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Aksenov S.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Ryabov A.B.

Hertzen Moscow Cancer Research Center

Kolobaev I.V.

Tsyb Medical Radiology Research Center

Sobolev D.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Utkina A.B.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Salimzyanov K.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kostrygin A.K.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
A. Tsyb Medical Radiological Research Center — Branch of the National Medical Radiological Research Center;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Conversion surgery for gastric cancer with limited peritoneal carcinomatosis

Authors:

Aksenov S.A., Khomyakov V.M., Ryabov A.B., Kolobaev I.V., Sobolev D.D., Utkina A.B., Salimzyanov K.I., Kostrygin A.K., Chayka A.V., Kaprin A.D.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2024;13(4): 5‑10

DOI: 10.17116/onkolog2024130415

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Table of contents

CONVERSION SURGERY FOR GASTRIC CANCER WITH LIMITED PERITONEAL CARCINOMATOSIS
CONVERSION SURGERY FOR GASTRIC CANCER WITH LIMITED PERITONEAL CARCINOMATOSIS

To cite this article:

Aksenov SA, Khomyakov VM, Ryabov AB, et al. . Conversion surgery for gastric cancer with limited peritoneal carcinomatosis. P.A. Herzen Journal of Oncology. 2024;13(4):5‑10. (In Russ.)
https://doi.org/10.17116/onkolog2024130415

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Conversion surgery for disseminated gastric cancer is attracting increasing attention as a new therapeutic strategy. A number of European and Asian studies on this topic have presented data on the advantage of performing cytoreductive surgery in a limited group of patients.

OBJECTIVE

To evaluate the safety and efficacy of conversion surgery for gastric cancer with limited peritoneal carcinomatosis.

MATERIAL AND METHODS

In the period from 2015 to 2022, 45 cytoreductive surgical interventions in patients with limited peritoneal carcinomatosis (PCI ≤7) in gastric cancer were performed in National Medical Radiology Research Center.

RESULTS

After preoperative drug treatment, 24 cases showed complete regression of carcinomatosis foci confirmed histologically and cytologically, while the remaining cases achieved partial response or stabilization. Surgical intervention was supplemented with hyperthermic intraoperative intra-abdominal chemotherapy or sessions of intra-abdominal aerosol chemotherapy. The extent of cytoreduction was considered as R0/CC-0 in 38 (84%) of 45 patients. Median overall survival was 24.1 months, with overall one- and two-year survival rates of 84.4 and 52%, respectively.

CONCLUSION

Analysis of the results of conversion surgery for gastric cancer with limited peritoneal carcinomatosis has demonstrated the safety and efficacy of this approach with careful selection of patients. Further recruitment and analysis of the accumulated experience will make it possible to clarify the criteria for selecting patients for conversion surgery, as well as the optimal regimens of perioperative drug treatment.

Keywords:

gastric cancer
carcinomatosis
conversion surgery
intra-abdominal aerosolized chemotherapy
cytoreductive surgeries

Authors:

Aksenov S.A.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Ryabov A.B.

Hertzen Moscow Cancer Research Center

Kolobaev I.V.

Tsyb Medical Radiology Research Center

Sobolev D.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Utkina A.B.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Salimzyanov K.I.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center of the Ministry of Health of Russia

Kostrygin A.K.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Kaprin A.D.

P.A. Herzen Moscow Oncology Research Institute — Branch of the National Medical Radiology Research Center;
A. Tsyb Medical Radiological Research Center — Branch of the National Medical Radiological Research Center;
Peoples’ Friendship University of Russia named after Patrice Lumumba

Received:

22.01.2024

Accepted:

24.03.2024

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References:

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