Endometriosis and genital malformations in children and adolescents. What do they have in common?

Close metadata

Recommended articles:

The role of polymorphism rs148982377 of the ZNF789 gene in the formation of infertility in patients with endometriosis. Russian Journal of Human Reproduction. 2024;(1):64-71

The quality of dental care in children with permanent teeth trauma according to analysis of medical records in an emergency unit of a municipal dental clinic. Stomatology. 2024;(1):41-47

Application of narrow-band optical radiation with a wavelength of 650 nm in complex treatment of children with developmental speech delay. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(1):5-12

The use of transcranial micropolarization in the acute period of severe traumatic brain injury in children. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(1):13-21

Historical aspects of the formation and development of children’s health resort medicine in the Samara region. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(1):62-69

Comparative analysis of subjective and objective methods of obstructive sleep apnea syndrome diagnosis in children. Russian Rhinology. 2024;(1):11-15

Features of genetic mutations in children with high myopia combined with peripheral retinal degenerations. Russian Annals of Ophthalmology. 2024;(1):19-24

Prevalence and risk factors of non-suicidal self-injury behavior. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(2):13-19

Prolonged spinal and sacral neurostimulation in children with pelvic organ dysfunction: preliminary analysis. Burdenko's Journal of Neurosurgery. 2024;(2):31-38

First experience of using CAD EYE technology. Artificial intelligence-assisted colonoscopy in children. (A series of clinical cases). Russian Journal of Evidence-Based Gastroenterology. 2024;(1):94-100

Endometriosis is a gynaecological disease characterised by the presence of tissue with morphological and functional properties similar to endometrium outside the uterine cavity. This pathology affects about 10% of women of reproductive age worldwide and currently has no established etiology. The true prevalence of EM in adolescence remains unknown, varies depending on the inclusion criteria for each study and the diagnostic methods used and, unlike in premenopausal women, can range from 19% to 100% of cases, according to different authors. Developmental anomalies of the female genital organs account for 3—7% in the structure of gynaecological diseases in children and adolescents. The possibility of combining congenital pathology with the presence of EM should cause special vigilance of gynaecologists when examining adolescent girls.

Keywords:

genital malformations

endometriosis

children

adolescents

Authors:

Adamyan L.V.

Russian University of Medicine;
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov

SPIN RSCI: 9836-2713
Scopus AuthorID: 7006372422
ResearcherID: Q-1722-2018
ORCID: 0000-0002-3253-4512

Alyasova A.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

ORCID: 0000-0003-2621-0359

Stepanian A.A.

Academia of Women’s Health and Endoscopic Surgery

Received:

12.04.2024

Accepted:

08.05.2024

List of references:

Koninckx PR, Ussia A, Gordts S, Keckstein J, Saridogan E, Malzoni M, Stepanian A, Setubal A, Adamyan L, Wattiez A. The 10 «Cardinal Sins» in the Clinical Diagnosis and Treatment of Endometriosis: A Bayesian Approach. Journal of Clinical Medicine. 2023; 12(13):4547. https://doi.org/10.3390/jcm12134547
Liakopoulou M- K, Tsarna E, Eleftheriades A, Arapaki A, Toutoudaki K, Christopoulos P. Medical and Behavioral Aspects of Adolescent Endometriosis: A Review of the Literature. Children (Basel). 2022;9(3):384. https://doi.org/10.3390/children9030384
Adamyan LV, Farhat KN, Makiyan ZN. An integrated approach to the diagnosis, surgical correction and rehabilitation of patients with a combination of uterine and vaginal malformations with endometriosis. Problemy’ reprodukcii. 2016;22(3):84-90. (In Russ.). https://doi.org/10.17116/repro201622384-90
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertility and Sterility. 2019;111(2):327-340. https://doi.org/10.1016/j.fertnstert.2018.10.013
Gubbels A, Spivack L, Lindheim SR, Bhagavath B. Adolescent Endometriosis. Obstetrical and Gynecological Survey. 2020;75:483-496. https://doi.org/10.1097/OGX.0000000000000808
Hirsch M, Dhillon-Smith R, Cutner AS, Yap M, Creighton SM. The Prevalence of Endometriosis in Adolescents with Pelvic Pain: A Systematic Review. Journal of Pediatric and Adolescent Gynecology. 2020;33:623-630. https://doi.org/10.1016/j.jpag.2020.07.011
Clinical recommendations (draft). Congenital malformations of the vagina and/or uterus in children and adolescents. Reproduktivnoe zdorov’e detej i podrostkov. 2021;17(3):31-56. (In Russ.). https://doi.org/10.33029/1816-2134-2021-17-3-31-56
Bobkova MV, Puchko TK, Adamyan LV. Reproductive function in women with malformations of the uterus and vagina. Problemy’ reprodukcii. 2018;24(2):42-53. (In Russ.). https://doi.org/10.17116/repro201824242-53
Passos IMPE, Britto RL. Diagnosis and treatment of müllerian malformations. Taiwan Journal of Obstetrics and Gynecology. 2020;59(2): 183-188. https://doi.org/10.1016/j.tjog.2020.01.003
Diagnosis and management of hymenal variants. ACOG Committee Opinion No. 780. American College of Obstetricians and Gynecologists. Obstetrics and Gynecology. 2019;133:e372-376. https://doi.org/10.1097/AOG.0000000000003283
Adamyan LV, Arakelyan AS, Popryadukhin AYu. Modern approaches to the treatment of patients with uterine and vaginal aplasia by peritoneal colpopoiesis. Rossijskij vestnik akushera-ginekologa. 2021; 21(4):81-87. (In Russ.). https://doi.org/10.17116/rosakush20212104181
Kapczuk K, Zajączkowska W, Madziar K, Kędzia W. Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract. Journal of Clinical Medicine. 2023;12(5):2007. https://doi.org/10.3390/jcm12052007
ACOG Committee Opinion Number 760 Dysmenorrhea and Endometriosis in the Adolescent. Obstetrics and Gynecology. 2018; 132:249-258. https://doi.org/10.1097/AOG.000000000000
Kapczuk K., Friebe Z., Iwaniec K., Kędzia W. Obstructive müllerian anomalies in menstruating adolescent girls: A report of 22 cases. J Pediatr Adolesc Gynecol. 2018;31:252-257. https://doi.org/10.1016/j.jpag.2017.09.013
Patel V, Gomez-Lobo V. Obstructive anomalies of the gynecologic tract. Current Opinion in Obstetrics and Gynecology. 2016;28:339-344. https://doi.org/10.1097/GCO.0000000000000300
Heinonen PK. Distribution of female genital tract anomalies in two classifications. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2016;206:141-146. https://doi.org/10.1016/j.ejogrb.2016.09.009
Becker CM, Bokor A, Heikinheimo O, Horne A, Jansen F, Kiesel L, King K, Kvaskoff M, Nap A, Petersen K, Saridogan E, Tomassetti C, van Hanegem N, Vulliemoz N, Vermeulen N; ESHRE Endometriosis Guideline Group. ESHRE guideline: endometriosis. Human Reproduction Open. 2022;2022(2):hoac009. https://doi.org/10.1093/hropen/hoac009
Exacoustos C, Lazzeri L, Martire FG, Russo C, Martone S, Centini G, Piccione E, Zupi E. Ultrasound Findings of Adenomyosis in Adolescents: Type and Grade of the Disease. Journal of minimally invasive gynecology. 2022;29(2):291-299.e1 https://doi.org/10.1016/j.jmig.2021.08.023
Adamyan L, Kasyan V, Pivazyan L, Isaeva S, Avetisyan J. Laser vaporization compared with other surgical techniques in women with ovarian endometrioma: a systematic review and meta-analysis. Archives of Gynecology and Obstetrics. 2023;308(2):413-425. https://doi.org/10.1007/s00404-022-06799-4
Exacoustos C, Morosetti G, Conway F, Camilli S, Martire FG, Lazzeri L, Piccione E, Zupi E. New Sonographic Classification of Adenomyosis: Do Type and Degree of Adenomyosis Correlate to Severity of Symptoms? Journal of Minimally Invasive Gynecology. 2020; 27(6):1308-1311. https://doi.org/10.1016/j.jmig.2019.09.788
Stuparich MA, Donnellan N, Sanfilippo J. Endometriosis in the adolescent patient. Semin Reprod Med. 2017;35:102-109. https://doi.org/10.1055/s-0036-1597121
Khanna K, Sharma S, Gupta DK. Hydrometrocolpos etiology and management: past beckons the present. Pediatric Surgery International. 2018;34(3):249-261. https://doi.org/10.1007/s00383-017-4218-9
Management of Acute Obstructive Uterovaginal Anomalies: ACOG Committee Opinion, Number 779. Obstetrics and Gynecology. 2019; 133(6):e363-e371. https://doi.org/10.1097/AOG.0000000000003281
Balun J, Dominick K, Cabral MD, Taubel,D. Endometriosis in adolescents: A narrative review. Pediatric Medicine. 2019;2:33. https://doi.org/10.21037/pm.2019.0
Brosens I, Benagiano G. Clinical significance of neonatal menstruation. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2016;196:57-59. https://doi.org/10.1016/j.ejogrb.2015.11.022
Lazzeri L, Andersson K L, Angioni S, Vignali M, Zupi E, Martire FG. How to Manage Endometriosis in Adolescence: The Endometriosis Treatment Italian Club Approach. JMIG: Journal of Minimally Invasive Gynecology. 2023;30:616-626. https://doi.org/10.1016/j.jmig.2023.03.017
Gordts S, Koninckx P, Brosens I. Pathogenesis of deep endometriosis. Fertility and Sterility. 2017;108:872-885.e1. https://doi.org/https:10.1016/j.fertnstert.2017.08.03
Laganà AS, Garzon S, Götte M, Viganò P, Franchi M, Ghezzi F, Martin DC. The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights. International Journal of Molecular Sciences. 2019;20(22):5615. https://doi.org/10.3390/ijms20225615
Szukiewicz D, Stangret A, Ruiz-Ruiz C, Olivares EG, Soriţău O, Suşman S, Szewczyk G. Estrogen- and Progesterone (P4)-Mediated Epigenetic Modifications of Endometrial Stromal Cells (EnSCs) and/or Mesenchymal Stem/Stromal Cells (MSCs) in the Etiopathogenesis of Endometriosis. Stem Cell Reviews and Reports. 2021;17(4): 1174-1193. https://doi.org/10.1007/s12015-020-10115-5
Zucherato VS, Penariol LBC, Silva LECM, Padovan CC, Poli-Neto OB, Rosa-E-Silva JC, Ferriani RA, Meola J. Identification of suitable reference genes for mesenchymal stem cells from menstrual blood of women with endometriosis. Scientific Reports. 2021; 11:5422. https://doi.org/10.1038/s41598-021-84884-5
Knox B, Ong YC, Bakar MA, Grover SR. A longitudinal study of adolescent dysmenorrhoea into adulthood. European Journal of Pediatrics. 2019;178(9):1325-1332. https://doi.org/10.1007/s00431-019-03419-3
Adamyan LV, Kuznetsova MV, Pivazyan LG, Davydova YD, Trofimov DY. Genetic aspects of endometriosis and adenomyosis: a modern view of the problem. Problemy’ reprodukcii. 2023;29(4-2):14-22. (In Russ.). https://doi.org/10.17116/repro20232904214
Adamyan LV, Kuznetsova MV, Popryadukhin AYu, Pivazyan LG, Krylova EI, Trofimov DYu. Genetic aspects of malformations of female genital organs: a modern view of the problem. Problemy’ reprodukcii. 2023;29(4-2):23-28. (In Russ.). https://doi.org/10.17116/repro20232904223
Adamyan LV, Andreeva EN, Spicyn VA. Geneticheskie aspekty’ ginekologicheskix zabolevanij. M.: GE’OTAR-Media; 2008. (In Russ.).
Milewski Ł, Ścieżyńska A, Ponińska J, Soszyńska M, Barcz E, Roszkowski PI, Kamiński P, Włodarski P, Płoski R, Malejczyk J. Endometriosis Is Associated with Functional Polymorphism in the Promoter of Heme Oxygenase 1 (HMOX1) Gene. Cells. 2021;10(3):695. https://doi.org/10.3390/cells10030695
Cong L, Fu Q, Gao T. CYP17A1 rs743572 polymorphism might contribute to endometriosis susceptibility: evidences from a case-control study. Medicine (Baltimore). 2018;97(28):e11415. https://doi.org/10.1097/MD.0000000000011415
Zubrzycki A, Zubrzycki M, Janecka A, Zubrzycki M. New Horizons in the Etiopathogenesis and Non-Invasive Diagnosis of Endometriosis. Current Molecular Medicine. 2015;15:697-713. https://doi.org/10.2174/1566524015666150921105218
Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Słomka M, Smith BH, Smolarz B, Szaflik T, Szyłło K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI; DBDS Genomic Consortium; FinnGen Study; FinnGen Endometriosis Taskforce; Celmatix Research Team; 23andMe Research Team; Adachi S, Buring JE, Ridker PM, D’Hooghe T, Goulielmos GN, Hapangama DK, Hayward C, Horne AW, Low SK, Martikainen H, Chasman DI, Rogers PAW, Saunders PT, Sirota M, Spector T, Strapagiel D, Tung JY, Whiteman DC, Giudice LC, Velez-Edwards DR, Uimari O, Kraft P, Salumets A, Nyholt DR, Mägi R, Stefansson K, Becker CM, Yurttas-Beim P, Steinthorsdottir V, Nyegaard M, Missmer SA, Montgomery GW, Morris AP, Zondervan KT. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nature Genetics. 2023;55:423-436. https://doi.org/10.1038/s41588-023-01323-z
Cardoso JV, Perini JA, Machado DE, Pinto R, Medeiros R. Systematic review of genome-wide association studies on susceptibility to endometriosis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2020;255:74-82. https://doi.org/10.1038/s41588-023-01323-z
Angioni S, D’Alterio MN, Coiana A, Anni F, Gessa S, Deiana D. Genetic Characterization of Endometriosis Patients: Review of the Literature and a Prospective Cohort Study on a Mediterranean Population. Int J Mol Sci. 2020;21(5):1765. https://doi.org/10.3390/ijms21051765
Martire FG, Giorgi M, D’Abate C, Colombi I, Ginetti A, Cannoni A, Fedele F, Exacoustos C, Centini G, Zupi E, Lazzeri L. Deep Infiltrating Endometriosis in Adolescence: Early Diagnosis and Possible Prevention of Disease Progression. Journal of Clinical Medicine. 2024;13:550. https://doi.org/10.3390/jcm13020550
Akhtar MA, Saravelos SH, Li TC, Jayaprakasan K; Royal College of Obstetricians and Gynaecologists. Reproductive Implications and Management of Congenital Uterine Anomalies: Scientific Impact Paper No. 62 November 2019. BJOG. 2020;127 (5): e1-e13. https://doi.org/10.1111/1471-0528.15968
Lotz L, Dietl A, Hoffmann I, Müller A, Burghaus S, Beckmann M W, Dittrich R. Endometriosis in women undergoing ovarian tissue transplantation due to premature menopause after gonadotoxic treatment or spontaneous premature ovarian failure. Acta Obstetrica Gynecologica Scandinavica. 2022;101(7):771-778. https://doi.org/10.1111/aogs.14374
Takeuchi A, Koga K, Satake E, Makabe T, Taguchi A, Miyashita M, Takamura M, Harada M, Hirata T, Hirota Y, Yoshino O, Wada-Hiraike O, Fujii T, Osuga Y. Endometriosis triggers excessive activation of primordial follicles via PI3K-PTEN-Akt-Foxo3 pathway. The Journal of Clinical Endocrinology and Metabolism. 2019;104 (11):5547-5554. https://doi.org/10.1210/jc.2019-00281
Martire FG, Russo C, Selntigia A, Nocita E, Soreca G, Lazzeri L, Zupi E, Exacoustos C. Early noninvasive diagnosis of endometriosis: Dysmenorrhea and specific ultrasound findings are important indicators in young women. Fertility and Sterility. 2023;119(3): 455-464. https://doi.org/10.1016/j.fertnstert.2022.12.004
Pino I, Belloni GM, Barbera V, Solima E, Radice D, Angioni S, Arena S, Bergamini V, Candiani M, Maiorana A, Mattei A, Muzii L, Pagliardini L, Porpora MG, Remorgida V, Seracchioli R, Vercellini P, Zullo F, Zupi E, Vignali M; “Endometriosis Treatment Italian Club” (ETIC). Better late than never but never late is better”, especially in young women. A multicenter Italian study on diagnostic delay for symptomatic endometriosis. The European Journal of Contraception and Reproductive Health Care. 2023;28(7):10-16. https://doi.org/10.1080/13625187.2022.2128644
Adamyan LV, Sibirskaya EV, Kurbanova PF.Endometriosis in adolescent girls (literature review). Problemy’ reprodukcii. 2022;28(3): 36-42. (In Russ.). https://doi.org/10.17116/repro20222803136
Jayaprakasan K, Ojha K. Diagnosis of Congenital Uterine Abnormalities: Practical Considerations. Journal of Clinical Medicine. 2022;11(5):1251. https://doi.org/10.3390/jcm11051251
Martire FG, Lazzeri L, Conway F, Siciliano T, Pietropolli A, Piccione E, Solima E, Centini G; Zupi E, Exacoustos C. Adolescence and endometriosis: Symptoms, ultrasound signs and early diagnosis. Fertility and Sterility. 2020;114(5):1049-1057. https://doi.org/10.1016/j.fertnstert.2020.06.012
Alcázar JL, Carriles I, Cajas MB, Costa S, Fabra S, Cabrero M, Castro E, Tomaizeh A, Laza MV, Monroy A, Martinez I, Aguilar MI, Hernani E, Castellet C, Oliva A, Pascual MÁ, Guerriero S. Diagnostic Performance of Two-Dimensional Ultrasound, Two-Dimensional Sonohysterography and Three-Dimensional Ultrasound in the Diagnosis of Septate Uterus — A Systematic Review and Meta-Analysis. Diagnostics (Basel). 2023;13(4):807. https://doi.org/10.3390/diagnostics13040807
Adamyan LV, Sokolov AD, Avetisyan DS, Shapovalenko RA. Modern methods of diagnosis of adenomyosis: a systematic review. Problemy’ reprodukcii. 2023;29(3):81-90. (In Russ.). https://doi.org/10.17116/repro20232903181
Nakamura T. Clinical Aspects of Adolescent Endometriosis. Endocrines. 2021;2(3):301-310. https://doi.org/10.3390/endocrines2030028
Matalliotakis M, Goulielmos GN, Matalliotaki C, Trivli A, Matalliotakis I, Arici A. Endometriosis in Adolescent and Young Girls: Report on a Series of 55 Cases. Journal of Pediatric and Adolescent Gynecology. 2017;30(5):568-570. https://doi.org/10.1016/j.jpag.2017.05.00
Gu CL0 Zhang Z0 Fan WS, Li LA, Ye MX, Zhang Q, Zhang NN, Li Z, Meng YG. Identification of MicroRNAs as Potential Biomarkers in Ovarian Endometriosis. Reproductive Sciences. 2020;27(9): 1715-1723. https://doi.org/10.1007/s43032-020-00148-z
Zafari N, Tarafdari AM, Izadi P, Noruzinia M, Yekaninejad MS, Bahramy A, Mohebalian A. A Panel of Plasma miRNAs 199b-3p, 224-225p and Let-7d-3p as Non-Invasive Diagnostic Biomarkers for Endometriosis. Reproductive Sciences. 2021;28:991-999. https://doi.org/10.1007/s43032-020-00415-z
Monnaka VU, Hernandes C, Heller D, Podgaec S. Overview of miRNAs for the non-invasive diagnosis of endometriosis: evidence, challenges and strategies. A systematic review. Einstein (Sao Paulo). 2021;19 eRW5704. https://doi.org/10.31744/einstein_journal/2021RW5704
Rekker K, Tasa T, Saare M, Samuel K, Kadastik Ü, Karro H, Götte M, Salumets A, Peters M. Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375. International Journal of Molecular Sciences. 2018;19:3789. https://doi.org/10.3390/ijms19123789
Della Corte L, Di Filippo C, Gabrielli O, Reppuccia S, La Rosa VL, Ragusa R, Fichera M, Commodari E, Bifulco G, Giampaolo P. The Burden of Endometriosis on Women’s Lifespan: A Narrative Overview on Quality of Life and Psychosocial Wellbeing. International Journal of Environmental Research and Public Health. 2020; 17:4683. https://doi.org/10.3390/ijerph17134683
Khashchenko EP, Uvarova EV, Fatkhudinov TK, Chuprynin VD, Asaturova AV, Kulabukhova EA, Vysokikh MY, Allakhverdieva EZ, Alekseeva MN, Adamyan LV, Sukhikh GT. Endometriosis in Adolescents: Diagnostics, Clinical and Laparoscopic Features. Journal of Clinical Medicine. 2023;12(4):1678. https://doi.org/10.3390/jcm12041678

Close metadata