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Pankrashina Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Yavelov I.S.

National Medical Research Center for Therapy and Preventive Medicine

Kaperiz K.A.

National Medical Research Center for Therapy and Preventive Medicine

Rastatueva A.O.

National Medical Research Center for Therapy and Preventive Medicine

Relationship between chronic heart and venous insufficiency: possible mechanisms and clinical research findings

Authors:

Pankrashina Yu.A., Yavelov I.S., Kaperiz K.A., Rastatueva A.O.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2026;28(2): 103‑108

DOI: 10.17116/profmed202629021103

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Table of contents

RELATIONSHIP BETWEEN CHRONIC HEART AND VENOUS INSUFFICIENCY: POSSIBLE MECHANISMS AND CLINICAL RESEARCH FINDINGS
RELATIONSHIP BETWEEN CHRONIC HEART AND VENOUS INSUFFICIENCY: POSSIBLE MECHANISMS AND CLINICAL RESEARCH FINDINGS

To cite this article:

Pankrashina YuA, Yavelov IS, Kaperiz KA, Rastatueva AO. Relationship between chronic heart and venous insufficiency: possible mechanisms and clinical research findings. Russian Journal of Preventive Medicine. 2026;28(2):103‑108. (In Russ.)
https://doi.org/10.17116/profmed202629021103

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Chronic venous insufficiency (CVI) of the lower extremities is common and was once considered a localized disease. Recent evidence shows systemic effects of CVI, especially its link to the onset and progression of chronic heart failure (CHF).

OBJECTIVE

To characterize the possible relationships between chronic venous insufficiency of the lower extremities and chronic heart failure, to analyze the pathophysiological mechanisms of their interaction, as well as the role of chronic venous insufficiency of the lower extremities as a predictor of the development and progression of chronic heart failure.

MATERIALS AND METHODS

The article reviews publications indicating a possible relationship between CVI and CHF. Sources were identified by searching the PubMed, eLibrary, and Google Scholar databases. Articles available in full-text, published from 2006 to 2025, were selected.

RESULTS

CVI has been shown to be associated with an increased risk of CHF, mortality, and adverse cardiovascular outcomes. Venous congestion and right heart dysfunction induce endothelial dysfunction, inflammation, and myocardial remodeling, forming a vicious circle.

CONCLUSION

The accumulated data indicate that chronic venous insufficiency of the lower extremities and chronic heart failure are interrelated, and their combination worsens the prognosis. Further research is needed to clarify the mechanisms underlying the cause-and-effect relationship and to develop a comprehensive therapy.

Keywords:

chronic venous insufficiency
chronic heart failure
venous congestion
decompensation
varicose veins

Authors:

Pankrashina Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Yavelov I.S.

National Medical Research Center for Therapy and Preventive Medicine

Kaperiz K.A.

National Medical Research Center for Therapy and Preventive Medicine

Rastatueva A.O.

National Medical Research Center for Therapy and Preventive Medicine

Received:

09.10.2025

Accepted:

11.11.2025

Close metadata

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