Mechanisms of additivity of physiotherapeutic factors in complex therapy of polypous rhinosinusitis complicated by comorbidities

Pelishenko T.G.; Frolkov V.K.; Nagornev S.N.

doi:https://doi.org/10.17116/rbpdpm202520315

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Frolkov V.K.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-4920-5982

Nagornev S.N.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-1190-1440

Mechanisms of additivity of physiotherapeutic factors in complex therapy of polypous rhinosinusitis complicated by comorbidities

Authors:

Pelishenko T.G., Frolkov V.K., Nagornev S.N.

More about the authors

Journal: Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(3): 5‑11

DOI: 10.17116/rbpdpm202520315

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To cite this article:

Pelishenko TG, Frolkov VK, Nagornev SN. Mechanisms of additivity of physiotherapeutic factors in complex therapy of polypous rhinosinusitis complicated by comorbidities. Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2025;2(3):5‑11. (In Russ.)
https://doi.org/10.17116/rbpdpm202520315

Подписка 2026 Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина (Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine)

Использование инфографики авторами научных работ

OBJECTIVE

To analyze the features of various physiotherapeutic complexes in the treatment of polypous rhinosinusitis, including those complicated by bronchial asthma and atopic dermatitis, by using the ideas of V.S. Ulashchik.

MATERIAL AND METHODS

The study included 90 patients with isolated polypous rhinosinusitis, as well as associated bronchial asthma (88 patients) and atopic dermatitis (67 patients). All patients received basic therapy and dupilumab (control group). Alternating magnetic field and low-intensity infrared laser were additionally used for polyposis rhinosinusitis. Bronchial asthma required additional interval hypoxia training, atopic dermatitis — phototherapy. All examinations were conducted before and 6 months after completion of each preventive course.

RESULTS

Favorable dynamics of clinical and biochemical markers of disease in case of combined physiotherapy for isolated polyposis rhinosinusitis averaged 51.1+1.45%, in concomitant bronchial asthma — 37.6+1.03%, atopic dermatitis — 60.6+2.82%. Synergism of therapeutic effects of combined physiotherapy for isolated polyposis rhinosinusitis was additive, in combination with bronchial asthma — subadditive, in combination with atopic dermatitis — superadditive.

CONCLUSION

Our results allow us to assess the mechanisms of additivity of various preformed physical factors using coefficient of synergism. This can underlie new effective methods of combined physiotherapy for somatic diseases with emphasis on superadditive (mutually potentiating) combination of biological potential of each factor.

Keywords:

polypous rhinosinusitis

comorbid diseases

bronchial asthma

atopic dermatitis

combined physiotherapy

synergism coefficient

Authors:

Pelishenko T.G.

Clinical Hospital No. 1 of the Presidential Administration

ORCID: 0000-0001-6597-2167

Frolkov V.K.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-4920-5982

Nagornev S.N.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-1190-1440

Received:

10.06.2025

Accepted:

11.07.2025

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References:

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