The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Sokolova T.V.

Medical Institute of Continuing Education of the Federal State Budgetary Institution of Higher Education «Moscow State University of Food Production»

Davidenko M.S.

Medical Institute of Continuing Education of the Moscow State University of Food Production

Menshikova A.I.

Institute of Medicine, Ecology and Physical Culture of the Ulyanovsk State University

Atopic dermatitis: the use of antihistamines for children in outpatient clinical practice

Authors:

Sokolova T.V., Davidenko M.S., Menshikova A.I.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(5): 701‑710

DOI: 10.17116/klinderma202019051701

Read: 15092 times

Contact the author
Table of contents

ATOPIC DERMATITIS: THE USE OF ANTIHISTAMINES FOR CHILDREN IN OUTPATIENT CLINICAL PRACTICE
ATOPIC DERMATITIS: THE USE OF ANTIHISTAMINES FOR CHILDREN IN OUTPATIENT CLINICAL PRACTICE

To cite this article:

Sokolova TV, Davidenko MS, Menshikova AI. Atopic dermatitis: the use of antihistamines for children in outpatient clinical practice. Russian Journal of Clinical Dermatology and Venereology. 2020;19(5):701‑710. (In Russ.)
https://doi.org/10.17116/klinderma202019051701

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Gene­sis of emollients. Past, present, future. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):412-420
From atopy to infe­ction — a clinical case of combined skin pathology. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):430-436
Atopic dermatitis: the problem of adhe­rence to emollients. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(5):698-707
Issues of diagnosis and treatment of atopic dermatitis. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(6):838-845
Asse­ssment of psychological trauma in patients with atopic dermatitis. Russian Journal of Clinical Dermatology and Vene­reology. 2026;(1):47-52
Alopecia areata morbidity stru­cture considering the asso­ciation with atopic dermatitis in the popu­lation of Moscow in comparison with data from the fede­ral regi­ster. Russian Journal of Clinical Dermatology and Vene­reology. 2026;(2):169-177
Mechanisms of addi­tivity of physiotherapeutic factors in complex therapy of poly­pous rhinosinusitis complicated by como­rbidities. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2025;(3):5-11
Sleep diso­rders and the course of atopic dermatitis in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(5-2):105-109
Features of the microbial landscape of the skin of patients with atopic dermatitis during exacerbation and in the remi­ssion phase. Journal of Adaptive Medi­cal Immu­nology and Public Health Issues. 2026;(1):60-66
Stress as an inte­rdisciplinary problem in the clinic of immuno-dependent diseases. Journal of Adaptive Medi­cal Immu­nology and Public Health Issues. 2026;(1):71-77
Abstract:

RELEVANCE

Currently, clinical pharmacologists focus on the correct use of various drugs for the treatment of patients. The main document authorizing the use of drugs in Russia is the State Register of Medicines (SRM). Information about the drug is described in the manufacturer’s instructions. The main document defining the tactics of treating patients with atopic dermatitis (AtD) are the Federal Clinical Recommendations (FCR). Assessing the correctness of the choice of drugs for the treatment of AtD by doctors is aimed at eliminating the shortcomings.

OBJECTIVE

Evaluation by the method of retrospective analysis of outpatient cards till 2017—2019 years the real using by dermatologists of AGP for the treatment of AtD of children and teenagers.

MATERIAL AND METHODS

The analysis of the SRM and the instructions of the manufacturers of AGP registered in Russia is carried out. A retrospective analysis of 251 outpatient cards of children and teenagers with AtD is performed. The author’s version of the «Individual Registration Card» was used. For statistical processing of the research results, the Pearson criterion (χ2) was used.

RESULTS

Discrepancies detected in SRM and FCR of the Russian Society of Dermatovenerologists and Cosmetologists (2015). A retrospective analysis of the outpatient cards of patients with AtD indicates the presence of serious violations in the appointment of AGP by doctors in clinical practice. With a mild severity, practically all patients were unreasonably prescribed non-recommended of state register of medicines data about AGP of 1 and 2 generations. With a mild severity, AGP of 1 (91.4%) and 2 (94.8%) generations was unreasonably prescribed to almost all patients. With moderate severity of AtD in violation of state register of medicines data, 2 generations of AGP were used more often than 1. Age-related disorders were recorded in 2.6% of cases for 4 drugs. Of the 8 AGP of 2 generations, only 3 are allowed for the treatment of AtD (levocetirizine, loratadine and cetirizine). Doctors mistakenly prescribed another 5 drugs recommended for the treatment of allergic rhinitis/conjunctivitis. The correct choice of AGP of the 2nd generation in AD with an «atopic march» was registered in only 54.4% of patients.

CONCLUSION

The analysis of AGP registered in SRM, the study of instructions of manufacturers firms revealed some inconsistencies between SRM and FCR of the Russian Society of Dermatovenerologists and Cosmetologists (2015) and serious violations in their appointment by doctors in clinical outpatient practice found. The elimination of the identified deficiencies is one of the directions for improving the treatment of AtD.

Keywords:

atopic dermatitis
antihistamines
doctors mistake

Authors:

Sokolova T.V.

Medical Institute of Continuing Education of the Federal State Budgetary Institution of Higher Education «Moscow State University of Food Production»

Davidenko M.S.

Medical Institute of Continuing Education of the Moscow State University of Food Production

Menshikova A.I.

Institute of Medicine, Ecology and Physical Culture of the Ulyanovsk State University

Received:

05.02.2020

Accepted:

06.08.2020

Close metadata

References:

  1. Sepiashvili RI, Slavyanskaya TA. Spectrum and prevalence of allergic diseases in the Commonwealth of Independent States (CIS) Countries. International J Immunorehabilitation. 2011;13(2):123-126. 
  2. Slavyanskaya TA. Spectrum and features of the course of allergic diseases in the CIS countries. «Allergy, Asthma & Immunology: from genes to clinical application». Ed. Revaz Sepiashvili. MEDIMOND International Proceedings. 2011;33-36. 
  3. Mallola J, Craneb E, von Mutiusc J, Odhiambod U, Keile A Stewart F. The ISAAC Phase Three Study Group The International Study of Asthma and Allergies in Childhood (ISAAC): A global synthesiseceived. 2012;56. 
  4. Guidelines «Organization of specialized medical care for children with atopic dermatitis». Collective authors: NV Kungurov, NP Toropova, NP Malishevskaya, NV Silberberg, VA Iglikov, PhD YV Keniksfest, et al. Yekaterinburg. 2011. (In Russ.).
  5. Pankratova EV. Objectification of the diagnosis of atopic dermatitis of men of military age, taking into account the analysis of the incidence: Dis. ... kand. med. nauk. M. 2010. (In Russ.).
  6. Kokhan MM, Samtsov AV, Perlamutrov YN, Sokolovsky EV. Analysis of the methods of external therapy of common dermatoses in the provision of specialized medical care in the profile «Dermatovenerology». Bulletin of Dermatology and Venereology. 2016;6:79-93. (In Russ.).
  7. Sokolova TV, Davidenko MS. Statistics on the prevalence and incidence of atopic dermatitis of children and teenagers: pros and cons. Immunopathology, allergology, infectology. 2019;1:80-88. (In Russ.).
  8. Yarilina LG, Fedenko ES, Latysheva TV. Etiology and pathogenesis of atopic dermatitis. M.: Materia Medica; 2000;25(1):3-18. (In Russ.).
  9. Volkova EN. Atopic dermatitis. Therapist. 2006;9:23-29. (In Russ.).
  10. Current treatment strategy for atopic dermatitis: the pediatrician action program. Conciliation document: Association of Children’s Allergologists and Immunologists of Russia. M. 2006. (In Russ.).
  11. Russian scientific and practical program «Atopic dermatitis of children.» M. 2008. (In Russ.).
  12. Resources and activities of medical organizations of a dermatovenerological profile. The incidence of STIs, infectious skin diseases and skin diseases for 2015—2016. M. 2017. (In Russ.).
  13. Keniksfest YV. The state of specialized medical care for children and teenagers with atopic dermatitis. Ural Medical Journal. 2011;86(8):7-28. (In Russ.).
  14. State program «Health Care Development». Approved by the Government on December 26 in 2017 year №1640. (In Russ.).
  15. Order of the Ministry of Health of the Russian Federation dated on May 10 in 2017 year №203n «On the approval of criteria for assessing the quality of medical care». (In Russ.).
  16. Order of the Ministry of Health of the Russian Federation «On approval of the requirements for organizing and conducting internal control of the quality and safety of medical activity» №381n dated on June 7 in 2019 year. (In Russ.).
  17. Lepakhin VK, Ushkalova EA, Astakhova AV. The role of the clinical pharmacologist in improving the safety of drug therapy. Drug safety and pharmacovigilance. 2008;1:4-10. (In Russ.).
  18. Roszdravnadzor creates a pharmacovigilance service that meets international standards. Drug safety and pharmacovigilance. 2008;1:3. (In Russ.).
  19. Lombardi TP, Kennicutt JD. Promotion of a Safe Medication Environment: Focus on the Elderly and Residents of Long-term Care Facilities. Medscape Pharmacists. 2001;2(1):34-40. 
  20. Rupp MT, Lombardi TP. Value of Community Pharmacists’ Interventions to Correct Prescribing Errors. Annals of Pharmacotherapy. 1992;26:1580-1584.
  21. Rodriguez-Monguio R, Otero M, Rovira J. Assessing the economic impact of adverse drug effects. Pharmacoeconomics. 2003;21(9):623-650. 
  22. Leape LL, Brennan TA, Laird N et al. The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II. N. Engl J Med. 1991;324:377-384. 
  23. Kubanova AA, Proshutinskaya DV, Tekucheva LV, Avdienko IN. The integrated approach to external therapy of atopic dermatitis. Bulletin of Dermatology and Venereology. 2010;1:20-26. (In Russ.).
  24. Grillo M, Gassner L, Marshman G, et al. Pediatric Atopic Eczema: The Impact of an Education Intervention. Pediatric Dermatol. 2006;23(5):428-436. 
  25. Federal clinical guidelines. Dermatovenereology 2015: Skin diseases, sexually transmitted infections. 5th edition, revised and supplemented. M.: Business Express; 2016;39-76. (In Russ.).
  26. Clinical recommendations «Atopic dermatitis of children» of the Union of Pediatricians of Russia, the Russian Association of Allergologists and Clinical Immunologists, the Russian Society of Dermatovenerologists and Cosmetologists M. 2016. (In Russ.).
  27. European guidelines for the treatment of atopic dermatitis of adults and children: part II. 2018. (In Russ.). https://doi.org/10.1111/jdv.14888
  28. Clinical Pharmacology. National Guide. Ed. Belousov Y.B., Kukes V.G., Lepakhin V.K., Petrov V.I. M.: GEOTAR-Media; 2014. (In Russ.).
  29. Luss LV, Ilyina NI. Antihistamines in General Clinical Practice: Questions and Answers. To help a practitioner. 2017;84. (In Russ.).
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.