The analysis of literature data devoted to the problem of the association of atopic dermatitis (AD) with diseases of the digestive system was carried out. The presence of concomitant diseases of the gastrointestinal tract (GIT) is a triggering factor for atopic dermatitis, both in children and adults. The occurrence of AD is associated with a violation of the microecological balance of the intestine, a deficiency of lactobacilli and bifidobacteria, excessive growth of Staphylococcus aureus, E. coli with altered properties. Various studies have revealed a direct correlation between the degree of bacterial contamination of the gastric mucosa with Hp, the activity of chronic gastritis and the severity of arterial hypertension, which was the rationale for including in the plan for examining patients with high blood pressure for the presence of Hp and, if detected, anti-Helicobacter therapy. The article provides data on the development of food tolerance, which includes the ability to tolerate food as a result of the natural process of extinction of the immunopathological reaction to food. The formation of food tolerance, along with a genetic predisposition, is influenced by the composition of the gastrointestinal microflora, the duration of breastfeeding, and the age of the first admission of the «foreign allergen». Based on international and Russian clinical guidelines for the treatment of AD, the place of topical corticosteroid drugs in the therapy of AD was determined. The efficacy and safety of a micronized drug containing methylprednisolone aceponate and ceramides in the treatment of blood pressure has been shown in the wide practice of a dermatovenerologist.