Atopic dermatitis is one of the most common chronic inflammatory skin diseases occurring in representatives of both sexes worldwide and in different age groups. Dermatitis pathogenesis is based on skin inflammation caused by Th2 cells activation that is accompanied by increase of its sensitivity to irritative agents. Interleukin-33 is involved in Th2 cytokines formation that may indicate its role in the atopic dermatitis pathogenesis.

OBJECTIVE

To evaluate IL-33 level in patients with atopic dermatitis and disease course severity depending on its level.

MATERIAL AND METHODS

The study involved 20 patients with clinically diagnosed dermatitis. Patients with autoimmune diseases, such as psoriasis, vitiligo, urticaria were excluded according to the Hanifin-Rajka criteria, as these diseases could increase IL-33 level in the blood. The group involving 10 patients without this disease was also created. The patients were divided into 3 groups depending on severity on the EASI. Blood samples were taken in all participants.

RESULTS

There has been a high statistical difference in the serum IL-33 level between groups of patients and control group. In addition, the interleukins level can be used to determine the atopic dermatitis severity.

CONCLUSION

Patients with atopic dermatitis had an increased level of IL-33. Therefore, IL-33 still plays a direct role in this pathology development regardless of sex and family history, and its level determination in the blood serum can be used to differentiate the atopic dermatitis severity: mild, moderate and severe.