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Avseenko M.A.

Ural Research Institute for Maternal and Child Health

Melkozerova O.A.

Ural Research Institute for Maternity and Child Care, Ministry of Public Health of the Russian Federation

Semenov Yu.A.

Ural Scientific Research Institute of Maternity and Child Care

Mikhelson A.A.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Braslavskaya E.P.

Ural Scientific Research Institute of Maternity and Child Care

Timerkhanova E.O.

Ural Research Institute for Maternal and Child Health

Influence of carriage of papillomavirus infection on the course of external genital endometriosis in patients with intraepithelial lesion of the cervix

Authors:

Avseenko M.A., Melkozerova O.A., Semenov Yu.A., Mikhelson A.A., Braslavskaya E.P., Timerkhanova E.O.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(3): 77‑83

DOI: 10.17116/repro20253103177

Read: 1476 times

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Table of contents

INFLUENCE OF CARRIAGE OF PAPILLOMAVIRUS INFECTION ON THE COURSE OF EXTERNAL GENITAL ENDOMETRIOSIS IN PATIENTS WITH INTRAEPITHELIAL LESION OF THE CERVIX
INFLUENCE OF CARRIAGE OF PAPILLOMAVIRUS INFECTION ON THE COURSE OF EXTERNAL GENITAL ENDOMETRIOSIS IN PATIENTS WITH INTRAEPITHELIAL LESION OF THE CERVIX

To cite this article:

Avseenko MA, Melkozerova OA, Semenov YuA, Mikhelson AA, Braslavskaya EP, Timerkhanova EO. Influence of carriage of papillomavirus infection on the course of external genital endometriosis in patients with intraepithelial lesion of the cervix. Russian Journal of Human Reproduction. 2025;31(3):77‑83. (In Russ.)
https://doi.org/10.17116/repro20253103177

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review analyzes the data of systematic reviews and randomized clinical trials devoted to the features of the course of external genital endometriosis in women with cervical intraepithelial neoplasia against the background of human papillomavirus carriage. Publications of the PubMed, Medline, CrossRef databases in the range of 2016-2024 were analyzed. The article considers the impact of HPV carriage and disturbance of the intestinal and urogenital tract microbiota on the progression and recurrence of diseases. Modern data on possible tactics of managing patients with combined proliferative pathology are presented. The results of the scientific search convincingly demonstrate the need for further research aimed at finding criteria for personalizing treatment tactics to prevent recurrence of diseases.

Keywords:

genital endometriosis
cervical intraepithelial neoplasia
human papillomavirus
microbiota
relapse
reproductive age
infertility

Authors:

Avseenko M.A.

Ural Research Institute for Maternal and Child Health

Melkozerova O.A.

Ural Research Institute for Maternity and Child Care, Ministry of Public Health of the Russian Federation

Semenov Yu.A.

Ural Scientific Research Institute of Maternity and Child Care

Mikhelson A.A.

Ural Scientific Research Institute of Maternity and Child Care Public Health’s Ministry of the Russian Federation

Braslavskaya E.P.

Ural Scientific Research Institute of Maternity and Child Care

Timerkhanova E.O.

Ural Research Institute for Maternal and Child Health

Received:

08.08.2024

Accepted:

12.11.2024

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References:

  1. Endometrioz. Klinicheskie rekomendatsii. 2024. Odobreno Nauchno-prakticheskim Sovetom Ministerstva zdravookhraneniya Rossijskoj Federatsii. (In Russ.). Accessed May 08, 2025. https://cr.minzdrav.gov.ru/view-cr/259_2
  2. Safronova AS, Buralkina NA, Burduli AG, Arakelyan AS, Chuprynin VD, Adamyan LV. Reproductive potential of patients with various forms of endometriosis (literature review). Russian Journal of Human Reproduction. 2021;27(1):24-32. (In Russ.). https://doi.org/10.17116/repro20212701124
  3. Zondervan KT, Becker CM, Missmer SA. Endometriosis. New England Journal of Medicine. 2020;382(13):1244-1256. https://doi.org/10.1056/NEJMra1810764
  4. Smolarz B, Szyłło K, Romanowicz H. Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature). International Journal of Molecular Sciences. 2021;22(19):10554. https://doi.org/10.3390/ijms221910554
  5. Zhang L, Li H, Yuan M, Li D, Sun C, Wang G. Serum Exosomal MicroR-NAs as Potential Circulating Biomarkers for Endometriosis. Disease Markers. 2020:2456340. https://doi.org/10.1155/2020/2456340
  6. Lamceva J, Uljanovs R, Strumfa I. The Main Theories on the Pathogenesis of Endometriosis. International Journal of Molecular Sciences. 2023;24(5):4254. https://doi.org/10.3390/ijms24054254
  7. Aints A, Mölder S, Salumets A. EXTL3-interacting endometriosis-specific serum factors induce colony formation of endometrial stromal cells. Scientific Reports. 2019;9(1):12562. https://doi.org/10.1038/s41598-019-48840-8
  8. Ianieri MM, Mautone D, Ceccaroni M. Recurrence in deep infiltrating endometriosis: A systematic review of the literature. Journal of Minimally Invasive Gynecology. 2018;25(5):786-793.  https://doi.org/10.1016/j.jmig.2017.12.025
  9. Nirgianakis K, Ma L, McKinnon B, Mueller MD. Recurrence Patterns after Surgery in Patients with Different Endometriosis Subtypes: A Long-Term Hospital-Based Cohort Study. Journal of Clinical Medicine. 2020;9(2):496.  https://doi.org/10.3390/jcm9020496
  10. Song SY, Jung YW, Shin W, Park M, Lee GW, Jeong S, An S, Kim K, Ko YB, Lee KH, Kang BH, Lee M, Yoo HJ. Endometriosis-Related Chronic Pelvic Pain. Biomedicines. 2023;11(10):2868. https://doi.org/10.3390/biomedicines11102868
  11. Horne AW, Daniels J, Hummelshoj L, Cox E, Cooper KG. Surgical removal of superficial peritoneal endometriosis for managing women with chronic pelvic pain: time for a rethink? BJOG: An International Journal of Obstetrics and Gynaecology. 2019;126(12):1414-1416. https://doi.org/10.1111/1471-0528.15894
  12. Orazov MR, Radzinsky VE, Orekhov RE. The effectiveness of therapy for endometriosis-associated pelvic pain resistant to surgical treatment. Ginekologiya. 2021;23(4):314-323. (In Russ.). https://doi.org/10.26442/20795696.2021.4.201097
  13. Zakhari A, Delpero E, McKeown S, Tomlinson G, Bougie O, Murji A. Endometriosis recurrence following post-operative hormonal suppression: a systematic review and meta-analysis. Human Reproduction Update . 2021;27(1):96-107.  https://doi.org/10.1093/humupd/dmaa033
  14. Guo S-W, Martin DC. The perioperative period: a critical yet neglected time window for reducing the recurrence risk of endometriosis. Human Reproduction. 2019;34(10):1858-1865. https://doi.org/10.1093/humrep/dez187
  15. Guo S.W. Recurrence of endometriosis and its control. Human Reproduction. 2009;15(4):441-461.  https://doi.org/10.1093/humupd/dmp007
  16. Tservikal’naya intraepitelial’naya neoplasiya, eroziya i ektropion shejki matki. Klinicheskie rekomendatsii. 2024. Odobreno Nauchno-prakticheskim Sovetom Ministerstva zdravookhraneniya Rossijskoj Federatsii. (In Russ.). Accessed May 08, 2025. https://cr.minzdrav.gov.ru/view-cr/597_3
  17. Kachalina OV, Korenkova AA. Cervical endometriosis — possibilities for solving the problem. Meditsinskij sovet. 2018;21:174-177. (In Russ.). https://doi.org/10.21518/2079-701X-2018-21-174-177
  18. Moslehi Z, Derakhshan R, Chaichian S, Mehdizadeh Kashi A, Sabet B, Rokhgireh S. Correlation of High-Risk Human Papilloma Virus with Deep Endometriosis: A Cross-Sectional Study. Biomed Research International. 2023;2023:6793898. https://doi.org/10.1155/2023/6793898
  19. Suhaila K, Mukherjee A, Maharjan B, Dhakal A, Lama M, Junkins A, Khakurel U, Jha AN, Jolly PE, Lhaki P, Shrestha S. Human Papillomavirus, Related Diseases, and Vaccination: Knowledge and Awareness Among Health Care Students and Professionals in Nepal. Journal of Cancer Education. 2022;37:1727-1735. https://doi.org/10.1007/s13187-021-02018-x
  20. Georgescu SR, Mitran CI, Mitran MI, Caruntu C, Sarbu MI, Matei C, Nicolae I, Tocut SM, Popa MI, Tampa M. New Insights in the Pathogenesis of HPV Infection and the Associated Carcinogenic Processes: The Role of Chronic Inflammation and Oxidative Stress. Journal of Immunology Research. 2018;18:5315816. https://doi.org/10.1155/2018/5315816
  21. Guillemot C, Klinkenberg J, Sordes F. Vécu psychologique de la sexualité chez les patientes endométriosiques douloureuses. Psychologie Française. 2023;68(3):345-358.  https://doi.org/10.1016/j.psfr.2023.04.002
  22. Shigesi N, Kvaskoff M, Kirtley S, Feng Q, Fang H, Knight JC, Missmer SA, Rahmioglu N, Zondervan KT, Becker CM. The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis. Human Reproduction Update. 2019; 25(4):486-503.  https://doi.org/10.1093/humupd/dmz014
  23. Chen S, Liu Y, Zhong Z, Wei C, Liu Y, Zhu X. Peritoneal immune microenvironment of endometriosis: Role and therapeutic perspectives. Frontiers Immunology. 2023;14:1134663. https://doi.org/10.3389/fimmu.2023.1134663
  24. Vestergaard AL, Knudsen UB, Munk T, Rosbach H, Bialasiewicz S, Sloots TP, Martensen PM, Antonsson A. Low prevalence of DNA viruses in the human endometrium and endometriosis. Archives of Virology. 2010;155(5):695-703.  https://doi.org/10.1007/s00705-010-0643-y
  25. De Oliveira GG, Eleutério J, Eleutério R. HPV infection and endometriosis: a systematic review and meta-analysis. Jornal Brasileiro de Doenças Sexualmente Transmissíveis. 2019 Jan;31(4):138-142.  https://doi.org/10.5327/DST-2177-8264-20203205
  26. Heidarpour M, Derakhshan M, Derakhshan-Horeh M, Kheirollahi M, Dashti S. Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis. Journal of Obstetrics Gynaecology Research. 2017;43(1):135-139.  https://doi.org/10.1111/jog.13188
  27. Okyay E, Kula H, Yavuz O, Akdoner A, Cagliyan E. The Human Papillomavirus and Its Relationship to Infertility and Endometriosis. Clinical and Experimental Obstetrics and Gynecology. 2023;50(8):170.  https://doi.org/10.31083/j.ceog5008170
  28. Ding L, Liu C, Zhou Q, Feng M, Wang J: Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma. Oncology Letters. 2019;17:3548-3554. https://doi.org/10.3892/ol.2019.10005
  29. Klyukina LA, Sosnova EA, Ishchenko AA. The role of combined oral contraceptives in the genesis of the formation of cervical intraepithelial neoplasia associated with the human papillomavirus. Akusherstvo i ginekologiya. 2021;12:102-109. (In Russ.). https://doi.org/10.18565/aig.2021.12.102-109
  30. Hong YS, Park J, Kim H. Association of endometriosis with genital human papillomavirus infection in US women: a national population-based study. Scientific Reports. 2023;13(1):8020. https://doi.org/10.1038/s41598-023-35153-0
  31. Rocha RM, Souza RP, Gimenes F, Consolaro MEL. The high-risk human papillomavirus continuum along the female reproductive tract and its relationship to infertility and endometriosis. Reproductive Biomedicine Online. 2019;38:926-937.  https://doi.org/10.1016/j.rbmo.2018.11.032
  32. Jimenez N, Norton T, Diadala G, Bell E, Valenti M, Farland LV, Mahnert N, Herbst-Kralovetz MM. Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain. BMC Medicine. 2024;22(1):283.  https://doi.org/10.1186/s12916-024-03500-1
  33. Saidi K, Sharma S, Ohlsson B. A systematic review and meta-analysis of the associations between endometriosis and irritable bowel syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2020;246:99-105.  https://doi.org/10.1016/j.ejogrb.2020.01.031
  34. Pickard JM, Zeng MY, Caruso R, Núñez G. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological Reviews. 2017;279(1):70-89.  https://doi.org/10.1111/imr.12567
  35. Jiang I, Yong PJ, Allaire C, Bedaiwy MA. Intricate Connections between the Microbiota and Endometriosis. International Journal of Molecular Sciences. 2021;22:5644. https://doi.org/10.3390/ijms22115644
  36. Brichant G, Laraki I, Henry L, Munaut C, Nisolle M. New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments. International Journal of Molecular Sciences. 2021;22(19):10498. https://doi.org/10.3390/ijms221910498
  37. Huang L, Liu B, Liu Z, Feng W, Liu M, Wang Y, Peng D, Fu X, Zhu H, Cui Z, Xie L, Ma Y. Gut microbiota exceeds cervical microbiota for early diagnosis of endometriosis. Frontiers in Cellular and Infection Microbiology. 2021;11:788836. https://doi.org/10.3389/fcimb.2021.788836
  38. Khan KN, Fujishita A, Hiraki K, Kitajima M, Nakashima M, Fushiki S, Kitawaki J. Bacterial contamination hypothesis: a new concept in endometriosis. Reproductive Medicine and Biology. 2018;17(2):125-133.  https://doi.org/10.1002/rmb2.12083
  39. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2016;336(6086): 1268-1273. https://doi.org/10.1126/science.1223490
  40. Hantschel J, Weis S, Schäfer KH, Menger MD, Kohl M, Egert M, Laschke MW. Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation. PLoS One. 2019;14(12):e0226835. https://doi.org/10.1371/journal.pone.0226835
  41. Shan J, Ni Z, Cheng W, Zhou L, Zhai D, Sun S, Yu C. Gut micro- biota imbalance and its correlations with hormone and inflammatory factors in patients with stage III-IV endometriosis. Archives of Gynecology and Obstetrics. 2021;304(5):1363-1373. https://doi.org/10.1007/s00404-021-06057-z
  42. Salliss ME, Farland LV, Mahnert ND, Herbst-Kralovetz MM. The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain. Human Reproduction Update. 2021;28(1):92-131.  https://doi.org/10.1093/humupd/dmab035
  43. Ata B, Yildiz S, Turkgeldi E, Brocal VP, Dinleyici EC, Moya A, Urman B. The Endobiota Study: Comparison of vaginal, cervical and gut microbiota between women with stage III-IV endometriosis and healthy controls. Scientific Reports. 2019;9(1):2204. https://doi.org/10.1038/s41598-019-39700-6
  44. Gardella B, Pasquali MF, La Verde M, Cianci S, Torella M, Dominoni M. The Complex Interplay between Vaginal Microbiota, HPV Infection, and Immunological Microenvironment in Cervical Intraepithelial Neoplasia: A Literature Review. International Journal of Molecular Sciences. 2022;23(13):7174. https://doi.org/10.3390/ijms23137174
  45. Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N. The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis. BJOG: An International Journal of Obstetrics and Gynaecology. 2020; 127(2):171-180.  https://doi.org/10.1111/1471-0528.15854
  46. Caselli E, D’Accolti M, Santi E, Soffritti I, Conzadori S, Mazzacane S, Greco P, Contini C, Bonaccorsi G. Vaginal Microbiota and Cytokine Microenvironment in HPV Clearance/Persistence in Women Surgically Treated for Cervical Intraepithelial Neoplasia: An Observational Prospective Study. Frontiers in Cellular and Infection Microbiology. 2020;10:540900. https://doi.org/10.3389/fcimb.2020.540900
  47. Istmiko-tservikal’naya nedostatochnost’. Klinicheskie rekomendatsii. 2024. Odobreno Nauchno-prakticheskim Sovetom Ministerstva zdravookhraneniya Rossijskoj Federatsii. (In Russ.). Accessed May 08, 2024. https://cr.minzdrav.gov.ru/view-cr/671_2
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