-Peeters C et al. ALK+ Lymphoma: Clinico-Pathological Findings and Outcome. Blood. 1999;93(8):2697-2706. https://doi.org/10.1182/BLOOD.V93.8.2697
  6. Stadler S, Singh VK, Knörr F, Damm-Welk C, Woessmann W. Immune Response against ALK in Children with ALK-Positive Anaplastic Large Cell Lymphoma. Cancers (Basel). 2018;10(4): E114-E114. https://doi.org/10.3390/CANCERS10040114
  7. Lakshmaiah K, Guruprasad B, Shah A, Kavitha S, Abraham L, Govindbabu K et al. Anaplastic large cell lymphoma: a single institution experience from India. J Cancer Res Ther. 2013;9(4):649-652.  https://doi.org/10.4103/0973-1482.126468
  8. Xie Y, Pittaluga S, Jaffe ES. The Histological Classification of Diffuse Large B-cell Lymphomas. Semin Hematol. 2015;52(2):57.  https://doi.org/10.1053/J.SEMINHEMATOL.2015.01.006
  9. Kolokotronis A, Konstantinou N, Christakis I, Papadimitriou P, Matiakis A, Zaraboukas T et al. Localized B-cell non-Hodgkin’s lymphoma of oral cavity and maxillofacial region: A clinical study. Oral Surgery, Oral Med Oral Pathol Oral Radiol Endodontology. 2005;99(3):303-310.  https://doi.org/10.1016/j.tripleo.2004.03.028
  10. Khalil MO, Morton LM, Devesa SS, Check DP, Curtis RE, Weisenburger DD et al. Incidence of marginal zone lymphoma in the United States, 2001—2009 with a focus on primary anatomic site. Br J Haematol. 2014;165(1):67-77.  https://doi.org/10.1111/BJH.12730
  11. Lin P, Molina TJ, Cook JR, Swerdlow SH. Lymphoplasmacytic Lymphoma and Other Non—Marginal Zone Lymphomas With Plasmacytic Differentiation. Am J Clin Pathol. 2011;136(2):195-210.  https://doi.org/10.1309/AJCP8FOIVTB6LBER
  12. Swerdlow SH, Kuzu I, Dogan A, Dirnhofer S, Chan JKC, Sander B et al. The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing. Virchows Arch. 2016;468(3):259-275.  https://doi.org/10.1007/S00428-015-1858-9/FIGURES/11
  13. Lamant L, McCarthy K, D’Amore E, Klapper W, Nakagawa A, Fraga M et al. Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study. J Clin Oncol. 2011;29(35):4669-4676. https://doi.org/10.1200/JCO.2011.36.5411
  14. Fraga M, Brousset P, Schlaifer D, Payen C, Robert A, Rubie H et al. Bone Marrow Involvement in Anaplastic Large Cell Lymphoma: Immunohistochemical Detection of Minimal Disease and Its Prognostic Significance. Am J Clin Pathol. 1995;103(1):82-89.  https://doi.org/10.1093/AJCP/103.1.82
  15. Pasqualini C, Minard-Colin V, Saada V, Lamant L, Delsol G, Patte C et al. Clinical analysis and prognostic significance of haemophagocytic lymphohistiocytosis‐associated anaplastic large cell lymphoma in children. Br J Haematol. 2014;1(165):117-125.  https://doi.org/10.1111/BJH.12728
  16. Tole S, Wheaton L, Alexander S. Pediatric Anaplastic Large Cell Lymphoma — A Review. Oncol Hematol Rev. 2018;14(1):21-27. 
  17. Armitage JO. Staging Non-Hodgkin Lymphoma. CA Cancer J Clin. 2005;55(6):368-376.  https://doi.org/10.3322/CANJCLIN.55.6.368
  18. Morris SW, Kirstein MN, Valentine MB, Dittmer KG, Shapiro DN, Saltman DL et al. Fusion of a Kinase Gene, ALK, to a Nucleolar Protein Gene, NPM, in Non-Hodgkin’s Lymphoma. Science (80-). 1994;263(5151):1281-1284. https://doi.org/10.1126/SCIENCE.8122112
  19. Grisendi S, Mecucci C, Falini B, Pandolfi PP. Nucleophosmin and cancer. Nat Rev Cancer. 2006;6(7):493-505.  https://doi.org/10.1038/NRC1885
  20. Cools J, Wlodarska I, Somers R, Mentens N, Pedeutour F, Maes B et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 2002;34(4):354-362.  https://doi.org/10.1002/GCC.10033
  21. Hernández L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A et al. Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity. Am J Pathol. 2002;160(4):1487-1494. https://doi.org/10.1016/S0002-9440(10)62574-6
  22. Lamant L, Dastugue N, Pulford K, Delsol G, Mariamé B. A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. Blood. 1999;93(9):3088-3095. https://doi.org/10.1182/blood.v93.9.3088.409k30_3088_3095
  23. Meech SJ, McGavran L, Odom LF, Liang X, Maltesen L, Gump J et al. Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4 — anaplastic lymphoma kinase gene fusion. Blood. 2001;98(4):1209-1216. https://doi.org/10.1182/BLOOD.V98.4.1209
  24. Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M et al. Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma. Genes Chromosomes Cancer. 2003;37(4):427-432.  https://doi.org/10.1002/GCC.10232
  25. Touriol C, Greenland C, Lamant L, Pulford K, Bernard F, Rousset T et al. Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like). Blood. 2000;95(10):3204-3207. https://doi.org/10.1182/blood.v95.10.3204.010k04_3204_3207
  26. Colleoni GWB, Bridge JA, Garicochea B, Liu J, Filippa DA, Ladanyi M. ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35). Am J Pathol. 2000; 156(3):781-789.  https://doi.org/10.1016/S0002-9440(10)64945-0
  27. Tort F, Pinyol M, Pulford K, Roncador G, Hernandez L, Nayach I et al. Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. Lab Invest. 2001;81(3):419-426.  https://doi.org/10.1038/LABINVEST.3780249
  28. Wang H, Wei W, Zhang JP, Song Z, Li Y, Xiao W et al. A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma. Leukemia. 2020;35(7):1976-1989. https://doi.org/10.1038/S41375-020-01088-Y
  29. Kasprzycka M, Marzec M, Liu X, Zhang Q, Wasik MA. Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3. Proc Natl Acad Sci. 2006;103(26):9964-9969. https://doi.org/10.1073/PNAS.0603507103
  30. Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N et al. miR-135b mediates NPM-ALK — driven oncogenicity and renders IL-17—producing immunophenotype to anaplastic large cell lymphoma. Blood. 2011;118(26):6881-6892. https://doi.org/10.1182/BLOOD-2011-05-354654
  31. Eckerle S, Brune V, Döring C, Tiacci E, Bohle V, Sundström C et al. Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma. Leukemia. 2009;23(11): 2129-2138. https://doi.org/10.1038/LEU.2009.161
  32. Laurent C, Lopez C, Desjobert C, Berrebi A, Damm-Welk C, Delsol G et al. Circulating t(2;5)-positive cells can be detected in cord blood of healthy newborns. Leukemia. 2011;26(1):188-190.  https://doi.org/10.1038/LEU.2011.209
  33. Moti N, Malcolm T, Hamoudi R, Mian S, Garland G, Hook CE et al. Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin. Oncogene. 2014;34(14):1843-1852. https://doi.org/10.1038/ONC.2014.112
  34. Malcolm TIM, Villarese P, Fairbairn CJ, Lamant L, Trinquand A, Hook CE et al. Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. Nat Commun. 2016;7:10087-10087. https://doi.org/10.1038/NCOMMS10087
  35. Benharroch D, Meguerian-Bedoyan Z, Lamant L, Amin C, Brugières L, Terrier-Lacombe MJ et al. ALK-positive lymphoma: A single disease with a broad spectrum of morphology. Blood. 1998; 91(6):2076-2084. https://doi.org/10.2/JQUERY.MIN.JS
  36. Pandiar D, Smitha T. The “hallmark” cells. J Oral Maxillofac Pathol. 2019;23(2):176-177.  https://doi.org/10.4103/JOMFP.JOMFP_177_19
  37. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al. eds. World Health Organization (WHO) classification of tumours of haematopoietic and lymphoid tissues. Lyon (France): IARC; 2008.
  38. Stein H, Mason DY, Gerdes J, O’connor N, Wainscoat J, Pallesen G et al. The expression of the Hodgkin’s disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985;66(4):848-858.  https://doi.org/10.1182/BLOOD.V66.4.848.848
  39. Bonzheim I, Geissinger E, Roth S, Zettl A, Marx A, Rosenwald A et al. Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood. 2004;104(10):3358-3360. https://doi.org/10.1182/BLOOD-2004-03-1037
  40. Foss HD, Anagnostopoulos I, Araujo I, Assaf C, Demel G, Kummer JA et al. Anaplastic Large-Cell Lymphomas of T-Cell and Null-Cell Phenotype Express Cytotoxic Molecules. Blood. 1996;88(10):4005-4011. https://doi.org/10.1182/BLOOD.V88.10.4005.BLOODJOURNAL88104005
  41. Krenacs L, Wellmann A, Sorbara L, Himmelmann AW, Bagdi E, Jaffe ES et al. Cytotoxic Cell Antigen Expression in Anaplastic Large Cell Lymphomas of T- and Null-Cell Type and Hodgkin’s Disease: Evidence for Distinct Cellular Origin. Blood. 1997;89(3):980-989. https://doi.org/10.1182/BLOOD.V89.3.980 
  42. Abramov D, Oschlies I, Zimmermann M, Konovalov D, Damm-Welk C, Wössmann W et al. Expression of CD8 is associated with non-common type morphology and outcome in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Haematologica. 2013;98(10):1547-1553. https://doi.org/10.3324/HAEMATOL.2013.085837
  43. Popnikolov NK, Payne DA, Hudnall SD, Hawkins HK, Kumar M, Norris BA et al. CD13-positive anaplastic large cell lymphoma of T-cell origin — a diagnostic and histogenetic problem. Arch Pathol Lab Med. 2000;124(12):1804-1808. https://doi.org/10.5858/2000-124-1804-CPALCL
  44. Sibon D, Nguyen DP, Schmitz N, Suzuki R, Feldman AL, Gressin R et al. ALK-positive anaplastic large-cell lymphoma in adults: an individual patient data pooled analysis of 263 patients. Haematologica. 2019;104(12):e562. https://doi.org/10.3324/HAEMATOL.2018.213512
  45. Seidemann K, Tiemann M, Schrappe M, Yakisan E, Simonitsch I, Janka-Schaub G et al. Short-pulse B — non-Hodgkin lymphoma — type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90. Blood. 2001;97(12):3699-3706. https://doi.org/10.1182/BLOOD.V97.12.3699
  46. Brugières L, Le Deley MC, Rosolen A, Williams D, Horibe K, Wrobel G et al. Impact of the methotrexate administration dose on the need for intrathecal treatment in children and adolescents with anaplastic large-cell lymphoma: results of a randomized trial of the EICNHL Group. J Clin Oncol. 2009;27(6):897-903.  https://doi.org/10.1200/JCO.2008.18.1487
  47. Lowe EJ, Reilly AF, Lim MS, Gross TG, Saguilig L, Barkauskas DA et al. Brentuximab vedotin in combination with chemotherapy for pediatric patients with ALK+ ALCL: results of COG trial ANHL12P1. Blood. 2021;137(26):3595-3603. https://doi.org/10.1182/BLOOD.2020009806
  48. Lowe EJ, Reilly AF, Lim MS, Gross TG, Saguilig L, Barkauskas DA et al. Crizotinib in Combination With Chemotherapy for Pediatric Patients With ALK+ Anaplastic Large-Cell Lymphoma: The Results of Children’s Oncology Group Trial ANHL12P1. J Clin Oncol. 2022;41(11):2043-2053. https://doi.org/10.1200/JCO.22.00272

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.