Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries

Kudimova M.A.; Mikhaleva L.M.; Krasnova I.A.; Breusenko V.G.; Esipova I.A.; Mikhalev S.A.; Gracheva N.A.

doi:https://doi.org/10.17116/patol20258704113

Kudimova M.A.

N.I. Pirogov Russian National Research Medical University

ORCID: 0000-0001-5845-7511

Mikhaleva L.M.

A.P. Avtsyn Research Institute of Human Morphology of Petrovsky National Research Center of Surgery;
G.M. Savelyeva City Clinical Hospital No. 31;
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0003-2052-914X

Krasnova I.A.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0002-6765-4127

Breusenko V.G.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0001-6999-4654

Esipova I.A.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0002-2130-5431

Mikhalev S.A.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0002-4822-0956

Gracheva N.A.

G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0001-7286-6629

Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries

Authors:

Kudimova M.A., Mikhaleva L.M., Krasnova I.A., Breusenko V.G., Esipova I.A., Mikhalev S.A., Gracheva N.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(4): 13‑23

DOI: 10.17116/patol20258704113

Read: 639 times

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To cite this article:

Kudimova MA, Mikhaleva LM, Krasnova IA, Breusenko VG, Esipova IA, Mikhalev SA, Gracheva NA. Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries. Russian Journal of Archive of Pathology. 2025;87(4):13‑23. (In Russ.)
https://doi.org/10.17116/patol20258704113

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

OBJECTIVE

To study morpho-functional changes in the endometrium of patients with uterine fibroids before and after UAE.

MATERIAL AND METHODS

116 patients were divided into 2 groups depending on the type of the leading fibroid node: 1^st — 54 patients examined with uterine fibroid (UF) types 2, 2—5, 3, 2^nd — 62 patients observed with UM types 4, 5, 6.

The comparison group — 30 healthy women. Aspiration biopsy of the endometrium was performed in the middle stage of the secretory phase before and 6—12 months after UAE. The percentage and maturity of pinopodes, the expression level of estrogen (ER), progesterone (PR) receptors in the glands, endometrial stroma, inflammatory markers (CD56+, CD138+) were determined.

RESULTS

The negative impact of UF on the morpho-functional state of the endometrium was determined. Changes were more pronounced in patients of 1^st group. Stroma indices before and after UAE corresponded to comparison group in most patients. After UAE, the number of mature pinopodes decreased in 1^st group, but not in 2^nd group. ER and PR expression levels in the glandular component decreased in all patients, being consistently higher in 1^st group. An increase in proinflammatory markers was observed only in 1^st group.

CONCLUSION

UF and UAE can disturb morpho-functional state of the endometrium. The impact assessment should be made taking into account the topographic and anatomical location of the myomatous node.

Keywords:

uterine fibroid

uterine artery embolization

endometrium

estrogen receptors

progesterone receptors

pinopodes

chronic endometritis

Authors:

Kudimova M.A.

N.I. Pirogov Russian National Research Medical University

ORCID: 0000-0001-5845-7511

Mikhaleva L.M.

ORCID: 0000-0003-2052-914X

Krasnova I.A.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0002-6765-4127

Breusenko V.G.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0001-6999-4654

Esipova I.A.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0002-2130-5431

Mikhalev S.A.

N.I. Pirogov Russian National Research Medical University;
G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0002-4822-0956

Gracheva N.A.

G.M. Savelyeva City Clinical Hospital No. 31

ORCID: 0000-0001-7286-6629

Received:

08.11.2024

Accepted:

29.04.2025

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References:

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