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Uspenskiy Yu.P.

Saint Petersburg State Pediatric Medical University;
Pavlov First Saint Petersburg State Medical University

Baryshnikova N.V.

Saint Petersburg State Pediatric Medical University;
Pavlov First Saint Petersburg State Medical University;
Institute of Experimental Medicine

Fominykh Yu.A.

Saint Petersburg State Pediatric Medical University

Shekhtman A.V.

Saint Elizabeth City Hospital

Efficacy of alpha-glutamyl-tryptophan in the treatment of chronic atrophic gastritis: case series

Authors:

Uspenskiy Yu.P., Baryshnikova N.V., Fominykh Yu.A., Shekhtman A.V.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2024;13(4): 121‑128

DOI: 10.17116/dokgastro202413041121

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To cite this article:

Uspenskiy YuP, Baryshnikova NV, Fominykh YuA, Shekhtman AV. Efficacy of alpha-glutamyl-tryptophan in the treatment of chronic atrophic gastritis: case series. Russian Journal of Evidence-Based Gastroenterology. 2024;13(4):121‑128. (In Russ.)
https://doi.org/10.17116/dokgastro202413041121

Подписка 2025 (Russian Journal of Evidence-Based Gastroenterology)
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OBJECTIVE

To evaluate the efficacy of alpha-glutamyl-tryptophan in the treatment of chronic atrophic gastritis through clinical case examples from routine medical practice.

MATERIAL AND METHODS

Four clinical cases were selected to demonstrate the effectiveness of alpha-glutamyl-tryptophan as an anti-inflammatory agent and promoter of gastric mucosal repair in patients with chronic atrophic gastritis of varying etiologies (Helicobacter pylori-associated and autoimmune). Alpha-glutamyl-tryptophan was administered for 28 days. In cases of H. pylori-associated gastritis, it was used following standard eradication therapy, whereas in H. pylori-negative autoimmune gastritis, it was used as a first-line treatment.

RESULTS

Patients with gastric mucosal atrophy who received alpha-glutamyl-tryptophan exhibited clinical improvement (symptom resolution post-treatment), histological improvement (reduced inflammation and atrophy regression, indicated by increased gland density per mm² of gastric mucosa), and improved gastric function (elevation in pepsinogen I levels). The most challenging case involved H. pylori-associated atrophic gastritis in a patient with uncontrolled nonsteroidal anti-inflammatory drug use; nonetheless, alpha-glutamyl-tryptophan as part of a comprehensive treatment demonstrated regenerative and anti-inflammatory effects.

CONCLUSION

The presented clinical cases suggest that alpha-glutamyl-tryptophan (Regastim Gastro) contributes to the regression of atrophy, improvement of functional activity, and reduction of inflammation in the gastric mucosa. For chronic atrophic gastritis, particularly in autoimmune cases, repeated courses of treatment are recommended with intervals of at least two weeks.

Keywords:

gastritis
inflammation
atrophy
alpha-glutamyl-tryptophan
Helicobacter pylori

Authors:

Uspenskiy Yu.P.

Saint Petersburg State Pediatric Medical University;
Pavlov First Saint Petersburg State Medical University

Baryshnikova N.V.

Saint Petersburg State Pediatric Medical University;
Pavlov First Saint Petersburg State Medical University;
Institute of Experimental Medicine

Fominykh Yu.A.

Saint Petersburg State Pediatric Medical University

Shekhtman A.V.

Saint Elizabeth City Hospital

Received:

20.10.2024

Accepted:

25.10.2024

List of references:

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