The objective of the present study was to evaluate the effectiveness of the methods for attention distraction during the outpatient surgical treatment of varicose vein disease. Material and methods. This randomized clinical study involved 357 patients including 308 (86.3%) women and 49 (13.7%) men with mean age of 41.4±15.2 years who underwent endovenous thermal ablation of the great saphenous vein under tumescent anesthesia in combination with miniphlebectomy in outpatient setting. All the patients were divided into five groups treated with the use of the following technologies for distraction of attention: the control group (n=66), listening to music (n=72), watching a movie (n=75, anti-stress ball (n=70), and direct interaction (n=74). The results were estimated based on the Aberdeen Questionnaire (AVVQ), McGill Questionnaire, Spielberger’s State-Trait Anxiety Inventory (S-STAI) as modified by Yu.L. Hanin, and visual-analog scale (VAS). Results. The study has demonstrated the significant direct relationship between the initial and intraoperative levels of anxiety evaluated with the use of VAS (p<0.001). The type of the surgical intervention had no appreciable influence on the anxiety level (p=0.43) whereas the use of the attention distraction technologies produced a pronounced effect depending on the method employed (p<0.0001). The most effective tools for the reduction of the anxiety level on VAS were watching a movie (p<0.001), interaction (p<0.001), and an anti-stress ball (p=0.009). Interaction significantly reduced the anxiety level on S-STAI scale in comparison with the control group (p=0.003). Type of the surgical intervention had no effect on the severity of the intraoperative pain assessed by VAS (p=0.68). Attention distraction turned out to be an essential factor influencing pain intensity (p<0.01). Interaction appears to be the most effective for the alleviation of intraoperative pain when compared with the controls (p=0.022) the same refers to the use of the anti-stress ball (p=0.002). The results obtained by McGill questionnaire give evidence that the sensorial and effective pain levels were unrelated to the type of the surgical intervention (p=0.89 and p=0.57 respectively); nor did they depend on the technology for distraction of attention applied (p=0.27 and p=0.94 respectively). The multifactorial analysis failed to reveal the influence of either age or sex of the patients on the level of intraoperative anxiety whereas the level of anxiety in preoperative period proved to be a reliable predictor of pain intensity based on VAS (p<0.001) and SF-MPQ (p<0.001). Conclusion. Application of the technologies for the distraction of attention helps to reduce both anxiety and pain during the outpatient invasive interventions for varicose veins.