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Danilova N.V.

Lomonosov Moscow State University

Oleynikova N.A.

Lomonosov Moscow State University

E-cadherin: structure and functions, role in gastric cancer carcinogenesis

Authors:

Danilova N.V., Oleynikova N.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2023;85(4): 70‑77

DOI: 10.17116/patol20238504170

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To cite this article:

Danilova NV, Oleynikova NA. E-cadherin: structure and functions, role in gastric cancer carcinogenesis. Russian Journal of Archive of Pathology. 2023;85(4):70‑77. (In Russ.)
https://doi.org/10.17116/patol20238504170

Подписка 2025 (Russian Journal of Archive of Pathology)
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This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule with pivotal roles in epithelial cell behavior, tissue formation, and carcinogenesis. We summarize the structure of the E-cadherin, its role in the development of the body and in the carcinogenesis. The structure of the E-cadherin/β-catenin/αE-catenin complex and its relationship with the actin cytoskeleton are described in detail. The role of E-cadherin in the development of some infectious diseases, the function of E-cadherin as both a tumor suppressor and a promoter of tumor dissemination, its influence on signal transduction pathways in cells are highlighted. Particular attention is paid to the expression of E-cadherin in Helicobacter pylori infection and in tumor tissue in gastric cancer.

Keywords:

E-cadherin
gastric carcinoma
Helicobacter pylori
carcinogenesis
tumor progression
tumor emboli
cadherins
catenins

Authors:

Danilova N.V.

Lomonosov Moscow State University

Oleynikova N.A.

Lomonosov Moscow State University

Received:

10.01.2023

Accepted:

19.04.2023

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