Clinical experience with retinol oil solution in patients with moderate to severe papulopustular acne

Butareva M.M.; Kobyatskaya E.E.; Metsger A.V.

doi:https://doi.org/10.17116/klinderma202221041479

Butareva M.M.

The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation;
«Beauty Trend»

Kobyatskaya E.E.

The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation

Metsger A.V.

The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation

Clinical experience with retinol oil solution in patients with moderate to severe papulopustular acne

Authors:

Butareva M.M., Kobyatskaya E.E., Metsger A.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2022;21(4): 479‑484

DOI: 10.17116/klinderma202221041479

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To cite this article:

Butareva MM, Kobyatskaya EE, Metsger AV. Clinical experience with retinol oil solution in patients with moderate to severe papulopustular acne. Russian Journal of Clinical Dermatology and Venereology. 2022;21(4):479‑484. (In Russ.)
https://doi.org/10.17116/klinderma202221041479

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

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BACKGROUND

The high cost of isotretinoin agents and the limited availability of imported drugs due to sanctions imposed on Russia require a search for low-cost domestic versions of retinoid agents for acne treatment.

OBJECTIVE

Study of the efficacy and safety of the optimal dose of 3300 IU/kg/day or 1 drop/kg/day in papulopustular acne.

MATERIALS AND METHODS

A prospective clinical trial enrolled 35 patients with papulopustular acne. Patients were treated with this type of retinol ester (dose not exceeding 300.000 IU/day). The core daily skin care products were used as well. Therapy effectiveness was assessed once a month (complaints assessment and skin examination, photographing, assessment of symptoms using CADI, DLQI, and APSEA scores), and the follow-up period was 12 months. Blood chemistry was performed before, during, and after treatment; free retinol blood concentration was measured by gas chromatography-mass spectrometry, and signs of retinoid dermatitis were recorded.

RESULTS

Reduction of skin oiliness and resolution of inflammatory and non-inflammatory elements were noted in all cases. Therapy with this drug was not associated with any serious adverse events. In 5.7% of cases, a slight increase of alanine aminotransferase was reported 3 months after the start of treatment, which did not require discontinuation of the drug. The retinoid dermatitis signs were observed in all cases, indicating the correct dosage used. Free retinol blood levels were measured before, 1 and 6 months after the start of treatment with no abnormal levels detected.

CONCLUSION

Oil solution can be recommended as an effective, safe, and cost-effective treatment option for papulopustular acne.

Keywords:

acne

treatment

retinoid dermatitis

free retinol

Authors:

Butareva M.M.

The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation;
«Beauty Trend»

Kobyatskaya E.E.

The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation

Metsger A.V.

The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation

Received:

05.05.2022

Accepted:

02.06.2022

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References:

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