Diagnostic significance of the gut microbiota and its metabolites in cardiovascular risk assessment among patients with ulcerative colitis

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OBJECTIVE

: To evaluate the diagnostic value of markers characterizing gut microbiota metabolism and intestinal permeability in UC patients in the context of arterial hypertension (AH) risk.

MATERIALS AND METHODS

The study included 80 UC patients divided into two groups: those with UC and AH (Group 1) and those without AH (Group 2). TMAO levels in blood, zonulin, and short-chain fatty acids (SCFAs) in stool were assessed. Quantitative features with an alternative distribution were described using the median (Me), upper, and lower quartiles (P25, P75). The Mann-Whitney test and Bayesian approach were applied to evaluate diagnostic significance.

RESULTS

A significant increase in TMAO (1473.4 ng/mL vs. 785.02 ng/mL, p=0.01) and zonulin levels (318.42 ng/g vs. 164.22 ng/g, p=0.039) was observed in Group 1. Reduced acetic acid levels and anaerobic index were noted in the AH group, indicating gut microbiota imbalance.

CONCLUSION

UC is a systemic inflammatory disease associated with an increased risk of CVDs. Investigating gut microbiota and its metabolites provides new opportunities for the prevention and treatment of cardiovascular complications in UC patients.

Keywords:

ulcerative colitis

microbiota

fecal zonulin

short-chain fatty acids

trimethylamine N-oxide

Authors:

Bikbavova G.R.

Omsk State Medical University

ORCID: 0000-0001-9252-9152

Livzan M.A.

Omsk State Medical University

ORCID: 0000-0002-6581-7017

Turchaninov D.V.

Omsk State Medical University

ORCID: 0000-0002-6298-4872

Lisyutenko N.S.

Omsk State Medical University

ORCID: 0000-0003-4088-240X

Romanyuk A.E.

Omsk State Medical University

ORCID: 0000-0001-6308-4377

Mashnin M.Yu.

Omsk State Medical University

ORCID: 0009-0007-8493-3690

Received:

14.10.2024

Accepted:

19.11.2024

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Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST). Accessed September 10, 2024. https://clinicaltrials.gov/study/NCT03556384

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Chi P, Qin LX, Nguyen B, Kelly CM, D’Angelo SP, Dickson MA, Gounder MM, Keohan ML, Movva S, Nacev BA, Rosenbaum E, Thornton KA, Crago AM, Yoon S, Ulaner G, Yeh R, Martindale M, Phelan HT, Biniakewitz MD, Warda S, Lee CJ, Berger MF, Schultz ND, Singer S, Hwang S, Chen Y, Antonescu CR, Tap WD. Phase II Trial of Imatinib Plus Binimetinib in Patients With Treatment-Naive Advanced Gastrointestinal Stromal Tumor. Journal of Clinical Oncology. 2022;40(9):997-1008. https://doi.org/10.1200/JCO.21.02029

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Joensuu H, Blay JY, Comandone A, Martin-Broto J, Fumagalli E, Grignani G, Del Muro XG, Adenis A, Valverde C, Pousa AL, Bouché O, Italiano A, Bauer S, Barone C, Weiss C, Crippa S, Camozzi M, Castellana R, Le Cesne A. Dovitinib in patients with gastrointestinal stromal tumour refractory and/or intolerant to imatinib. British Journal of Cancer. 2017;117(9):1278-1285. https://doi.org/10.1038/bjc.2017.290

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A phase 1, multicenter, open-label, first-in-human study of DS-6157a in patients (pts) with advanced gastrointestinal stromal tumor (GIST). Accessed September 10, 2024. https://meetings.asco.org/abstracts-presentations/208008

DS-6157a in Participants with Advanced Gastrointestinal Stromal Tumor (GIST). Accessed September 10, 2024. https://clinicaltrials.gov/ct2/show/NCT04276415

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