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Mironov N.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Karanadze N.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Krasilnikova E.S.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Lugovtsov A.E.

Physics Faculty of the Lomonosov Moscow State University, Moscow, Russia

Maksimov M.K.

Physics Faculty of the Lomonosov Moscow State University, Moscow, Russia

Zakharchuk S.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Priezzhev A.V.

Physics Faculty of the Lomonosov Moscow State University, Moscow, Russia

Orlova Ya.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Association of red blood cell distribution width with aggregation parameters in patients with chronic heart failure

Authors:

Mironov N.A., Karanadze N.A., Krasilnikova E.S., Lugovtsov A.E., Maksimov M.K., Zakharchuk S.A., Priezzhev A.V., Orlova Ya.A.

More about the authors

Journal: Russian Cardiology Bulletin. 2026;21(1): 68‑74

DOI: 10.17116/Cardiobulletin20262101168

Read: 454 times

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Table of contents

ASSOCIATION OF RED BLOOD CELL DISTRIBUTION WIDTH WITH AGGREGATION PARAMETERS IN PATIENTS WITH CHRONIC HEART FAILURE
ASSOCIATION OF RED BLOOD CELL DISTRIBUTION WIDTH WITH AGGREGATION PARAMETERS IN PATIENTS WITH CHRONIC HEART FAILURE

To cite this article:

Mironov NA, Karanadze NA, Krasilnikova ES, et al. Association of red blood cell distribution width with aggregation parameters in patients with chronic heart failure. Russian Cardiology Bulletin. 2026;21(1):68‑74. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20262101168

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To investigate the relationship between RDW and spontaneous erythrocyte aggregation in patients with chronic heart failure (CHF).

MATERIAL AND METHODS

The study enrolled 48 patients with CHF with reduced and moderately reduced left ventricular ejection fraction (LVEF) and 11 volunteers without CVD. All participants underwent routine clinical blood count. Erythrocyte aggregation parameters were measured by laser aggregometry using the RheoScan AnD-300 aggregometer. Blood viscosity was controlled by a Lamy Rheology RM100 CP1000 rotational viscometer.

RESULTS

CHF patients demonstrated significantly higher RDW-CV (14.4 [13.2; 16.2] % vs. 12.8 [12.2; 13.4] %, p=0.005) and RDW-SD (48.2 [45.2; 53.7] fL vs. 42.7 [41.6; 44.0] fL, p=0.001) than controls. In the CHF subgroup with RDW-CV ≥ 16%, spontaneous aggregation parameters were elevated: M-index 10.8±2.0 vs. 8.9±2.0 (p=0.007), A1 0.040±0.005 vs. 0.034±0.007 (p<0.001), and combined A1+A2 0.062±0.009 vs. 0.052±0.012 (p=0.004). Regression analysis demonstrated significant associations between RDW-CV and aggregation metrics: M-index (β=0.49; 95% CI [0.08; 0.90], p=0.021), y0 (β=34.31; 95% CI [8.30; 60.32], p=0.012), and A1 (β=154.43; 95% CI [28.06; 280.79], p=0.019).

CONCLUSION

Elevated RDW is associated with enhanced spontaneous erythrocyte aggregation in CHF patients, suggesting a possible causal role of anisocytosis in microcirculatory impairment. RDW may serve not only as a marker of cardiovascular pathology but also as a potential therapeutic and prognostic target to improve hemorheology in CHF and other CVD.

Keywords:

red blood cell distribution width
erythrocyte aggregation
chronic heart failure

Authors:

Mironov N.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Karanadze N.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Krasilnikova E.S.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Lugovtsov A.E.

Physics Faculty of the Lomonosov Moscow State University, Moscow, Russia

Maksimov M.K.

Physics Faculty of the Lomonosov Moscow State University, Moscow, Russia

Zakharchuk S.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Priezzhev A.V.

Physics Faculty of the Lomonosov Moscow State University, Moscow, Russia

Orlova Ya.A.

Medical Research Educational Institute of the Lomonosov Moscow State University, Moscow, Russia

Received:

24.08.2025

Accepted:

19.09.2025

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