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Zairova A.R.
Chazov National Medical Research Centre of Cardiology
Rogoza A.N.
National Medical Research Center of Cardiology
Oshchepkova E.V.
National Medical Research Center of Cardiology
Kutsenko V.A.
National Medical Research Center for Therapy and Preventive Medicine
Shalnova S.A.
National Medical Research Center for Therapy and Preventive Medicine
Trubachev I.A.
Tomsk Research Institute of Cardiology
Serebryakova V.N.
Cardiology Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences
Kaveshnikov V.S.
Tomsk Research Institute of Cardiology
Prognostic markers of early vascular aging according to volumetric sphygmography in adult urban population sample. (Based on the ESSE-RF study in Tomsk)
Journal: Russian Cardiology Bulletin. 2023;18(1): 55‑64
Read: 1626 times
To cite this article:
Zairova AR, Rogoza AN, Oshchepkova EV, et al. . Prognostic markers of early vascular aging according to volumetric sphygmography in adult urban population sample. (Based on the ESSE-RF study in Tomsk). Russian Cardiology Bulletin.
2023;18(1):55‑64. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20231801155
To form the markers of early vascular aging (EVA) based on parameter of arterial stiffness (CAVI, cardio-ankle vascular index) and to study their prognostic significance for cardiovascular events in adult population of Tomsk (ESSE-RF epidemiological study).
There were 342 people (543 men and 799 women) aged 25—64 (47.3±11.6) years. All ones underwent volumetric sphygmography for analysis of arterial stiffness (CAVI). Cardiovascular events were registered in prospective follow-up (mean 4.7 years). We analyzed several EVA markers regarding primary combined (mortality from cardiovascular diseases, non-fatal myocardial infarction or stroke) and secondary combined endpoints (all cardiovascular events).
We assessed the markers EVA-56, EVA-65, EVA-84 and EVA-97.5 formed as excess of the 56th, 65th, 84th and 97.5th percentiles of CAVI distribution in different age ranges. Moreover, we analyzed EVA-VS as excess of «vascular age» (VaSera-1500) over chronological age. Multivariate Cox model involving gender, age, obesity, smoking, arterial hypertension, diabetes mellitus and dyslipidemia confirmed prognostic value of EVA-65 (RR 3.38 95% CI 1.16—9.79, p=0.025), EVA-97.5 (RR 4.87, 95% CI 1.07—22.14, p=0.041) and EVA-VS (RR 5.16, 95% CI 1.4—19.03, p=0.014) for primary combined endpoint and EVA-97.5 (RR 3.59, 95% CI 1.1—11.69, p=0.034) for secondary combined endpoint.
EVA may be recommended in population studies to identify high-risk people among patients over 55 years old without previous myocardial infarction or stroke. The same is true for construction of new multivariate prognostic models. EVA is formed according to volumetric sphygmography data as excess of the 97.5th percentile of age-adjusted CAVI. EVA as excess of the 65th percentile of CAVI or excess of «vascular age» over chronological age is more promising for assessing individual prognosis of cardiovascular events in clinical practice and identifying high-risk persons.
Keywords:
Authors:
Zairova A.R.
Chazov National Medical Research Centre of Cardiology
Rogoza A.N.
National Medical Research Center of Cardiology
Oshchepkova E.V.
National Medical Research Center of Cardiology
Kutsenko V.A.
National Medical Research Center for Therapy and Preventive Medicine
Shalnova S.A.
National Medical Research Center for Therapy and Preventive Medicine
Trubachev I.A.
Tomsk Research Institute of Cardiology
Serebryakova V.N.
Cardiology Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences
Kaveshnikov V.S.
Tomsk Research Institute of Cardiology
Received:
29.10.2022
Accepted:
21.11.2022
List of references:
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