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Masalimova D.N.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology Petrovsky National Research Center of Surgery;
Russian Medical Academy of Continuous Professional Education

Orazov M.R.

Peoples’ Friendship University of Russia

Mikhalev S.A.

N.I. Pirogov Russian National Research Medical University

Pechnikova V.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Parfyonova O.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Ilyichev A.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Kavteladze E.V.

Center for Reproduction and Genetics “Nova Clinic”

Comparative analysis of endometrial receptivity in young women with endometrial and ovarian infertility factors

Authors:

Masalimova D.N., Mikhaleva L.M., Orazov M.R., Mikhalev S.A., Pechnikova V.V., Parfyonova O.A., Ilyichev A.V., Kavteladze E.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2026;88(1): 26‑34

DOI: 10.17116/patol20268801126

Read: 771 times

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Table of contents

COMPARATIVE ANALYSIS OF ENDOMETRIAL RECEPTIVITY IN YOUNG WOMEN WITH ENDOMETRIAL AND OVARIAN INFERTILITY FACTORS
COMPARATIVE ANALYSIS OF ENDOMETRIAL RECEPTIVITY IN YOUNG WOMEN WITH ENDOMETRIAL AND OVARIAN INFERTILITY FACTORS

To cite this article:

Masalimova DN, Mikhaleva LM, Orazov MR, et al. Comparative analysis of endometrial receptivity in young women with endometrial and ovarian infertility factors. Russian Journal of Archive of Pathology. 2026;88(1):26‑34. (In Russ.)
https://doi.org/10.17116/patol20268801126

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Infertility is a significant medical problem associated with morphological and functional changes in the endometrium and ovarian diseases that can lead to endometrial dysfunction. In this regard, it remains extremely important to study the role of endometrial and ovarian pathology in the development of infertility.

OBJECTIVE

Comparative analysis of endometrial receptivity in young women with endometrial and ovarian factors of infertility.

MATERIAL AND METHODS

We conducted a retrospective study that included 195 patients of reproductive age. Group 1 included patients with endometrial infertility factor (n=97), Group 2 included patients with ovarian infertility factor (n=38), Group 3 included women with a combination of both infertility factors (n=35). The comparison group consisted of women with infertility associated with male factor who were examined before IVF procedure (n=25). For pathomorphologic and immunohistochemical studies, the endometrium was sampled by pipelle biopsy on the 19th—22nd day of the menstrual cycle during the expected implantation window period.

RESULTS

Analysis of the results of the pathomorphologic study revealed different degrees of impaired development of pinopodes and delayed secretory transformation of the endometrium in patients of the three groups. Immunohistochemical study revealed a significant decrease in the expression level of estrogen receptors (ER) and increase in the expression of progesterone receptors (PR) in the glandular compartment in all studied groups compared to the comparison group, as well as a decrease in the expression level of ER in the stromal compartment of the endometrium in patients of groups 1 and 3.

CONCLUSION

One of the leading causes of implantation disorders in patients with endometrial and ovarian infertility factors is impaired maturation of pinopodes, delayed secretory transformation of the endometrium and displacement of the implantation window, as well as decreased expression of ER and increased expression of PR in glandular compartments in patients of the studied groups compared to the morphological control group, decreased expression of ER in the stromal compartment, in patients of groups 1 and 3.

Keywords:

endometrial receptivity
chronic endometritis
endometrioid ovarian cysts
infertility

Authors:

Masalimova D.N.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology Petrovsky National Research Center of Surgery;
Russian Medical Academy of Continuous Professional Education

Orazov M.R.

Peoples’ Friendship University of Russia

Mikhalev S.A.

N.I. Pirogov Russian National Research Medical University

Pechnikova V.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Parfyonova O.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Ilyichev A.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Kavteladze E.V.

Center for Reproduction and Genetics “Nova Clinic”

Received:

02.07.2025

Accepted:

22.10.2025

Close metadata

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