Laparoscopic surgery for solid pseudopapillary tumors of the pancreas in children

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OBJECTIVE

To present the experience of using laparoscopic surgery for solid pseudopapillary pancreatic tumors in children.

MATERIAL AND METHODS

In the Morozov Children’s City Clinical Hospital from 2012 to 2021 16 patients underwent laparoscopic surgery for a solid pseudopapillary pancreatic tumor. In 12 patients the tumor was located in the tail of the pancreas, in 4 patients the tumor was located in the body of the pancreas. 12 laparoscopic distal pancreatectomy and 4 central pancreatectomy were performed.

RESULTS

The duration of the operation varied from 80 to 200 minutes (mean value, 95 minutes). In all cases, intraoperative blood loss did not exceed 100 ml and did not require blood transfusion in any case. One patient (6.25%) who underwent laparoscopic central pancreatectomy during surgery was converted to laparotomy. The total period of postoperative hospital stay was 10—14 days (on average, 12 days). The follow-up was followed in all patients in terms of 3 months to 5 years. In all cases, a routine cyclic examination (ultrasound screening, CT with intravenous contrast enhancement) was performed, in which no recurrence of the disease was detected in any case.

CONCLUSION

Laparoscopic operations in children with solid pseudopapillary tumor in the tail and body of the pancreas are feasible provided that the clinic has sufficient experience in minimally invasive and pancreatic surgery. In the hands of an experienced surgeon, laparoscopic distal pancreatectomy may be the preferred treatment for pseudopapillary solid tumors in children.

Keywords:

solid pseudopapillary tumor of the pancreas

children

laparoscopy

distal pancreatectomy

central pancreatectomy

Authors:

Ryabov A.B.

Hertsen Moscow Oncology Research Institute

Poddubniy I.V.

Morozovskaya Children’s City Clinical Hospital;
Evdokimov Moscow State University of Medicine and Dentistry

Trunov V.O.

Morozovskaya Children’s City Clinical Hospital;
Pirogov Russian National Research Medical University

Kozlov M.Yu.

Morozov Children’s City Clinical Hospital

Khizhnikov A.V.

Morozovskaya Children’s City Clinical Hospital

Imanalieva A.A.

Russian Peoples’ Friendship University

Manzhos P.I.

Russian Peoples’ Friendship University

Contribution of Authors:

Concept and design of the study — A.B. Ryabov, I.V. Poddubnyi, V.O. Trunov, P.I. Manzhos

Data collection and processing —V.O. Trunov, A.V. Khizhnikov, M.Yu. Kozlov

Statistical processing of the data — V.O. Trunov, A.V. Khizhnikov

Text writing — V.O. Trunov, A.A. Imanalieva

Editing — A.B. Ryabov, I.V. Poddubnyi, P.I. Manzhos

Received:

20.12.2021

Accepted:

15.02.2022

List of references:

Brillantino C, Rossi E, Pirisi P, Gaglione G, Errico ME, Minelli R, Menna BF, Zeccolini R, Zeccolini M. Pseudopapillary solid tumour of the pancreas in paediatric age: description of a case report and review of the literature [published online ahead of print, 2021 Apr 24]. J Ultrasound. 2021;10.1007/s40477-021-00587-7. https://doi.org/10.1007/s40477-021-00587-7
Vassos N, Agaimy A, Klein P, Hohenberger W, Croner RS. Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity. Int J Clin Exp Pathol. 2013;6(6):1051-1059. Published 2013 May 15.
Bender AM, Thompson ED, Hackam DJ, Cameron JL, Rhee DS. Solid pseudopapillary neoplasm of the pancreas in a young pediatric patient: A case report and systematic review of the literature. Pancreas. 2018;47(10):1364-1368. https://doi.org/10.1097/MPA.0000000000001183
Hu S, Lin X, Song Q, Chen K. Solid pseudopapillary tumour of the pancreas in children: clinical and computed tomography manifestation. Radio Med. 2012;117(7):1242-1249. https://doi.org/10.1007/s11547-012-0854-2
Butte JM, Brennan MF, Gönen M, Tang LH, D’Angelica MI, Fong Y, Dematteo RP, Jarnagin WR, Allen PJ. Solid pseudopapillary tumors of the pancreas. Clinical features, surgical outcomes, and long-term survival in 45 consecutive patients from a single center. J Gastrointest Surg. 2011;15(2):350-357. https://doi.org/10.1007/s11605-010-1337-1
Crocoli A, Grimaldi C, Virgone C, De Pasquale MD, Cecchetto G, Cesaro S, Bisogno G, Cecinati V, Narciso A, Alberti D, Ferrari A, Dall’Igna P, Spada M, Inserra A. Outcome after surgery for solid pseudopapillary pancreatic tumors in children: Report from the TREP project-Italian Rare Tumors Study Group. Pediatr Blood Cancer. 2019;66(3):e27519. https://doi.org/10.1002/pbc.27519
Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005;200(06):965-972. https://doi.org/10.1016/j.jamcollsurg.2005.02.011
Sacco Casamassima MG, Gause CD, Goldstein SD, Abdullah F, Meoded A, Lukish JR, Wolfgang CL, Cameron J, Hackam DJ, Hruban RH, Colombani PM. Pancreatic surgery for tumors in children and adolescents. Pediatr Surg Int. 2016;32(8):779-788. https://doi.org/10.1007/s00383-016-3925-y
Rojas Y, Warneke CL, Dhamne CA, Tsao K, Nuchtern JG, Lally KP, Vasudevan SA, Hayes-Jordan AA, Cass DL, Herzog CE, Hicks MJ, Kim ES, Austin MT. Primary malignant pancreatic neoplasms in children and adolescents: a 20 year experience. J Pediatr Surg. 2012;47(12):2199-2204. https://doi.org/10.1016/j.jpedsurg.2012.09.005
Carricaburu E, Enezian G, Bonnard A, Berrebi D, Belarbi N, Huot O, Aigrain Y, de Lagausie P. Laparoscopic distal pancreatectomy for Frantz’s tumor in a child. Surg Endosc. 2003;17(12):2028-2031. https://doi.org/10.1007/s00464-003-4222-0
Petrosyan M, Franklin AL, Jackson HT, McGue S, Reyes CA, Kane TD. Solid pancreatic pseudopapillary tumor managed laparoscopically in adolescents: a case series and review of the literature. J Laparoendosc Adv Surg Tech A. 2014;24(6):440-444. https://doi.org/10.1089/lap.2013.0511
Cavallini A, Butturini G, Daskalaki D, Salvia R, Melotti G, Piccoli M, Bassi C, Pederzoli P. Laparoscopic pancreatectomy for solid pseudo-papillary tumors of the pancreas is a suitable technique; our experience with long-term follow-up and review of the literature [published correction appears in Ann Surg Oncol. 2011 Dec;18 Suppl 3:S324. Alvise, Cavallini [corrected to Cavallini, Alvise]; Giovanni, Butturini [corrected to Butturini, Giovanni]; Despoina, Daskalaki [corrected to Daskalaki, Despoina]; Roberto, Salvia [corrected to Salvia, Roberto]; Gianluigi, Melotti [corrected to Melotti, Gi]. Ann Surg Oncol. 2011;18(2):352-357. https://doi.org/10.1245/s10434-010-1332-5
Speer AL, Barthel ER, Patel MM, Grikscheit TC. Solid pseudopapillary tumor of the pancreas: a single-institution 20-year series of pediatric patients. J Pediatr Surg. 2012;47(6):1217-1222. https://doi.org/10.1016/j.jpedsurg.2012.03.026
Uchida H, Goto C, Kishimoto H, Kawashima H, Sato K, Yoshida M, Takazawa S. Laparoscopic spleen-preserving distal pancreatectomy for solid pseudopapillary tumor with conservation of splenic vessels in a child. J Pediatr Surg. 2010;45(7):1525-1529. https://doi.org/10.1016/j.jpedsurg.2010.03.013
Marchegiani G, Crippa S, Malleo G, Partelli S, Capelli P, Pederzoli P, Falconi M. Surgical treatment of pancreatic tumors in childhood and adolescence: uncommon neoplasms with favorable outcome. Pancreatology. 2011;11(4):383-389. https://doi.org/10.1159/000330212
Namgoong JM, Kim DY, Kim SC, Kim SC, Hwang JH, Song KB. Laparoscopic distal pancreatectomy to treat solid pseudopapillary tumors in children: transition from open to laparoscopic approaches in suitable cases. Pediatr Surg Int. 2014;30(3):259-266. https://doi.org/10.1007/s00383-014-3471-4
Mukherjee K, Morrow SE, Yang EY. Laparoscopic distal pancreatectomy in children: four cases and review of the literature. J Laparoendosc Adv Surg Tech A. 2010;20(4):373-377. https://doi.org/10.1089/lap.2009.0247
Sokolov YY, Stonogin SV, Donskoy DV, Povarnin OY, Vilesov AV. Laparoscopic pancreatic resections for solid pseudopapillary tumor in children. Eur J Pediatr Surg. 2009;19(6):399-401. https://doi.org/10.1055/s-0029-1237356
Esposito C, De Lagausie P, Escolino M, Saxena A, Holcomb GW 3rd, Settimi A, Becmeur F, van der Zee D. Laparoscopic Resection of Pancreatic Tumors in Children: Results of a Multicentric Survey. J Laparoendosc Adv Surg Tech A. 2017;27(5):533-538. https://doi.org/10.1089/lap.2016.0630
Kovler ML, Beckman RM, Goldstein SD, Stewart D. Laparoscopic Spleen-Preserving Distal Pancreatectomy for Solid Pseudopapillary Neoplasm in Adolescents. J Laparoendosc Adv Surg Tech A. 2019;29(10):1372-1377. https://doi.org/10.1089/lap.2019.0201
ElHaddad A, Gasparella P, Castellani C, Singer G, Sorantin E, Zach K, Till H. Laparoscopic Distal Pancreatectomy of a Solid Pseudopapillary Tumor (SPT) Achieves Long-Term Oncologic Safety and Multiorgan Preservation. Eur J Pediatr Surg Rep. 2019;7(1):58-62. https://doi.org/10.1055/s-0039-1693999
Lee CW, Namgoong JM, Kim DY, Kim SC, Lee SY, Cho Y, Kwon H. Perioperative Outcomes and Surgical Indications of Minimally Invasive Pancreatectomy for Solid Pseudopapillary Tumor in Pediatric Patients. Adv Pediatr Surg. 2018;24(2):76-85. https://doi.org/10.13029/aps.2018.24.2.76
Senthilnathan P, Patel N, Nalankilli VP, Palanivelu C, Parthasarthi R, Praveenraj P. Laparoscopic pylorus preserving pancreaticoduodenectomy in paediatric age for solid pseudopapillary neoplasm of head of the pancreas — case report. Pancreatology. 2014;14(6):550-552. https://doi.org/10.1016/j.pan.2014.06.005
Sokolov Yu, Stonogin S, Povarnin O, Aleinikova V, Timokhovich E, Leonidov A, Katasanova L, Lavrova T. Laparoscopic pancreas resection in children with solid pseudopapillary tumor. Pediatr Pharmacol. 2009;6(4):128-130. (In Russ.).
Rybakova DV, Kerimov PA, Kazantsev AP. Solid pseudopapillary tumor of the pancreas in children: 10 years of experience. Detskaya khirurgya (Pediatric Surgery, Russian journal) 2019; 3(1):9-13. (In Russ.). https://doi.org/10.18821/1560-9510-2019-23-1-9-13
Razumovskij AYu, Alhasov MB, Mitupov ZB, Afukov II, Demahin AA, Nagornaja JuV. Demonstration: «Laparoscopic removal of a solid pseu-dopapillary tumor of the pancreas». Rossijskij vestnik detskoj khirurgii, anesteziologii i reanimatologii. 2015;5(2):111-114. (In Russ.).
Kulevich BO, Razumovsky AYu, Kholostova VV, Mitupov ZB, Khavkin AI, Zadvernyuk AS, Chumakova GYu, Gordeeva EA. Experience in surgical treatment of diseases of the pancreas in children. Experimentalnaya i klinicheskaya gastroenterologiay. 2021;185(1):142-149. (In Russ.). https://doi.org/10.31146/1682-8658-ecg-185-1-142-149
van den Akker M, Angelini P, Taylor G, Chami R, Gerstle JT, Gupta A. Malignant pancreatic tumors in children: a single-institution series. J Pediatr Surg. 2012;47(4):681-687. https://doi.org/10.1016/j.jpedsurg.2011.11.046
Shorter NA, Glick RD, Klimstra DS, Brennan MF, Laquaglia MP. Malignant pancreatic tumors in childhood and adolescence: The Memorial Sloan-Kettering experience, 1967 to present. J Pediatr Surg. 2002;37(6):887-892. https://doi.org/10.1053/jpsu.2002.32897
Cho YJ, Namgoong JM, Kim DY, Kim SC, Kwon HH. Suggested Indications for Enucleation of Solid Pseudopapillary Neoplasms in Pediatric Patients. Front Pediatr. 2019;7:125. Published 2019 Apr 3. https://doi.org/10.3389/fped.2019.00125
Yu PF, Hu ZH, Wang XB, Guo JM, Cheng XD, Zhang YL, Xu Q. Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol. 2010;16(10):1209-1214. https://doi.org/10.3748/wjg.v16.i10.1209
Senthilnathan P, Dhaker KC, Kaje V, Naidu SB, Sarvani M, Sabnis SC, Srivatsan Gurumurthy S, Nalakilli VP, Anand Vijay N, Rajapandian S, Praveen Raj P, Parthasarathi R, Palanivelu C. Laparoscopic management of solid pseudo papillary neoplasm of pancreas in tertiary care center from south India. Pancreatology. 2017;17(6):927-930. https://doi.org/10.1016/j.pan.2017.09.003
Lee SY, Allen PJ, Sadot E, D’Angelica MI, DeMatteo RP, Fong Y, Jarnagin WR, Kingham TP. Distal pancreatectomy: a single institution’s experience in open, laparoscopic, and robotic approaches. J Am Coll Surg. 2015;220(1):18-27. https://doi.org/10.1016/j.jamcollsurg.2014.10.004
Iacobone M, Citton M, Nitti D. Laparoscopic distal pancreatectomy: up-to-date and literature review. World J Gastroenterol. 2012;18(38):5329-5337. https://doi.org/10.3748/wjg.v18.i38.5329
Yoon YS, Lee KH, Han HS, Cho JY, Jang JY, Kim SW, Lee WJ, Kang CM, Park SJ, Han SS, Ahn YJ, Yu HC, Choi IS. Effects of laparoscopic versus open surgery on splenic vessel patency after spleen and splenic vessel-preserving distal pancreatectomy: a retrospective multicenter study. Surg Endosc. 2015;29(3):583-588. https://doi.org/10.1007/s00464-014-3701-9
Chen S, Zhan Q, Chen JZ, Jin JB, Deng XX, Chen H, Shen BY, Peng CH, Li HW. Robotic approach improves spleen-preserving rate and shortens postoperative hospital stay of laparoscopic distal pancreatectomy: a matched cohort study. Surg Endosc. 2015;29(12):3507-3518. https://doi.org/10.1007/s00464-015-4101-5
Daouadi M, Zureikat AH, Zenati MS, Choudry H, Tsung A, Bartlett DL, Hughes SJ, Lee KK, Moser AJ, Zeh HJ. Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique. Ann Surg. 2013;257(1):128-132. https://doi.org/10.1097/SLA.0b013e31825fff08
Shoup M, Brennan MF, McWhite K, Leung DH, Klimstra D, Conlon KC. The value of splenic preservation with distal pancreatectomy. Arch Surg. 2002;137(2):164-168. https://doi.org/10.1001/archsurg.137.2.164
Postlewait LM, Kooby DA. Laparoscopic distal pancreatectomy for adenocarcinoma: safe and reasonable? J Gastrointest Oncol. 2015;6(4):406-417. https://doi.org/10.3978/j.issn.2078-6891.2015.034
Baca I, Bokan I. Laparoskopische Pankreassegmentresektion bei Pankreaszystadenom [Laparoscopic segmental pancreas resection and pancreatic cystadenoma]. Chirurg. 2003;74(10):961-965. https://doi.org/10.1007/s00104-003-0690-y
Zhang RC, Zhang B, Mou YP, Xu XW, Zhou YC, Huang CJ, Zhou JY, Jin WW, Lu C. Comparison of clinical outcomes and quality of life between laparoscopic and open central pancreatectomy with pancreaticojejunostomy. Surg Endosc. 2017;31(11):4756-4763. https://doi.org/10.1007/s00464-017-5552-7
Liu R, Liu Q, Zhao ZM, Tan XL, Gao YX, Zhao GD. Robotic versus laparoscopic distal pancreatectomy: A propensity score-matched study. J Surg Oncol. 2017;116(4):461-469. https://doi.org/10.1002/jso.24676
Lalli R, Merritt N, Schlachta CM, Bütter A. Robotic-assisted, spleen-preserving distal pancreatectomy for a solid pseudopapillary tumour in a pediatric patient: a case report and review of the literature. J Robot Surg. 2019;13(2):325-329. https://doi.org/10.1007/s11701-018-0835-0

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