The objective of this article is to analyse the prescriptions issued by the physicians participating in the project "Venous thromboembolic complication safety zone" and the conformance of the recommended treatments to the modern requirements. A total of 53,596 patients were included in the study of whom 78% underwent surgical intervention at general surgical, traumatic-orthopedic, and surgical clinics. The early activization was the most frequent modality recommended (80.2% of the cases). The use of various compression devices and pharmacoprophylaxis were prescribed to 71.4% and 68.7% of the patients respectively. The prescriptions were found to be in full conformity with the national clinical recommendations in 70% and 46% of the patients belonging to the high-risk and moderate-risk groups respectively. As many as 8% and 15% of the patients in these groups, respectively, were prescribed the treatment with anticoagulants without compression, in agreement with the internationally accepted practice. 93% of the low-risk patients were treated based on the high-efficacy preventive scheme. Part of the patients received no therapy whatever (2% in the high-risk group, 5% and 7% in the moderate-risk and low-risk groups respectively). The analysis of prescriptions of anticoagulation therapy has demonstrated that enoxaparin was most frequently recommended to the patients of the high-risk and low-risk groups (58% and 41% respectively). Both the doses of anticoagulants and the mode of their application conformed with the respective national recommendations (in 86% and 71% of the patients referred to the groups with the high and moderate risk of development of venous thromboembolic complications, respectively). The duration of preventive treatment varied between 7 days (36% of the cases), 7-10 days (46% of the cases), and more than 10 days (in 18% of the cases). The majority of the patients were recommended the adequate preventive measures by their attending doctors. As a result, only 17 (0.03% ) of the 53,596 patients died during their stay in the hospital.