Prognostic markers of early vascular aging according to volumetric sphygmography in adult urban population sample. (Based on the ESSE-RF study in Tomsk)

Zairova A.R.

Chazov National Medical Research Centre of Cardiology

Rogoza A.N.

National Medical Research Center of Cardiology

Oshchepkova E.V.

National Medical Research Center of Cardiology

Yarovaya E.B.

Lomonosov Moscow State University

ORCID: 0000-0002-6615-4315

Kutsenko V.A.

National Medical Research Center for Therapy and Preventive Medicine

ORCID: 0000-0001-9844-3122

Shalnova S.A.

National Medical Research Center for Therapy and Preventive Medicine

SPIN RSCI: 9189-8637
Scopus AuthorID: 6603427718
ORCID: 0000-0003-2087-6483

Trubachev I.A.

Tomsk Research Institute of Cardiology

SPIN RSCI: 8605-2140
Scopus AuthorID: 6506949883
ResearcherID: F-5446-2014
ORCID: 0000-0003-1063-7382

Serebryakova V.N.

Cardiology Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Kaveshnikov V.S.

Tomsk Research Institute of Cardiology

Boytsov S.A.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-6998-8406

Prognostic markers of early vascular aging according to volumetric sphygmography in adult urban population sample. (Based on the ESSE-RF study in Tomsk)

Authors:

Zairova A.R., Rogoza A.N., Oshchepkova E.V., Yarovaya E.B., Kutsenko V.A., Shalnova S.A., Trubachev I.A., Serebryakova V.N., Kaveshnikov V.S., Boytsov S.A.

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Journal: Russian Cardiology Bulletin. 2023;18(1): 55‑64

DOI: 10.17116/Cardiobulletin20231801155

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To cite this article:

Zairova AR, Rogoza AN, Oshchepkova EV, et al. . Prognostic markers of early vascular aging according to volumetric sphygmography in adult urban population sample. (Based on the ESSE-RF study in Tomsk). Russian Cardiology Bulletin. 2023;18(1):55‑64. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20231801155

Подписка 2025-2 (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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OBJECTIVE

To form the markers of early vascular aging (EVA) based on parameter of arterial stiffness (CAVI, cardio-ankle vascular index) and to study their prognostic significance for cardiovascular events in adult population of Tomsk (ESSE-RF epidemiological study).

MATERIAL AND METHODS

There were 342 people (543 men and 799 women) aged 25—64 (47.3±11.6) years. All ones underwent volumetric sphygmography for analysis of arterial stiffness (CAVI). Cardiovascular events were registered in prospective follow-up (mean 4.7 years). We analyzed several EVA markers regarding primary combined (mortality from cardiovascular diseases, non-fatal myocardial infarction or stroke) and secondary combined endpoints (all cardiovascular events).

RESULTS

We assessed the markers EVA-56, EVA-65, EVA-84 and EVA-97.5 formed as excess of the 56^th, 65^th, 84^th and 97.5^th percentiles of CAVI distribution in different age ranges. Moreover, we analyzed EVA-VS as excess of «vascular age» (VaSera-1500) over chronological age. Multivariate Cox model involving gender, age, obesity, smoking, arterial hypertension, diabetes mellitus and dyslipidemia confirmed prognostic value of EVA-65 (RR 3.38 95% CI 1.16—9.79, p=0.025), EVA-97.5 (RR 4.87, 95% CI 1.07—22.14, p=0.041) and EVA-VS (RR 5.16, 95% CI 1.4—19.03, p=0.014) for primary combined endpoint and EVA-97.5 (RR 3.59, 95% CI 1.1—11.69, p=0.034) for secondary combined endpoint.

CONCLUSION

EVA may be recommended in population studies to identify high-risk people among patients over 55 years old without previous myocardial infarction or stroke. The same is true for construction of new multivariate prognostic models. EVA is formed according to volumetric sphygmography data as excess of the 97.5th percentile of age-adjusted CAVI. EVA as excess of the 65^th percentile of CAVI or excess of «vascular age» over chronological age is more promising for assessing individual prognosis of cardiovascular events in clinical practice and identifying high-risk persons.

Keywords:

ESSE-RF

volumetric sphygmography

arterial stiffness

early vascular aging

prognosis

cardiovascular events

Authors:

Zairova A.R.

Chazov National Medical Research Centre of Cardiology

Rogoza A.N.

National Medical Research Center of Cardiology

Oshchepkova E.V.

National Medical Research Center of Cardiology

Yarovaya E.B.

Lomonosov Moscow State University

ORCID: 0000-0002-6615-4315

Kutsenko V.A.

National Medical Research Center for Therapy and Preventive Medicine

ORCID: 0000-0001-9844-3122

Shalnova S.A.

National Medical Research Center for Therapy and Preventive Medicine

SPIN RSCI: 9189-8637
Scopus AuthorID: 6603427718
ORCID: 0000-0003-2087-6483

Trubachev I.A.

Tomsk Research Institute of Cardiology

SPIN RSCI: 8605-2140
Scopus AuthorID: 6506949883
ResearcherID: F-5446-2014
ORCID: 0000-0003-1063-7382

Serebryakova V.N.

Cardiology Research Institute of the Tomsk National Research Medical Center of the Russian Academy of Sciences

Kaveshnikov V.S.

Tomsk Research Institute of Cardiology

Boytsov S.A.

Chazov National Medical Research Center of Cardiology

ORCID: 0000-0001-6998-8406

Received:

29.10.2022

Accepted:

21.11.2022

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