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Shalnova S.A.

National Medical Research Center for Therapy and Preventive Medicine

Yarovaya E.B.

National Medical Research Center for Therapy and Preventive Medicine;
Lomonosov Moscow State University

Filichkina E.M.

National Medical Research Center for Therapy and Preventive Medicine;
Lomonosov Moscow State University

Muromtseva G.A.

National Medical Research Center for Therapy and Preventive Medicine

Kapustina A.V.

National Medical Research Center for Therapy and Preventive Medicine

Balanova Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Imaeva A.E.

National Medical Research Center for Therapy and Preventive Medicine

Evstifeeva S.E.

National Medical Research Center for Therapy and Preventive Medicine

Maksimov S.A.

National Medical Research Center for Therapy and Preventive Medicine

Risk of ischemic heart diseases adverse outcomes in the working age men and women taking part in the prospective epidemiological surveillance

Authors:

Shalnova S.A., Yarovaya E.B., Filichkina E.M., Muromtseva G.A., Kapustina A.V., Balanova Yu.A., Imaeva A.E., Evstifeeva S.E., Maksimov S.A.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(6): 60‑66

DOI: 10.17116/profmed20252806160

Read: 403 times

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Table of contents

RISK OF ISCHEMIC HEART DISEASES ADVERSE OUTCOMES IN THE WORKING AGE MEN AND WOMEN TAKING PART IN THE PROSPECTIVE EPIDEMIOLOGICAL SURVEILLANCE
RISK OF ISCHEMIC HEART DISEASES ADVERSE OUTCOMES IN THE WORKING AGE MEN AND WOMEN TAKING PART IN THE PROSPECTIVE EPIDEMIOLOGICAL SURVEILLANCE

To cite this article:

Shalnova SA, Yarovaya EB, Filichkina EM, et al. . Risk of ischemic heart diseases adverse outcomes in the working age men and women taking part in the prospective epidemiological surveillance. Russian Journal of Preventive Medicine. 2025;28(6):60‑66. (In Russ.)
https://doi.org/10.17116/profmed20252806160

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Reclassification of ischemic heart disease epidemiological criteria. Russian Journal of Preventive Medi­cine. 2024;(12):61-68
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Abstract:

The course of most cardiovascular diseases in males and females has specific features.

OBJECTIVE

To study the gender-specific features of the modified classification of ischemic heart diseases (IHDs) when assessing the risk of an adverse cardiovascular outcome.

MATERIALS AND METHODS

A survey to detect angina pectoris (AP) and myocardial infarction (MI) and a unified electrocardiogram analysis using the Minnesota code were conducted on 13.745 participants in the ESSAY-RF study (40.7% males) aged 25-64 from representative samples of the population of nine regions of the Russian Federation. Over 9.5 years of prospective follow-up, a composite endpoint (CEP; cardiovascular death and/or non-fatal MI or stroke) was identified in 611 (4.4%) subjects, of which 364 (6.5%) were males and 247 (3.0%) were females. Prognostic value was determined by Kaplan—Meier methods and proportional Cox risk-adjusted in sex groups for age and region, in the population for age, region, and sex (model 1), and additionally for smoking and cardiometabolic parameters (continuous and discrete, models 2 and 3).

RESULTS

The hazard ratio (HR) of CEP in the new IHDs classification was higher than in the old one. In the definite IHD group, the HR was 3.57 versus 2.6 in males and 3.58 versus 1.98 in females (model 1). In models 2 and 3 (2/3), relative to model 1, the HR was lower at 3.19/3.16 compared to 3.57 in males and 2.52/2.69 compared to 3.58 in females. According to studies, it is impossible to differentiate the survival of individuals in any of the groups according to the criteria of the old classification of IHD. The new classification showed a significantly lower survival rate in men (especially with definite IHD nosology) than in women.

CONCLUSION

The modified classification of ischemic heart diseases is adequate to assess the HR of the composite endpoint in males and females. Compared to women, men of working age have a higher HR of the composite endpoint and poorer survival.

Keywords:

ischemic heart diseases
gender-specific features
hazard ratio
composite endpoint
definite IHD nosology
possible IHD
cardiovascular events

Authors:

Shalnova S.A.

National Medical Research Center for Therapy and Preventive Medicine

Yarovaya E.B.

National Medical Research Center for Therapy and Preventive Medicine;
Lomonosov Moscow State University

Filichkina E.M.

National Medical Research Center for Therapy and Preventive Medicine;
Lomonosov Moscow State University

Muromtseva G.A.

National Medical Research Center for Therapy and Preventive Medicine

Kapustina A.V.

National Medical Research Center for Therapy and Preventive Medicine

Balanova Yu.A.

National Medical Research Center for Therapy and Preventive Medicine

Imaeva A.E.

National Medical Research Center for Therapy and Preventive Medicine

Evstifeeva S.E.

National Medical Research Center for Therapy and Preventive Medicine

Maksimov S.A.

National Medical Research Center for Therapy and Preventive Medicine

Received:

21.02.2025

Accepted:

28.03.2025

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References:

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