The content of the antimicrobial peptide cathelicidin LL-37 and bacteriological profile of the skin in a plaque, exudative and pustular psoriasis

Bakhlykova E.A.; Filimonkova N.N.; Matusevich S.L.; Karmatskikh O.G.; Gwavy P.N.

doi:https://doi.org/10.17116/klinderma20212001133

Bakhlykova E.A.

Tyumen State Medical University

Filimonkova N.N.

Ural Research Institute of Dermatovenereology and Immunopathology

Matusevich S.L.

Tyumen State Medical University

Karmatskikh O.G.

Medical laboratory «Quality Med»

Gwavy P.N.

Regional Dermatovenerologic Clinic

The content of the antimicrobial peptide cathelicidin LL-37 and bacteriological profile of the skin in a plaque, exudative and pustular psoriasis

Authors:

Bakhlykova E.A., Filimonkova N.N., Matusevich S.L., Karmatskikh O.G., Gwavy P.N.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2021;20(1): 33‑39

DOI: 10.17116/klinderma20212001133

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To cite this article:

Bakhlykova EA, Filimonkova NN, Matusevich SL, Karmatskikh OG, Gwavy PN. The content of the antimicrobial peptide cathelicidin LL-37 and bacteriological profile of the skin in a plaque, exudative and pustular psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2021;20(1):33‑39. (In Russ.)
https://doi.org/10.17116/klinderma20212001133

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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ACTUALIZATION

The process of psoriatic inflammation is possibly caused by the activation of the immune response to pathogens of the skin microbiota by means of antimicrobial peptides — microbiome regulators at the level of skin barriers.

OBJECTIVE

To study the bacterial profile of the surface of psoriatic lesions and the level of the antimicrobial peptide cathelicidin LL-37 in the blood serum of patients with various forms of psoriasis compared with healthy individuals.

MATERIAL AND METHODS

The study included patients with exudative (EP, n=24), plaque (PD, n=32), palmar-plantar pustular (PPPP, n=18) psoriasis and healthy individuals (HP, n=20). The patients underwent a microbiological examination of the skin in the area of plaques by mass spectrometry using the MALDI-TOF microorganism identification technology; determination of the content of cathelicidin LL-37 by enzyme immunoassay in the blood serum of patients.

RESULTS

As a result of the study, various patterns of microorganisms were identified from the surface of psoriatic elements. On the basis of bacteriological research from the surface of psoriatic elements, S. aureus was more often detected in EP (50%), PP (24.2%), PPPP (16.6%), HP (10%); S. epidermidis was detected in PPPP (33.3%), EP (16.6%), PP (14.5%), HP (15%). The level of catelicidin LL-37 in blood serum was increased (p<0.05) in patients with PP (2.6±0.2 ng/ml) and PPPP (2.9±0.3 ng/ml) compared to HP (1.56±0.2 ng/ml), in the EP group (4.0±0.1 ng/ml) was determined significantly higher than in the groups of PPPP, PP, and HP (p<0.05).

CONCLUSION

The study revealed a higher content of bacteria on the surface of psoriatic lesions in patients with various forms of psoriasis, especially in patients with exudative psoriasis, than on the skin of healthy individuals. Identification of microbiota patterns in various clinical forms of psoriasis suggests a possible role of infection in the initiation and development of immune inflammation in psoriasis. Increased serum level of catelicidin LL-37 indicate its pathogenetic value in psoriasis as a significant factor of innate immunity.

Keywords:

psoriasis

antimicrobial peptides

cathelicidin LL-37

microbiota

Authors:

Bakhlykova E.A.

Tyumen State Medical University

Filimonkova N.N.

Ural Research Institute of Dermatovenereology and Immunopathology

Matusevich S.L.

Tyumen State Medical University

Karmatskikh O.G.

Medical laboratory «Quality Med»

Gwavy P.N.

Regional Dermatovenerologic Clinic

Received:

03.06.2020

Accepted:

11.12.2020

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