A Topical Agent Based on Recombinant Human Epidermal Growth Factor and Silver Sulfadiazine Accelerates the Healing of Venous (Chronic) Ulcers: A Prospective Comparative Non-Randomized Study ESKIZ

Yakushkin S.N.; Galchenko M.I.; Dzhambaeva A.A.; Ilyukhin E.A.; Kurginyan Kh.M.; Maytesyan Sh.A.; Pasov A.S.; Sharifov Sh.L.

doi:https://doi.org/10.17116/flebo202519041284

Yakushkin S.N.

Elena Malysheva Medical Center

ORCID: 0009-0003-4652-2103

Galchenko M.I.

Ozon Pharmaceuticals

ORCID: 0000-0002-5476-6058

Dzhambaeva A.A.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0009-0005-8050-3509

Ilyukhin E.A.

Medalp Surgical Clinic

SPIN RSCI: 6611-1950
Scopus AuthorID: 55681461600
ResearcherID: S-2324-2018
ORCID: 0000-0002-8288-8239

Kurginyan Kh.M.

Federal Network of Laser Surgery Clinics “No varicose veins”

SPIN RSCI: 9609-8010
Scopus AuthorID: 57211348245
ORCID: 0000-0002-5990-8561

Maytesyan Sh.A.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0000-0001-6034-5359

Pasov A.S.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0009-0009-2754-8416

Sharifov Sh.L.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0009-0009-8245-0307

A Topical Agent Based on Recombinant Human Epidermal Growth Factor and Silver Sulfadiazine Accelerates the Healing of Venous (Chronic) Ulcers: A Prospective Comparative Non-Randomized Study ESKIZ

Authors:

Yakushkin S.N., Galchenko M.I., Dzhambaeva A.A., Ilyukhin E.A., Kurginyan Kh.M., Maytesyan Sh.A., Pasov A.S., Sharifov Sh.L.

More about the authors

Journal: Journal of Venous Disorders. 2025;19(4): 284‑294

DOI: 10.17116/flebo202519041284

Read: 408 times

Contact the author

Table of contents

To cite this article:

Yakushkin SN, Galchenko MI, Dzhambaeva AA, et al. . A Topical Agent Based on Recombinant Human Epidermal Growth Factor and Silver Sulfadiazine Accelerates the Healing of Venous (Chronic) Ulcers: A Prospective Comparative Non-Randomized Study ESKIZ. Journal of Venous Disorders. 2025;19(4):284‑294. (In Russ.)
https://doi.org/10.17116/flebo202519041284

Подписка 2026 Флебология (Journal of Venous Disorders)

Использование инфографики авторами научных работ

THE OBJECTIVE OF THE STUDY

Was to evaluate the effectiveness of a topical agent based on recombinant human epidermal growth factor and silver sulfadiazine in accelerating the healing of venous stasis (chronic) ulcers.

MATERIALS AND METHODS

A prospective, comparative, non-randomized study was conducted, including 180 patients with venous stasis ulcers. Wound coverings and compression therapy were used in all patients. In the test group, the studied agent was applied to the ulcer under the wound covering; in the control group, topical ointments/gels were not used.

RESULTS

The studied agent provided the best outcome for ulcer reduction. The relative decrease in area (% of baseline) after 1 month of follow-up was (Me [Q1; Q3]) –43.3% [–59.2; –29.9] and –36.2% [–52.0; –21.0] (p=0.021) in the study and control groups, respectively. The absolute change in area (cm²) after 1 month was –2.1 [–4.4; –1.1] and –1.0 [–2.1; –0.2] (p≤0.001), and after 2 months, –4.2 [–6.8; –2.9] and –2.2 [–4.3; –0.8] (p≤0.001), respectively. The proportion of patients with a fully healed ulcer, re-weighted by the initial ulcer area, was 2.3% and 0.4% (p=0.025) at 1 month, and 39.4% and 27.6% (p≤0.001) at 2 months, respectively. For ulcers with an initial area of more than 5 cm², the relative decrease in area (% of the initial area) at 1 month was –49.1% [–60.0; –40.0] and –30.5% [–40.0; –20.0] (p≤0.001), respectively, and the absolute decrease (cm²) was –4.3 [–6.4; –2.7] and –2.8 [–3.4; –1.6] (p≤0.001), respectively. In patients with varicose veins, no differences were found between the groups in the relative decrease in the area of ulcers after 1 month (p=0.256), but differences were found in the absolute change in area (cm²): –2.1 [–4.7; –1.1] and –0.7 [–1.3; –0.2] (p≤0.001), respectively.

CONCLUSIONS

A topical agent based on recombinant human epidermal growth factor and silver sulfadiazine accelerates the healing of venous stasis (chronic) ulcers.

Keywords:

venous stasis ulcer

topical agents

chronic venous insufficiency

trophic disorders

chronic venous diseases

varicose veins

post-thrombotic disease

Authors:

Yakushkin S.N.

Elena Malysheva Medical Center

ORCID: 0009-0003-4652-2103

Galchenko M.I.

Ozon Pharmaceuticals

ORCID: 0000-0002-5476-6058

Dzhambaeva A.A.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0009-0005-8050-3509

Ilyukhin E.A.

Medalp Surgical Clinic

SPIN RSCI: 6611-1950
Scopus AuthorID: 55681461600
ResearcherID: S-2324-2018
ORCID: 0000-0002-8288-8239

Kurginyan Kh.M.

Federal Network of Laser Surgery Clinics “No varicose veins”

SPIN RSCI: 9609-8010
Scopus AuthorID: 57211348245
ORCID: 0000-0002-5990-8561

Maytesyan Sh.A.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0000-0001-6034-5359

Pasov A.S.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0009-0009-2754-8416

Sharifov Sh.L.

Network of laser surgery clinics “Varicoza Net”

ORCID: 0009-0009-8245-0307

Received:

11.10.2025

Accepted:

26.10.2025

Close metadata

References:

Norman G, Westby MJ, Rithalia AD, Stubbs N, Soares MO, Dumville JC. Dressings and topical agents for treating venous leg ulcers. Cochrane Database Syst Rev. 2018;6(6):CD012583. https://doi.org/10.1002/14651858.CD012583.pub2
Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J. 2013;10(2):159-166. https://doi.org/10.1111/j.1742-481X.2012.00957.x
Meaume S, Ourabah Z, Romanelli M, Manopulo R, De Vathaire F, Salomon D, Saurat JH. Efficacy and tolerance of a hydrocolloid dressing containing hyaluronic acid for the treatment of leg ulcers of venous or mixed origin. Curr Med Res Opin. 2008;24(10):2729-2739. https://doi.org/10.1185/03007990802367041
de la Brassinne M, Thirion L, Horvat LIL. A novel method of comparing the healing properties of two hydrogels in chronic leg ulcers. J Eur Acad Dermatol Venereol JEADV. 2006;20(2):131-135. https://doi.org/10.1111/j.1468-3083.2006.01342.x
He Q, Wu G, Yu B, Zhang T, Wang W, Gu Q. A prospective study on wound-healing hydrogel in treating chronic venous ulcer of lower extremities. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi Zhongguo Xiufu Chongjian Waike Zazhi Chin J Reparative Reconstr Surg. 2008;22(3):311-313. (In Chinese).
Associacija flebologov Rossii. Varikoznoe rasshirenie ven nizhnih konechnostej. Klinicheskie rekomendacii. Rubrikator klinicheskih rekomendacij MZ RF. nojabr‘ 2024 g. Accessed September 14, 2025. (In Russ.). https://cr.minzdrav.gov.ru/preview-cr/680_2
Reestr klinicheskih issledovanij Associacii flebologov Rossii (RKI AFR). Sajt Reestra klinicheskih issledovanij AFR. Accessed September 14, 2025. (In Russ.). https://clinicaltrials.phlebounion.ru
Ilyukhin EA, Bulatov VL, Galchenko MI. Reliability and Accuracy of Measuring the Surface Area of Phantom Skin Lesions with Lesionmeter Mobile Application. Journal of Venous Disorders. 2020;14(4):266-274. (In Russ., In Engl.). https://doi.org/10.17116/flebo202014041266
Karch JD. bmtest: A Jamovi Module for Brunner–Munzel’s Test—A Robust Alternative to Wilcoxon–Mann–Whitney’s Test. Psych. 2023;5(2):386-395. https://doi.org/10.3390/psych5020026
De Maeseneer MG, Kakkos SK, Aherne T, Baekgaard N, Black S, Blomgren L, Giannoukas A, Gohel M, de Graaf R, Hamel-Desnos C, Jawien A, Jaworucka-Kaczorowska A, Lattimer CR, Mosti G, Noppeney T, van Rijn MJ, Stansby G, Esvs Guidelines Committee null, Kolh P, Bastos Goncalves F, Chakfé N, Coscas R, de Borst GJ, Dias NV, Hinchliffe RJ, Koncar IB, Lindholt JS, Trimarchi S, Tulamo R, Twine CP, Vermassen F, Wanhainen A, Document Reviewers null, Björck M, Labropoulos N, Lurie F, Mansilha A, Nyamekye IK, Ramirez Ortega M, Ulloa JH, Urbanek T, van Rij AM, Vuylsteke ME. Editor’s Choice — European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. Eur J Vasc Endovasc Surg. 2022;63(2):184-267. https://doi.org/10.1016/j.ejvs.2021.12.024
Gloviczki P. Handbook of Venous and Lymphatic Disorders: Guidelines of the American Venous Forum. 5th ed. CRC Press; 2024.
Kamaev AA, Bulatov VL, Vakhratyan PE, Volkov AM, Volkov AS, Gavrilov EK, Golovina VI, Efremova OI, Ivanov OO, Ilyukhin EA, Katorkin SE, Konchugova TV, Kravtsov PF, Maksimov SV, Mzhavanadze ND, Pikhanova ZhM, Pryadko SI, Smirnov AA, Sushkov SA, Chabbarov RG, Shimanko AI, Yakushkin SN, Apkhanova TV, Derkachev SN, Zolotukhin IA, Kalinin RE, Kirienko AI, Kulchitskaya DB, Pelevin AV, Petrikov AS, Rachin AP, Seliverstov EI, Stoyko YuM, Suchkov IA. Clinical Guidelines. Varicose Veins. Journal of Venous Disorders. 2022;16(1):41-108. (In Russ.). https://doi.org/10.17116/flebo20221601141
Zolotukhin IA, Suchkov IA, Ilyukhin EA, Seliverstov EI, Kamaev AA, Petrikov AS, Shimanko AI, Stoyko YuM. Clinical Decisions in the Absence of Evidence: Expert’s Panel Recommendations for the Management of Chronic Venous Disease and Superficial Thrombophlebitis. Journal of Venous Disorders. 2025;19(2):126-140. https://doi.org/10.17116/flebo202519021126
Westby MJ, Norman G, Dumville JC, Stubbs N, Cullum N. Protease-modulating matrix treatments for healing venous leg ulcers. Cochrane Wounds Group, ed. Cochrane Database Syst Rev. 2016;2017(4). https://doi.org/10.1002/14651858.CD011918.pub2