Treatment efficacy and adherence in patients with chronic heart failure according to the chronic heart failure registry in the Tyumen region

Airapetyan AA, Mezhonov EM, Reitblat OM, et al. Treatment efficacy and adherence in patients with chronic heart failure according to the chronic heart failure registry in the Tyumen region. Russian Cardiology Bulletin. 2026;21(1):60‑67. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20262101160

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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Abstract:

The objective of the study was to evaluate achievement of target doses of essential medications (ACE inhibitors/ARBs/ARNIs, beta-blockers, MRA and SGLT2) and patient adherence to therapy. We analyzed medication prescriptions depending on CHF phenotype and left ventricular ejection fraction (LVEF), as well as dynamics of clinical and laboratory parameters (LVEF and NT-proBNP). There was low rate of achievement of target doses for beta-blockers and ACE inhibitors/ARBs/ARNIs (<20% of patients), while MRAs were prescribed at optimal doses in more than 90% of cases. Only 50.6% of patients demonstrated high adherence to therapy. Repeated assessment of LVEF and NTproBNP was performed in only a subset of patients. However, patients on optimal medical therapy showed improvements of LVEF and decrease of NTproBNP. Therefore, it is necessary to increase physician awareness, improve compliance with clinical guidelines and intensify follow-up to improve treatment adherence and prognosis in patients with CHF.

Keywords:

chronic heart failure

CHF

CHF registry

CHF treatment

registry

seamless care

Authors:

Airapetyan A.A.

Chazov National Medical Research Center of Cardiology, Moscow, Russia

ORCID: 0000-0002-7064-5328

Mezhonov E.M.

Tyumen State Medical University, Tyumen, Russia;
Regional Clinical Hospital No. 1, Tyumen, Russia

ORCID: 0000-0002-6086-4578

Reitblat O.M.

Regional Clinical Hospital No. 1, Tyumen, Russia;
Tyumen Region Health Department, Tyumen, Russia

ORCID: 0000-0002-9407-5497

Lazareva N.V.

Chazov National Medical Research Center of Cardiology, Moscow, Russia

ORCID: 0000-0002-3253-0669

Sorokin E.V.

Chazov National Medical Research Center of Cardiology, Moscow, Russia

ORCID: 0000-0001-8395-937X

Prints Yu.Sh.

Regional Clinical Hospital No. 1, Tyumen, Russia;
Ministry of Health of the Russian Federation, Moscow, Russia

ORCID: 0000-0001-8331-6307

Zhirov I.V.

Chazov National Medical Research Center of Cardiology, Moscow, Russia;
Russian Medical Academy of Continuous Professional Education, Moscow, Russia

ORCID: 0000-0002-4066-2661

Tereshchenko S.N.

Chazov National Medical Research Center of Cardiology, Moscow, Russia

ORCID: 0000-0001-9234-6129

Boytsov S.A.

Chazov National Medical Research Center of Cardiology, Moscow, Russia

ORCID: 0000-0001-6998-8406

Received:

28.07.2025

Accepted:

18.09.2025

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References:

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