BACKGROUND
The high cost of isotretinoin agents and the limited availability of imported drugs due to sanctions imposed on Russia require a search for low-cost domestic versions of retinoid agents for acne treatment.
OBJECTIVE
Study of the efficacy and safety of the optimal dose of 3300 IU/kg/day or 1 drop/kg/day in papulopustular acne.
MATERIALS AND METHODS
A prospective clinical trial enrolled 35 patients with papulopustular acne. Patients were treated with this type of retinol ester (dose not exceeding 300.000 IU/day). The core daily skin care products were used as well. Therapy effectiveness was assessed once a month (complaints assessment and skin examination, photographing, assessment of symptoms using CADI, DLQI, and APSEA scores), and the follow-up period was 12 months. Blood chemistry was performed before, during, and after treatment; free retinol blood concentration was measured by gas chromatography-mass spectrometry, and signs of retinoid dermatitis were recorded.
RESULTS
Reduction of skin oiliness and resolution of inflammatory and non-inflammatory elements were noted in all cases. Therapy with this drug was not associated with any serious adverse events. In 5.7% of cases, a slight increase of alanine aminotransferase was reported 3 months after the start of treatment, which did not require discontinuation of the drug. The retinoid dermatitis signs were observed in all cases, indicating the correct dosage used. Free retinol blood levels were measured before, 1 and 6 months after the start of treatment with no abnormal levels detected.
CONCLUSION
Oil solution can be recommended as an effective, safe, and cost-effective treatment option for papulopustular acne.